Cobalt nanomaterials as a delivery system in combating infectious diseases and cancer
Abstract
Infectious diseases and cancer possessing the most serious public health hazards throughout the world require the developments of more effective strategies to control them. The conventional therapies such as chemotherapy and radiotherapy have been restricted with their side effects and low efficiency such as insolubility, toxicity, non-specificity, drug resistance and other biological barriers urging for new technologies with more suitable therapeutic efficacies. Cobalt, the essential ultra-trace component, is involved in the metabolism of various organisms owing to its pivotal role in cobalamin (vitamin B12). Cobalt nanomaterials (CoNMs) such as cobalt nanoparticles (CoNPs) and cobalt oxide nanoparticles (CoO, Co2O3, Co3O4 NPs) have attracted attention not only for their nano-sizes, high surface area to volume ratios, intrinsic spinel crystal structures, photochemical, catalytic and bio-imaging features, ferromagnetic, antimicrobial and anticancer activities but also for their low synthesized costs, hypo-toxicity, photothermal conversion and high drug loading capabilities against anticancer and anti-infection treatments. Their surface-modifications with ligands/coatings and cargos may enhance their therapeutic efficiencies as nano-medicinal delivery system against diseases. This review demonstrates mainly the synthesis of CoNMs and their surface functionalization, characterizations, mechanisms of action, biomedical applications, toxicity, and elimination to consider them as future suitable nano-medicinal delivery system in combating infectious diseases and cancer.
Keywords: Infectious diseases and cancer; Cobalt nanomaterials; Delivery system; Therapeutic efficacies
Keywords:
Infectious diseases and cancer, Cobalt nanomaterials, Delivery system, Therapeutic efficaciesDOI
https://doi.org/10.22270/jddt.v15i12.7467References
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