PREPARATION AND IN VITRO CHARACTERIZATION OF ACETAMINOPHEN BY SOLID SOLUTION TECHNIQUE
Abstract
Abstract:
Paracetamol (PCM) is poor water soluble drug which comes under Biopharmaceutical classification system (BCS) class III, having (log p =0.5) and shows dissolution rate limited absorption. The solid dispersion of this using PEG 4000 as a carrier in different ratio prepared by using trituration method and solidification technique followed by a formation of a solid solution phase. The prepared dispersions characterized for a solubility study, drug content analysis, in-vitro release profile and stability study. The drug content was found to be high in formulation F4 due to the high carrier ratio which causes the creation of a highly hydrophilic environment. The stability study of formulated dispersions also explains the PEG 4000 is a better choice for this study and does not changes its physical as well as chemical property on being storage. The prepared dispersion by this technique improved the dissolution rate as well as solubility of the prepared dispersion when compared with the raw drug (RD) and physical mixture (PM).
Key words: Paracetamol, BCS class III , PEG 4000, Solid solution
DOI
https://doi.org/10.22270/jddt.v2i5.264
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