A Novel Drug Delivery System: Review on Microspheres
Abstract
Microspheres are multiparticulate drug delivery systems that are designed to deliver drugs to a particular location at a fixed rate. Microspheres are free-flowing powders made up of biodegradable proteins or synthetic polymers with particle sizes ranging from 1 to 1000µm. Benefits of the use of microspheres in fields such as drug delivery, bone tissue manufacturing, and the absorption and desorption of contaminants by regeneration. The study shows the method of planning and measurement of microsphere parameters. Microspheres are complex, such as bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, radioactive microspheres. Microspheres may be used in various fields such as cosmetics, oral drug delivery, target drug delivery, ophthalmic drug delivery, gene delivery, and others listed in the study. In order to achieve optimal therapeutic effectiveness, it is important to deliver the agent to the target tissue at an optimum level within the right timeframe, resulting in little toxicity and minimal side effects. There are different approaches to supplying the medicinal drug to the target site in a continuous managed manner. One such strategy is the use of microspheres as drug carriers. In this article, the value of the microsphere is seen as a novel drug delivery carrier to achieve site-specific drug delivery was discussed.
Keywords: microspheres, method of preparations, polymer, bioadhesion, types of microspheres
Keywords:
microspheres, method of preparations, polymer, bioadhesion, types of microspheresDOI
https://doi.org/10.22270/jddt.v11i2-S.4792References
Chowdary KPR, Yarraguntla SR. Mucoadhesive microsphere for controlled drug delivery. Biological and Pharmaceutical Bulletin 2004; 1717-24.
Inada A, Oue T, Yamashita, Yamasaki M, Oshima T and Matsuyam H. Development of highly water-dispersible complexes between coenzyme Q10 and protein hydrolysates. European Journalof Pharmaceutical Sciences. 2019; 136.
Chaudhari A, Jadhav KR, Kadam VJ. An overview: Microspheres as a nasal drug delivery system. International Journal of Pharmaceutical Sciences Review and Research. 2010 Nov; 5(1).
Jain NK. Controlled and Novel drug delivery; CBS Publishers New Delhi, India; 04 Edition.2004; 236-237, 21.
Venkatesan P, Manavalan R, Valliappan K. Microencapsulation: a vital technique in novel drug delivery system. Journal of Pharmaceutical Sciences and Research. 2009 Dec 1; 1(4):26-35.
Ramteke KH, Jadhav VB, Dhole SN. Microspheres: as carriers used for novel drug delivery system. IOSR Journal of Pharmacy 2012 Jul; 2(4):44-8.
Chein YM. Novel Drug Delivery System, second edition, revised & expanded, Marcel Dekker, Inc, New York 1992
Sachan AK, Gupta A, Arora M, Formulation & characterization of nanostructured lipid carrier (NLC) based gel for topical delivery of etoricoxib, Journal of drug delivery and therapeutics 2016; 6(2):4-13
Verma NK, Alam G, Vishwakarma DK, Mishra JN, Khan WU, Singh AP, Roshan A. Recent Advances in Microspheres Technology for Drug Delivery. International Journal of Pharmaceutical Sciences and Nanotechnology. 2015 May 31; 8(2):2799-813.
Khar R.K, Vyas, S.P. Targeted and Controlled Drug Delivery- Novel Carrier Systems., 1st edition. CBS Publications and Distributors, New Delhi; 2002; 417- 418.
Kreuter J, Nefzger M, Liehl E, Czok R, Voges R. Microspheres – A Novel Approach in Drug Delivery System. Journal of Pharmaceutical sciences.1983; 72:1146.
Singh C, Purohit S, Singh M, Pandey BL. Design and evaluation of microspheres: A Review. Journal of drug delivery research. 2013; 2(2):18-27.
Midha K, Nagpal M, Arora S. Microspheres: a recent update. International Journal of Recent Scientific Research. 2015; Jul: 5859-67.
Sipai AB, Vandanayadav M, Mamatha Y, Prasanth VV. Mucoadhesive Microsphere An overview. American Journal of Pharmaceutical Research. 2012; 2(1):237-58.
Liu G, Yang H, Zhou J, Preparation of magnetic microsphere from water-in-oil emulsion stabilized by block copolymer dispersant. Biomacromolecules. 2005; 6:1280-1288.
Shanthi N.C, Gupta R, Mahato K.A. Traditional and Emerging Applications of Microspheres: A Review, International Journal of Pharm Tech Research.2010; 2(1):675-681.
Najmuddin M, Ahmed A, Shelar S, Patel V, Khan T. Floating Microspheres of Ketoprofen: Formulation and Evaluation, International Journal of Pharmacy and Pharmaceutical sciences.2010; 2(2):83-87.
Hafeli U. Physics and Chemistry Basic of Biotechnology. Focus on biotechnology. Review. Radioactive Microspheres for Medical Application. 2002; 7:213-48.
Yadav AV, Mote HH. Development of Biodegradable Starch Microspheres for Intranasal Delivery, Indian Journal of pharmaceutical Sciences. 2008; 70(2):170-174.
Saralidze K, Leo H, Koole, Menno L, Knetsch W. Polymeric Microspheres for Medical Applications, Materials.2010; 3:3357-3564.
Trivedi P, Vermal, GarudN. Preparation and Characterization of Acelofenac Microspheres, Asian Journal of pharmaceutics.2008; 2(2):110-115.
