DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF LEVOFLOXACIN HYDROCHLORIDE

  • Amit Chaudhary Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology By-Pass Road, Partapur, Meerut-250103, Uttar Pradesh, India
  • Upendra Nagaich Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology By-Pass Road, Partapur, Meerut-250103, Uttar Pradesh, India
  • Bhavya Rastogi Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology By-Pass Road, Partapur, Meerut-250103, Uttar Pradesh, India
  • Neha Gulati Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology By-Pass Road, Partapur, Meerut-250103, Uttar Pradesh, India
DOI https://doi.org/10.22270/jddt.v2i6.332

Abstract

Levofloxacin microspheres with  mucoadhesive polymers like Sodium Alginate, Sodium Carboxymethyl Cellulose and Carbopol-940 were prepared by w/o emulsification solvent evaporation method and evaluated. The resulting microspheres were small, discrete, spherical and free flowing. The microspheres showed significant mucoadhesive property in the in-vitro wash-off test. The drug release from the mucoadhesive microspheres followed the controlled release profile. and first order kinetics. Drug release was controlled by the diffusion mechanism. Stability studies were performed at three different temperatures for six weeks. All the formulation showed satisfactory stability profile.

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How to Cite
1.
Chaudhary A, Nagaich U, Rastogi B, Gulati N. DEVELOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF LEVOFLOXACIN HYDROCHLORIDE. JDDT [Internet]. 11Nov.2012 [cited 2May2024];2(6). Available from: https://www.jddtonline.info/index.php/jddt/article/view/332
Issue
Vol 2 No 6 (2012): Volume 2, Issue 6, Nov-Dec 2012
Section
Research

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