Efficacy and Safety of 5-Hydroxytryptamine-3 Receptor Antagonists (5-HT3 RAs) for The Prevention of Chemotherapy-Induced Nausea and Vomiting in Cancer Patients: A Review
Abstract
Objective: This review provides an update review of the efficacy and safety of 5-hydroxytryptamine-3 receptor antagonists in the prevention of chemotherapy-induced nausea and vomiting (CINV) in cancer patients.
Methods: The information was collected from electronic scientific search engines from PubMed, Science Direct, Scopus, and Google Scholar. The publication dates covered were from 2010 to 2020. The primary endpoint was the percentage of patients who achieved a complete response (CR), complete control (CC), no nausea, no emesis, or no rescue medication.The secondary endpoint was the percentage of patients who experience constipation related to 5-HT RA constipation, headache, diarrhea, or dizziness, as well as changes in heart rhythm.
Results: Fourteen articles were identified. Palonosetron has the same effectiveness as granisetron as but more effective than ondansetron in the delayed phase and overall. Adverse effects that often occur due to the use of palonosetron, granisetron, and ondansetron are constipation and headache. Some of the articles also mentioned that palonosetron does not cause changes in heart rhythm but granisetron and ondansetron do cause changes in the electrocardiogram (ECG) at certain doses.
Conclusion: Palonosetron has the same effectiveness as granisetron, and more effective than ondansetron in delayed, and overall phases. The use of palonosetron, granisetron, and ondansetron cause constipation and headaches at all doses, palonosetron does not cause ECG abnormalities whereas granisetron and ondansetron cause ECG changes.
Keywords: palonosetron, ondansetron, granisetron, 5-HT3 RAs, cancer, nausea, vomiting, CINV.
Keywords:
palonosetron, ondansetron, granisetron, 5-HT3 RAs, cancer, nausea, vomiting, CINV
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References
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12. Matsumaru A, Tsutsumi Y, Ito S. Comparative investigation of the anti-emetic effects of granisetron and palonosetron during the treatment of acute myeloid leukemia. Mol Clin Oncol. 2017; 7(4):629–32.
13. Uchida M, Nakamura T, Hata K, Watanabe H, Mori Y, Kato K, et al. Antiemetic efficacy and safety of granisetron or palonosetron alone and in combination with a corticosteroid for ABVD therapy-induced nausea and vomiting. J Pharm Heal Care Sci. 2018; 4(1):1–7.
14. Parathoduvil AA, Sisupalan A, Rema PL. Comparison of antiemetic effectiveness of palonosetron versus ondansetron in patients on cancer chemotherapy: A prospective observational study in south Indians. J Clin Diagnostic Res. 2017; 11(5):FC10–4.
15. Mattiuzzi GN, Cortes JE, Blamble DA, Bekele BN, Xiao L, Cabanillas M, et al. Daily palonosetron is superior to ondansetron in the prevention of delayed chemotherapy-induced nausea and vomiting in patients with acute myelogenous leukemia. Cancer. 2010; 116(24):5659–66.
16. Hatoum HT, Lin SJ, Buchner D, Cox D. Comparative clinical effectiveness of various 5-HT3 RA antiemetic regimens on chemotherapy-induced nausea and vomiting associated with hospital and emergency department visits in real world practice. Support Care Cancer. 2012; 20(5):941–9.
17. Grunberg SM, Koeller JM. Palonosetron: A unique 5-HT3 -receptor antagonist for the prevention of chemotherapy-induced emesis. Expert Opin Pharmacother. 2003; 4(12):2297–303.
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20. Gonullu G, Demircan S, Demirag MK, Erdem D, Yucel I. Electrocardiographic findings of palonosetron in cancer patients. Support Care Cancer. 2012; 20(7):1435–9.
21. Yavas C, Dogan U, Yavas G, Araz M, Yavas Ata O. Acute effect of palonosetron on electrocardiographic parameters in cancer patients: A prospective study. Support Care Cancer. 2012; 20(10):2343–7.
22. Cakir FB, Yapar O, Canpolat C, Akalin F, Berrak SG. Cardiac effects of granisetron in a prospective crossover randomized dose comparison trial. Support Care Cancer. 2012; 20(10):2451–7.
23. Mason JW, Moon TE, O’Boyle E, Dietz A. Arandomized, placebo-controlled, four-period crossover, definitive QT study of the effects of APF530 exposure, high-dose intravenous granisetron, and moxifloxacin on QTc prolongation. Cancer Manag Res. 2014; 6(1):181–90.
