O/W Pickering emulsion stabilized by magnesium carbonate particles for drug delivery systems
Abstract
This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing particles composed of magnesium carbonate particles. Pickering oil-in-water emulsions stabilized with magnesium carbonate particles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of magnesium carbonate particles on the physicochemical properties of Pickering emulsions. The O/W Pickering emulsion was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by magnesium carbonate particles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and magnesium carbonate particles allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs.
Keywords: emulsion -Pickering-magnesium carbonate- ibuprofen-oral bioavailability
Keywords:
emulsion, Pickering, magnesium carbonate, ibuprofen, oral bioavailabilityDOI
https://doi.org/10.22270/jddt.v13i2.5925References
(1) Hamouda, T; Myc A; Donovan B; Shih AY.; Reuter JD; Baker JR, "A Novel Surfactant Nanoemulsion with a Unique Non-Irritant Topical Antimicrobial Activity against Bacteria, Enveloped Viruses and Fungi" Microbiological Research, 2001; 156(1):1–7. DOI: https://doi.org/10.1078/0944-5013-00069.
(2) Jafari SM, McClements DJ. Application of Nanoemulsions in Cosmetics. Academic Press, 2018; P. 435–475. DOI: https://doi.org/10.1016/B978-0-12-811838-2.00014-X.
(3) Dickinson E, "Hydrocolloids as Emulsifiers and Emulsion Stabilizers" Food Hydrocolloids, 2009; 23(6):1473–1482. DOI: https://doi.org/10.1016/j.foodhyd.2008.08.005.
(4) Ricaurte L, Hernández-Carrión M, Moyano-Molano M, Clavijo-Romero A, Quintanilla-Carvajal MX, "Physical, Thermal and Thermodynamical Study of High Oleic Palm Oil Nanoemulsions" Food Chemistry, 2018; 256:62–70. DOI: https://doi.org/10.1016/j.foodchem.2018.02.102.
(5) Sy P M; Djiboune A R; Diouf L A D, Soumboundou M, Ndong B, Ndiaye A, Dieng S M, Diop O, Bathily E H A L, Mbaye G, Faye M, Mbodj M, Diarra M, "Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles: A Potential System with Two Active Substances (Paracetamol and Griseofulvin)" Open Journal of Biophysics, 2018; 08:68-84. DOI: https://doi.org/10.4236/ojbiphy.2018.82006.
(6) Frelichowska J, Bolzinger M A, Valour J P, Mouaziz H, Pelletier J, Chevalier Y, "Pickering w/o Emulsions: Drug Release and Topical Delivery" International Journal of Pharmaceutics, 2009; 368 (1):7–15. DOI: https://doi.org/10.1016/j.ijpharm.2008.09.057.
(7) Frelichowska, J, Bolzinger M A, Chevalier Y, "Effects of Solid Particle Content on Properties of o/w Pickering Emulsions" Journal of Colloid and Interface Science, 2010; 351 (2):348–356. DOI: https://doi.org/10.1016/j.jcis.2010.08.019.
(8) Rondel C, "Synthèses et propriétés de mélanges de nouvelles molécules polyfonctionnelles", University of Toulouse, 2009, p. 248.
(9) Ridel L, "Emulsions de Pickering : approche théorique et applications: analyse physico-chimique des phénomènes interfaciaux: obtention d’émulsions de Pickering nanométriques de manière spontanée et d’émulsions foisonnées de Pickering", University of Lyon, 2015, p. 299. https://theses.hal.science/tel-01260157
(10) Cui Y, Threlfall M, van Duijneveldt J S, "Optimizing Organoclay Stabilized Pickering Emulsions", Journal of Colloid and Interface Science, 2011; 356 (2):665–671. DOI: https://doi.org/10.1016/j.jcis.2011.01.046.
(11) Errezma M, Mabrouk A B, Magnin A, Dufresne A, Boufi S, "Surfactant-Free Emulsion Pickering Polymerization Stabilized by Aldehyde-Functionalized Cellulose Nanocrystals", Carbohydrate Polymers, 2018; 202:621–630. DOI: https://doi.org/10.1016/j.carbpol.2018.09.018.
(12) Pickering S U, "CXCVI.—Emulsions", J. Chem. Soc., Trans., 1907; 91 (0): 2001–2021. DOI: https://doi.org/10.1039/CT9079102001.
(13) Ramsden W, "Separation of Solids in the Surface-Layers of Solutions and ‘Suspensions’ (Observations on Surface-Membranes, Bubbles, Emulsions, and Mechanical Coagulation).—Preliminary Account", Proc. R. Soc. Lond., 1904; 72(477–486):156–164. DOI: https://doi.org/10.1098/rspl.1903.0034.
