Development and Evaluation of Medicated Chewing Gum Formulations of Ondansetron
Abstract
The objective of the present study was formulation and evaluation of medicated chewing gum formulations of Ondansetron. Four medicated chewing gum formulations of Ondansetron were prepared by direct compression mould method. Formulations were characterized for physical evaluation, weight variation, stickiness, hardness/plasticity, in vitro drug release, and drug release study. All the formulations gave satisfactory results in physical evaluation, weight variation, stickiness, and hardness. The formulation of batch F4 showed best in vitro drug release which is 60.68% in 25 min and it is also more accepted by the people. In conclusion, prepared formulations can be cost-effective product and also showed better compliance and increase in bioavailability.
Keywords: Chewing gum, Ondansetron, direct compression mould method, solid oral delivery systems
Keywords:
Chewing gum, Ondansetron, direct compression mould method, solid oral delivery systemsDOI
https://doi.org/10.22270/jddt.v12i1.5207References
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