24. Zuo P, Haberer LJ, Fang L, Hunt TL, Ridgway D, Russo MW. Integration of modeling and simulation to support changes to ondansetron dosing following a randomized, double-blind, placebo-, and active-controlled thorough QT study. J Clin Pharmacol. 2014; 54(11):1221–9.
25. Drach J, Huang H, Samoilova O, Belch A, Farber C, Bosly A, et al. Efficacy and safety of frontline rituximab, cyclophosphamide, doxorubicin and prednisone plus bortezomib (VR-CAP) or vincristine (R-CHOP) in a subset of newly diagnosed mantle cell lymphoma patients medically eligible for transplantation in the randomized. Leuk Lymphoma. 2018; 59(4):896–903.
26. Shajib MS, Khan WI. The role of serotonin and its receptors in activation of immune responses and inflammation. Acta Physiol. 2015; 213(3):561–74.
27. Maemondo M, Masuda N, Sekine I, Kubota K, Segawa Y, Shibuya M, et al. A phase II study of palonosetron combined with dexamethasone to prevent nausea and vomiting induced by highly emetogenic chemotherapy. Ann Oncol. 2009; 20(11):1860–6.
2. Chatterjee D, Roy S, Hazra A, Dasgupta P, Ganguly S, Das AK. Variation of adverse drug reaction profile of platinum-based chemotherapy with body mass index in patients with solid tumors: An observational study. Indian J Pharmacol. 2014; 46(2):222–4.
3. Bloechl-Daum B, Deuson RR, Mavros P, Hansen M, Herrstedt J. Delayed nausea and vomiting continue to reduce patients’ quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment. J Clin Oncol. 2006; 24(27):4472–8.
4. Razvi Y, Chan S, McFarlane T, McKenzie E, Zaki P, DeAngelis C, et al. ASCO, NCCN, MASCC/ESMO: a comparison of antiemetic guidelines for the treatment of chemotherapy-induced nausea and vomiting in adult patients. Support Care Cancer. 2019; 27(1):87–95.
5. Berryman LY. Pharmacotherapy Handbook. 2nd Edition. Vol. 34, The Annals of Pharmacotherapy. 2000; 1490–1490 p.
6. Feinberg B, Gilmore J, Haislip S, Jackson J, Jain G, Balu S, et al. Impact of initiating antiemetic prophylaxis with palonosetron versus ondansetron on risk of uncontrolled chemotherapy-induced nausea and vomiting in patients with lung cancer receiving multi-day chemotherapy. Support Care Cancer. 2012; 20(3):615–23.
7. Ekins S, Xu JJ. Drug Efficacy, Safety, and Biologics Discovery. Canada: Wiley; 2009. 4 p.
8. Saito B, Nakashima H, Abe M, Murai S, Baba Y, Arai N, et al. Efficacy of palonosetron to prevent delayed nausea and vomiting in non-Hodgkin’s lymphoma patients undergoing repeated cycles of the CHOP regimen. Support Care Cancer. 2018; 26(1):269–74.
9. Boccia R, Grunberg S, Franco-Gonzales E, Rubenstein E, Voisin D. Efficacy of oral palonosetron compared to intravenous palonosetron for the prevention of chemotherapy-induced nausea and vomiting associated with moderately emetogenic chemotherapy: A phase 3 trial. Support Care Cancer. 2013; 21(5):1453–60.
10. Patel MP, Woodring S, Randazzo DM, Friedman HS, Desjardins A, Healy P, et al. Response to the letter to the “Randomized open-label phase II trial of 5-day aprepitant plus ondansetron compared to ondansetron alone in the prevention of chemotherapy-induced nausea-vomiting (CINV) in glioma patients receiving adjuvant temozolomide.” Support Care Cancer. 2020; 28(12):5591–2.
11. Tian W, Wang Z, Zhou J, Zhang S, Wang J, Chen Q, et al. Randomized, double-blind, crossover study of palonosetron compared with granisetron for the prevention of chemotherapy-induced nausea and vomiting in a Chinese population. Med Oncol. 2011; 28(1):71–8.
12. Matsumaru A, Tsutsumi Y, Ito S. Comparative investigation of the anti-emetic effects of granisetron and palonosetron during the treatment of acute myeloid leukemia. Mol Clin Oncol. 2017; 7(4):629–32.