(14) Tang M, Wang X, Wu F, Liu Y, Zhang S, Pang X, Li X, Qiu H, "Au Nanoparticle/Graphene Oxide Hybrids as Stabilizers for Pickering Emulsions and Au Nanoparticle/Graphene Oxide@polystyrene Microspheres", Carbon., 2014; 71:238–248. DOI: https://doi.org/10.1016/j.carbon.2014.01.034.
(15) Melle S, Lask M, Fuller G G, P"ickering Emulsions with Controllable Stability" Langmuir, 2005; 21(6):2158–2162. DOI: https://doi.org/10.1021/la047691n.
(16) Salerno A, Bolzinger M A, Rolland P, Chevalier Y, Josse D, Briançon S, "Pickering Emulsions for Skin Decontamination", Toxicology in Vitro, 2016; 34:45–54. DOI: https://doi.org/10.1016/j.tiv.2016.03.005.
(17) Sy P M, Anton N, Idoux-Gillet Y, Dieng S M, Messaddeq N, Ennahar S, Diarra M, Vandamme T F, "Pickering Nano-Emulsion as a Nanocarrier for PH-Triggered Drug Release" International Journal of Pharmaceutics, 2018; 549(1–2):299–305. DOI: https://doi.org/10.1016/j.ijpharm.2018.07.066.
(18) Sy P M, Dieng S M, Diouf L A D, Djiboune A R, Soumboundou M, Ndong B, Diop O, Bathily E H A L, Gora Mbaye, M. Diouf, Mbodj M, Diarra M, "Tramadol Encapsulation in Aqueous Phase of Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles", International Journal of Biochemistry and Biophysics 2018; 6(2):37–43. DOI: https://doi.org/10.13189/ijbb.2018.060202.
(19) Diarra M, Pourroy G, Muster D, Zingraff M, Boymond C, "Elaboration and Evaluation of an Intraoral Controlled Release Delivering System", Biomaterials, 1998; 19 (16):1523–1527. DOI: https://doi.org/10.1016/S0142-9612(98)00070-2.
(20) Dorobantu L S, Yeung A K C, Foght J M, Gray M R, "Stabilization of Oil-Water Emulsions by Hydrophobic Bacteria", Appl. Environ. Microbiol., 2004; 70 (10):6333–6336. DOI : https://doi.org/10.1128/AEM.70.10.6333-6336.2004.
(21) Rojas R, Patricia M, "Emulsification En Cuve Agitée : Rôle Du Protocole Opératoire Sur l’inversion de Phase Catastrophique", University of Toulouse, INPT, 2007, p. 158.
(22) Langevin D, Poteau S, Hénaut I, Argillier J F, "Crude Oil Emulsion Properties and Their Application to Heavy Oil Transportation", Oil & Gas Science and Technology, 2004; 59 (5):511–521. DOI: https://doi.org/10.2516/ogst:2004036.
(23) Seiller M, Puisieux F, "Les systèmes dispersés: agents de surface et Emulsions", Technique et documentation Lavoisier: Paris, 1983.
(24) Chevalier Y, Bolzinger M A, "Emulsions Stabilized with Solid Nanoparticles: Pickering Emulsions", Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2013; 439:23–34. DOI: https://doi.org/10.1016/j.colsurfa.2013.02.054.
(25) Yang F, Niu Q, Lan Q, Sun D, "Effect of Dispersion PH on the Formation and Stability of Pickering Emulsions Stabilized by Layered Double Hydroxides Particles", Journal of Colloid and Interface Science, 2007; 306 (2):285–295. DOI: https://doi.org/10.1016/j.jcis.2006.10.062.
(26) Jack D B, Handbook of Clinical Pharmacokinetic Data; Springer, 1992.
(27) Yazdanian M, Briggs K, Jankovsky C, Hawi A, "The “High Solubility” Definition of the Current FDA Guidance on Biopharmaceutical Classification System May Be Too Strict for Acidic Drugs", Pharm. Res., 2004; 21 (2):293–299.
DOI: https://doi.org/10.1023/B:PHAM.0000016242.48642.71.
(28) Miastkowska M, Sikora E, Ogonowski J, Zielina M, Łudzik A, "The Kinetic Study of Isotretinoin Release from Nanoemulsion", Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016; 510:63–68. DOI: https://doi.org/10.1016/j.colsurfa.2016.07.060.
(29) Higuchi T, "Mechanism of Sustained-Action Medication. Theoretical Analysis of Rate of Release of Solid Drugs Dispersed in Solid Matrices", Journal of Pharmaceutical Sciences, 1963; 52 (12):1145–1149. DOI: https://doi.org/10.1002/jps.2600521210.
Published
Abstract Display: 385 
PDF Downloads: 372 PDF Downloads: 65 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.