Solid Dispersion: Solubility Enhancement Technique of Poorly Water Soluble Drug
Abstract
Solid dispersion is a technique which is widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. Dispersion of one or more active ingredients (hydrophobic) is done with an inert carrier (hydrophilic) at solid-state prepared by fusion method, solvent, and melting solvent method. In this review article, we have focused on the methods of preparation, advantages, disadvantages and characterization of the solid dispersions.
Keywords: Solid dispersion; dissolution; solubility.
Keywords:
Solid dispersion, solubility, dissolutionDOI
https://doi.org/10.22270/jddt.v10i1.3925References
Abdul-Fattah AM, Bhargava HN. Preparation and in vitro evaluation of solid dispersions ofhalofantrine. Int J Pharm. 2002; 235:17-33.PubMed DOI: 10.1016/S0378-5173(01)00941-3(11)
Adel M. Aly, M.Semreen, and Mazen K. Qato. Superdisintegrants for Solid dispersion. Pharmaceutical Techlology January 2005, 68-78.
A. Martin, Solubility and Distribution Phenomena, Physical Pharmacy and Pharmaceutical Sciences, Lippincott Williams and Wilkins, 6th edition, 2011
Angus Forster, John Hempenstall, Thomas Rades. Selection of Suitable Drug and ExcipientsCandidates to Prepare Glass Solutions by Melt Extrusion for Immediate Release Oral Formu-lations. Pharmaceutical Technology Europe. 01 October 2002 (6)
Arunachalam A, Karthikeyan M, konam K, Prasad PH, Sethuraman S and Ashutoshkumar S: Solid Dispersion : A Review. Current Pharmaceutical Research 2010; (1): 82-90
A.T.M. Serajuddin; Solid Dispersion of Poorly Water-Soluble Drugs: Early Promises,A.T.M. Serajuddin; Solid Dispersion of Poorly Water-Soluble Drugs: Early Promises,
Aungst, B. J., N. H. Nguyen, N. J. Rogers, S. M. Rowe, M. A. Hussain, S. J. White and L.Shum,1977. Ampiphilic vehicles improve the oral bioavailability of a poorly soluble HIV proteaseinhibitor at high doses. Int J Pharm156:79–88 (98)
Billa, N., Yuen, K., 2000. Formulation variables affecting drug release from xanthan gum matrices at laboratory scale and pilot scale. AAPS Pharm Sci Tech. 1(4), article 30.
Cheow W, Hadinoto K. Self-assembled amorphous drug-polyelec-trolyte nanoparticle complex with enhanced dissolution rate andsaturation solubility. J Colloid Interface Sci 2012;367:518–26.
Damian F, Blaton N, Kinget R and Mooter G Van den. Physical stability of solid dispersions ofthe antiviral agent UC-781 with PEG 6000, Gelucire 44/14 and PVP K3. Int. J. Pharm. 244, 2002,87-98 (53).
Mahmoud A. Younis. Solid dispersion technology, a contemporary overview on a well established technique. Universal Journal of Pharmaceutical Research. 2017; 2(3): 15-19.
Dixit et al; A review-solid dispersion, 2014; World Journal of Pharmacy and Pharmaceutical Sciences; 3(9); 238-257.
Karanath H, Shenoy VS and Murthy RR: Industrially Feasible Alternative Approaches in the AAPS. Pharmaceutical Sciences and Technology 2006; 7: 1-9.
Kim KT, Lee JY, Lee MY, Song CK, Choi J and Kim DD: Solid Dispersions as a Drug Delivery System. Journal of Pharmaceutical Investigation 2011; 41(3): 125-142
Kramer, J., Grady, L. T. and Gajendran, J., 2005. Historical development of dissolution testing, in; Jennifer, D. and Johannes, K., Pharmaceutical dissolution testing, Taylor and Francis, 1-4.
Kumar S, Shenoy VS and Sharma PK: Solid dispersion: Pharmaceutical Technology for the improvement of various characteristics of active pharmaceutical ingredients. African journal of basic and applied sciences 2011;3(4): 116-125
Pouton, C. W., Formulation of poorly water-soluble drugs for oral administration: physico-chemical and physiological issues and the lipid formulation classification system Eur. J.Pharm. Sci., 29: 278, 2006. (14).
Akhter S, Hossen MS, Salahuddin M, Sunny MA, Sathi FA, Islam MS. In vitro dissolution study of glimepiride from binary and ternary solid dispersion formulation. Universal Journal of Pharmaceutical Research 2019; 4(5):7-12.
Sebhatu T, Angberg M and Ahlneck C (1994). Assessment of the degree of disorder in crys-talline solids by isothermal microcalorimetry. Int. J. Pharm., 104: 135-144. (94)
Smithey PGD, Taylor LS. Amorphous solid dispersions: an enablingformulation technology for oral delivery of poorly water solubledrugs. AAPS Newsmag 2013;16:11–14.
Sujja-Areevath., Munday, D.L., Cox, P.J., Khan, K.A., 1998. Relationship between swelling, erosion and drug release in hydrophilic natural gum mini-matrix formulations. Eur. J. Pharm. Sci., 6, 207-217.
Usman Mohammed Jajere, Achadu AE. Fabrication and characterization of ezetimibe solid dispersion for solubility enhancement. Universal Journal of Pharmaceutical Research. 2017; 2(1): 12-16.
Thakur et al; A review on solid dispersion; World Journal of Pharmacy and Pharmaceutical Sciences; 2014; 3(9); 173-187.
Kumar A, Kumar K. Solid dispersion-strategy to enhance solubility and dissolution of poorly water soluble drugs. Universal Journal of Pharmaceutical Research. 2017; 2(5): 54-59.
VermaS ,Rawat A, Kaul M and Saini S: Solid Dispersion: A Strategy For Solubility Enhancement . International Journal of Pharmacy & Technology2011; 3(2): 1062-1099.
Won DH. Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti solvent precipitation process. Int J Pharm. 2005; 301: 199–208.
Yadav B, Tanwar YS. Development, characterization and in vitro evaluation of flurbiprofen solid dispersions using polyethylene glycols as carrier. J App Pharm Sci. 2016; 6 (04): 060-066.
Yoshihashi Y: Estimation of physical stability of amorphous solid dispersion using differential scanning calorimetry. Journal of Thermal Analysis and Calorimetric 2006; 85: 689– 692.
Youn YS. Improved intestinal delivery of salmon calcitonin by Lys18- amine specific PEGylation: Stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy. J Contr Rel. 2006; 334–342.
Zhang R and Somasundaran P. Advances in adsorption of surfactants and their mixtures atsolid/solution interfaces. Advances in colloid and interface science 123-126, 2006, 213-229.(49)
Zhang W, Yan E, Huang Z, Wang C, Xin Y, Zhao Q, and Tong Y. Preparation and study of PPV/PVA nanofibers via electrospinning PPV precursor alcohol solution. European polymer 43,2007, 802-897. (78).
Md. Shahidul Islam, Rasheda Akter Lucky. Development and in vitro dissolution study of binary and ternary solid dispersions of aceclofenac. Universal Journal of Pharmaceutical Research 2019; 4(1): 29-36.
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