13. Uchida M, Nakamura T, Hata K, Watanabe H, Mori Y, Kato K, et al. Antiemetic efficacy and safety of granisetron or palonosetron alone and in combination with a corticosteroid for ABVD therapy-induced nausea and vomiting. J Pharm Heal Care Sci. 2018; 4(1):1–7.
14. Parathoduvil AA, Sisupalan A, Rema PL. Comparison of antiemetic effectiveness of palonosetron versus ondansetron in patients on cancer chemotherapy: A prospective observational study in south Indians. J Clin Diagnostic Res. 2017; 11(5):FC10–4.
15. Mattiuzzi GN, Cortes JE, Blamble DA, Bekele BN, Xiao L, Cabanillas M, et al. Daily palonosetron is superior to ondansetron in the prevention of delayed chemotherapy-induced nausea and vomiting in patients with acute myelogenous leukemia. Cancer. 2010; 116(24):5659–66.
16. Hatoum HT, Lin SJ, Buchner D, Cox D. Comparative clinical effectiveness of various 5-HT3 RA antiemetic regimens on chemotherapy-induced nausea and vomiting associated with hospital and emergency department visits in real world practice. Support Care Cancer. 2012; 20(5):941–9.
17. Grunberg SM, Koeller JM. Palonosetron: A unique 5-HT3 -receptor antagonist for the prevention of chemotherapy-induced emesis. Expert Opin Pharmacother. 2003; 4(12):2297–303.
18. Smith P, Lavery A, Turkington RC. An overview of acute gastrointestinal side effects of systemic anti-cancer therapy and their management. Best Pract Res Clin Gastroenterol. 2020; 48–49:101691.
19. Clinical N, Guidelines P, Guidelines N. Antiemesis. 2019;
20. Gonullu G, Demircan S, Demirag MK, Erdem D, Yucel I. Electrocardiographic findings of palonosetron in cancer patients. Support Care Cancer. 2012; 20(7):1435–9.
21. Yavas C, Dogan U, Yavas G, Araz M, Yavas Ata O. Acute effect of palonosetron on electrocardiographic parameters in cancer patients: A prospective study. Support Care Cancer. 2012; 20(10):2343–7.
22. Cakir FB, Yapar O, Canpolat C, Akalin F, Berrak SG. Cardiac effects of granisetron in a prospective crossover randomized dose comparison trial. Support Care Cancer. 2012; 20(10):2451–7.
23. Mason JW, Moon TE, O’Boyle E, Dietz A. Arandomized, placebo-controlled, four-period crossover, definitive QT study of the effects of APF530 exposure, high-dose intravenous granisetron, and moxifloxacin on QTc prolongation. Cancer Manag Res. 2014; 6(1):181–90.
24. Zuo P, Haberer LJ, Fang L, Hunt TL, Ridgway D, Russo MW. Integration of modeling and simulation to support changes to ondansetron dosing following a randomized, double-blind, placebo-, and active-controlled thorough QT study. J Clin Pharmacol. 2014; 54(11):1221–9.
25. Drach J, Huang H, Samoilova O, Belch A, Farber C, Bosly A, et al. Efficacy and safety of frontline rituximab, cyclophosphamide, doxorubicin and prednisone plus bortezomib (VR-CAP) or vincristine (R-CHOP) in a subset of newly diagnosed mantle cell lymphoma patients medically eligible for transplantation in the randomized. Leuk Lymphoma. 2018; 59(4):896–903.
26. Shajib MS, Khan WI. The role of serotonin and its receptors in activation of immune responses and inflammation. Acta Physiol. 2015; 213(3):561–74.
27. Maemondo M, Masuda N, Sekine I, Kubota K, Segawa Y, Shibuya M, et al. A phase II study of palonosetron combined with dexamethasone to prevent nausea and vomiting induced by highly emetogenic chemotherapy. Ann Oncol. 2009; 20(11):1860–6.
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Nisaurrahmah N, Sri O, Ifora I. Efficacy and Safety of 5-Hydroxytryptamine-3 Receptor Antagonists (5-HT3 RAs) for The Prevention of Chemotherapy-Induced Nausea and Vomiting in Cancer Patients: A Review. JDDT [Internet]. 15Feb.2021 [cited 18Apr.2024];11(1-s):195-9. Available from: https://www.jddtonline.info/index.php/jddt/article/view/4554
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