Design and Evaluation of Gastro-Retentive Floating Tablets of Ibandronic acid
Abstract
The objective of this study is Preparation and evaluation of gastro-retentive floating tablets of Ibandronic acid by direct compression method polymers or combination. In this study, Ibandronic acid, the most commonly used biphosphonate for treating osteoporosis, was formulated as gastro retentive dosage form (GRDF) tablets to enhance its oral bioavailability. GRDDs are an approach to prolong gastric residence time, there by targeting site-specific drug release in the upper GIT for local or systemic effect. GRDF tablets of Ibandronic acid (200 mg) were characterized with the effects of Carbopol 934P, HPMC 4KM and Na-CMC at various ratios on swelling, floating, physical integrity. A prolonged dissolution profile of Ibandronic acid GRDF tablets developed in this study was observed for its thickness, friability, hardness, drug content and in-vitro drug release. Formulated Floating tablets of Ibandronic acid gave satisfactory results for various physicochemical parameters like hardness, friability, thickness, weight variation and content uniformity. Sodium bicarbonate has predominant effect on the buoyancy lag time, while HPMC K4M has predominant effect on total floating time and drug release. From the study it is evident that a promising controlled release floating tablets of Ibandronic acid can be developed to increase gastric residence time and thereby increasing its bioavailability. Both doses significantly reduced the occurrence risk of new vertebral fractures by 50–52 percent when compared to the effects of the placebo drug.
Keywords: Gastro retention, Ibandronic acid, floating tablet, Carbopol, GRDF, GRFT.
Keywords:
Gastro retention, Ibandronic acid, floating tablet, Carbopol, GRDF, GRFTDOI
https://doi.org/10.22270/jddt.v14i5.6576References
http://www.mayoclinic.org/diseases-conditions/osteoporosis/basics/risk-factors/con-20019924
Old JL, Calvert M. "Vertebral compression fractures in the elderly". American Family Physician. 2004;69(1):111-6.
Kim DH, Vaccaro AR,Osteoporotic compression fractures of the spine; current options and considerations for treatment,The spine journal:official journal of the North American Spine Society, 2006;6(5):479-87. https://doi.org/10.1016/j.spinee.2006.04.013 PMid:16934715
Osteonecrosis of the jaw (ONJ) and drug treatments for osteoporosis(PDF). nos.org.uk, The National Osteoporosis Society. Archived from the original (PDF) on 2017-06-17. Retrieved 2018-08-14.
Bauss F, Schimmer RC, Ibandronate: the first once-monthly oral bisphosphonate for treatment of postmenopausal osteoporosis, Therapeutics and Clinical Risk Management, 2006;2(1):3-18. PMC 1661644. PMID 18360577.
Pund AU, Shendge RS, Pote AK, Current approaches on gastroretentive drug delivery systems, Journal of Drug Delivery and Therapeutics. 2020;10(1):139-146 https://doi.org/10.22270/jddt.v10i1.3803
Bashir R, Majeed A, Ali T, Farooq S, Khan NA, Floating oral in-situ gel: a review, Journal of Drug Delivery and Therapeutics. 2019;9(2):442-448 https://doi.org/10.22270/jddt.v9i2.2372
Sittig HB, Pathogenesis and bisphosphonate treatment of skeletal events and bone pain in metastatic cancer: focus on ibandronate, Onkologie, 2012;35(6):380-7. doi:10.1159/000338947. PMID 22722461. S2CID 8413102. https://doi.org/10.1159/000338947 PMid:22722461
"Information for Healthcare Professionals: Bisphosphonates (marketed as Actonel, Actonel+Ca, Aredia, Boniva, Didronel, Fosamax, Fosamax+D, Reclast, Skelid, and Zometa)". U.S. Food and Drug Administration. Retrieved 27 October 2010.
"Drugs Commonly Prescribed for Osteoporosis Patients are Effective at Reducing Risk of Hip and Spine Fractures, But Panel Says May be Related to Unusual Thigh Bone Fractures When Used Long Term". Journal of Bone and Mineral Research=27 October 2010. Archived from the original on 9 April 2016. Retrieved 27 October 2010.
"Osteonecrosis of the jaw (ONJ) and drug treatments for osteoporosis" (PDF). nos.org.uk. The National Osteoporosis Society. Archived from the original (PDF) on 2017-06-17. Retrieved 2018-08-14.
Tripathi KD, Essentials of medical pharmacology, New Delhi, 2013;7, ISBN 9789350259375. OCLC 868299888. https://doi.org/10.5005/jp/books/12021
Weinstein RS, Roberson PK, Manolagas SC, (January),Giant osteoclast formation and long-term oral bisphosphonate therapy, N. Engl. J. Med., 2009;360(1): 53-62. https://doi.org/10.1056/NEJMoa0802633 PMid:19118304 PMCid:PMC2866022
Sharma D, Sharma A, Asian gastroretentive drug delivery system - a mini review Pac. J. Health Sci.,2014;1(2): 80-89. https://doi.org/10.21276/apjhs.2014.1.2.9
Handbook of Pharmaceutical Excipients, Washington DC, American Pharmaceutical Association / Pharmaceutical Society of Great Britain, 1986,41-42.
Thakur S, Ramya K, Shah DK, Raj K, Floating Drug Delivery System, Journal of Drug Delivery and Therapeutics. 2011;11(3-S):125-130 https://doi.org/10.22270/jddt.v11i3-S.4828
Kumar G, Dokala, Ch. Pallavi., Direct Compression - An Overview, International Journal of Research in Pharmaceutical and Biomedical Sciences, 2013;4(1),155-58.
Pandey A, Kumar G, Kothiyal P, Barshiliya Y, A Review on current approaches in gastro retentive drug delivery system, Asian Journal of Pharmacy and Medical Science, 2012;2(4):60-77
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