Nikam VK, Gudsoorkar VR, Hiremath SN, Dolas RT, Kashid VA. Microspheres-A Novel drug delivery system: An overview; International Journal of Pharmaceuticaland chemical sciences. 2012; 1:113-128.
Alagusundaram M, Madhu C, Umashankari K, Attuluri B, Lavanya C, Ramakant S. Microspheres: As novel drug delivery system. International Journal of Chem Tech Research. 2009; 1(3):526-534.
Sinha V R, Singla AK, Wadhawan S, Kaushik R, Kumria R, Bansal K, Dhawan S. Chitosan microspheres as a potential carrier for drugs. International Journal of Pharmaceutics. 2004; 274:1–33.
Jayaprakash S, Halith S M, Mohamed Firthouse P U, Kulaturanpillai K, Abhijith, Nagarajan M. Preparation and evaluation of biodegradable microspheres of methotrexate. Asian Journal of Pharmaceutical sciences.2009; 3:26-9.
Sinha V R, Bansal K, Kaushik R, Kumria R, Trehan A. Poly-caprolactone microspheres and nanospheres. International Journal of Pharmaceutics . 2004; 278 1–23
Kumar A, Jha S, Rawal R, Chauhan PS and Maurya SD. Mucoadhesive microspheres for novel drug delivery system: A Review. American Journal of Pharm Tech Research. 2013; 3(4):197- 13.
Meena KP, Dangi JS, Samal PK, Namedo KP. Recent advances in microsphere manufacturing technology. International Journal of Pharmacy and Technology. 2011; 3(1):854-855.
Kadam NR, Suvarna V. Microsphere: a brief review. Asian Journal of Biomedical and Pharmaceutical Sciences. 2015 Aug 1; 5(47):13.
Thanoo BC, Sunny MC, Jayakrishanan A. Cross-linkedchitosan microspheres: Preparation and evaluation as a matrix for the controlled release of pharmaceuticals. Journal of Pharmacy and Pharmacology. 1992; 44:283-286
Parmar H, Bakliwal S, Gujarathi N, Rane B, Pawar S. Different method of formulation and evaluation of mucoadhesive microsphere. International Journal of Applied Biology and Pharmaceutical Technology. 2010; 1(3):1157-1167.
Moy AC, Mathew ST, Mattapan R, Prasanth VV. Microsphere-An Overview. International Journal of Pharmaceutical and Biomedical Sciences. 2011; 2(2):332-338.
Alagusundaram M, Chetty MSC, Umashankari K, Badarinath AV, Lavanya C, Ramakant S. Microspheres as a Novel Drug Delivery System- A Review. International Journal of Chem. Tech Research.2009; 1:526-34
Singh C, Purohit S, Singh M, Pandey B.L. Design and evaluation of microspheres: A Review, Journal of Drug Development and Research 2013; 2(2):18- 27.
Sahil K, Akanksha M, Premjeet S, Bilandi A, Kapoor B. Microsphere: A review. International Journal of Research in Pharmacy and Chemistry 2011; 1(11):84-98.
Pavan K. B, Chandiran I.S, Bhavya B, Sindhuri M. Microparticulate drug delivery system: A Review. Indian journal of pharmaceutical science & research. 2011; 1(1):19- 37
Dhakar R.C, Maurya S.D, Sagar B.P.S, Bhagat S, Prajapati S.K, Jain C.P. Variables influencing the drug entrapment efficiency of microspheres: A pharmaceutical review. Der Pharmacia Lettre. 2010; 2(5):102-116.
Gogu P.K. Preparation & invivo characterization of spray dried Microspheres formulation Encapsulating 4- chlorocurcumin. Indian Journal of Pharmaceutical sciences. 2010; 72:346-352.
Alagusundaram M, Chetty MS, Umashankari K, Badarinath AV, Lavanya C, Ramkanth S. Microspheres as a novel drug delivery system: A review. International Journal of Chem Tech Research. 2009; 1(3):526-534.
Patel NR, Patel DA, Bharadia PD, Pandya V, Modi V. Microsphere as a novel drug deliver. International Journal of Pharmacy & Life Sciences. 2011; 2(8).
Thadanki M, Chadalawada PK, Lavanya P., Umashankar D: Formulation and evaluation of sustained release saxagliptin microspheres by ionotropic gelation method. International Journal of Bioassays. 2017; pg. no. 5328-5333.
Dupinder K, Saini Seema S: Variable Effecting Drug Entrapment Efficiency of Microspheres: A Review. International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS); 2013; 3(3):24-28.
Sailaja A, Anusha K. Review on microspheres as a drug delivery carrier. International Journal of Advances in Pharmaceutics 2017; 06(05):96-102.
Tarun V, Gupta J. Pharmaceutical Application of Microspheres: An Approach for the Treatment of Various Diseases; International Journal of Pharmaceutical Sciences and Research, 2017; 8(1):3257- 3259.
Sharma N, Purwar N. and Gupta PC. Microspheres as Drug Carriers for Controlled Drug Delivery: A Review. International Journal of Pharmaceutical Sciences and Research 2015; 6(11):4579-87
Pradeesh TS, Sunny MC, Varma HK, Ramesh P. Preparation of microstructure hydroxyapatite microspheres using oil in water emulsions. Bull Materials Sci. 2005; 28:383-90
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