Phytochemistry and Neuroprotective Potential of Bombax costatum Pellegr. & Vuillet: Bridging Traditional West African Medicine and Modern

Authors

  • Arthur Armand Arnaud Daboné Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso https://orcid.org/0009-0003-7709-8763
  • Samson Guenné Laboratory of Biochemistry, Biotechnology, Food Technology and Nutrition (LABIOTAN), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso https://orcid.org/0000-0001-5405-0861
  • Modeste Traore Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso https://orcid.org/0000-0002-0136-977X
  • Ghislain T. Kobendé Laboratory of Biochemistry, Biotechnology, Food Technology and Nutrition (LABIOTAN), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso https://orcid.org/0009-0000-6843-1833
  • Nabere Ouattara Université Daniel Ouezzin Coulibaly, BP 176 Dédougou, Burkina Faso https://orcid.org/0000-0002-1669-7506
  • Moussa Compaoré Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso https://orcid.org/0000-0002-0898-4556
  • Adama Hilou Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso
  • Martin Kiendrebéogo Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso https://orcid.org/0000-0003-2335-6184

Abstract

Background: Neuropsychiatric disorders, including epilepsy, anxiety, and depression, represent a major public health burden in West Africa, where traditional medicine remains the primary therapeutic option for many patients. Bombax costatum Pellegr. & Vuillet (Malvaceae), commonly known as the red kapok or false kapok tree, is widely used in traditional West African pharmacopoeia for these conditions.

Objective: This narrative review aimed to synthesize the ethnobotanical, phytochemical, and preclinical pharmacological data on Bombax costatum and to evaluate its neuroprotective potential.

Methods: A comprehensive literature search was conducted following PRISMA 2020 guidelines in PubMed, ScienceDirect, Google Scholar, AGORA, and Lotus Base, covering the period from 1964 to mai 2026. After removal of duplicates and application of inclusion/exclusion criteria, 86 distinct documents were selected and analyzed using thematic synthesis.

Results: Bombax costatum is a multipurpose species with more than 86 documented traditional uses, mainly for epilepsy, anxiety, depression, and hepatic disorders. Major bioactive compounds identified include epicatechin (isolated from root bark), lupeol (stem bark), along with high levels of polyphenols and flavonoids. Preclinical studies demonstrated significant anticonvulsant effects (PTZ and MES models), antidepressant-like activity (chronic mild stress model), anxiolytic properties (elevated plus maze), and antioxidant activities, primarily through GABAergic modulation, monoaminergic enhancement, and reduction of oxidative stress. The plant also exhibited hepatoprotective effects with a good safety profile (LD₅₀ > 5,000 mg/kg).

Conclusion: Bombax costatum shows promising neuroprotective potential that aligns with its traditional uses. However, current evidence is limited to preclinical studies. Future research should prioritize standardization of extracts, pharmacokinetic studies, and rigorous clinical trials to confirm efficacy and safety in humans.

Keywords: Bombax costatum, neuroprotection, epilepsy, anxiety, depression, epicatechin, lupeol, traditional African medicine, oxidative stress, GABAergic

Keywords:

Bombax costatum, , neuroprotection, , lupeol, traditional African medicine, GABAergic

DOI

https://doi.org/10.22270/jddt.v16i8.7888

Author Biographies

Arthur Armand Arnaud Daboné , Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso

Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso

Samson Guenné , Laboratory of Biochemistry, Biotechnology, Food Technology and Nutrition (LABIOTAN), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso

Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso

Modeste Traore , Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso

Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso 

Ghislain T. Kobendé , Laboratory of Biochemistry, Biotechnology, Food Technology and Nutrition (LABIOTAN), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso

Laboratory of Biochemistry, Biotechnology, Food Technology and Nutrition (LABIOTAN), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso 

Nabere Ouattara , Université Daniel Ouezzin Coulibaly, BP 176 Dédougou, Burkina Faso

Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso

 

Moussa Compaoré , Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso

Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso 

Adama Hilou, Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso

Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso 

Martin Kiendrebéogo , Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso

Laboratory of Applied Biochemistry and Chemistry (LABIOCA), Université Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso 

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Daboné AAA, Guenné S, Traoré M, Kobendé GT, Ouattara N, Compaoré M, et al. Phytochemistry and Neuroprotective Potential of Bombax costatum Pellegr. & Vuillet: Bridging Traditional West African Medicine and Modern. J. Drug Delivery Ther. [Internet]. 2026 Aug. 16 [cited 2026 Aug. 30];16(8):145-56. Available from: https://www.jddtonline.info/index.php/jddt/article/view/7888

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Vol. 16 No. 8 (2026): Volume 16, Issue 8, August 2026

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Review

Copyright (c) 2026 Arthur Armand Arnaud Daboné , Samson Guenné , Modeste Traore , Ghislain T. Kobendé , Nabere Ouattara , Moussa Compaoré , Adama Hilou, Martin Kiendrebéogo

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How to Cite

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Daboné AAA, Guenné S, Traoré M, Kobendé GT, Ouattara N, Compaoré M, et al. Phytochemistry and Neuroprotective Potential of Bombax costatum Pellegr. & Vuillet: Bridging Traditional West African Medicine and Modern. J. Drug Delivery Ther. [Internet]. 2026 Aug. 16 [cited 2026 Aug. 30];16(8):145-56. Available from: https://www.jddtonline.info/index.php/jddt/article/view/7888
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