OIL ENTRAPPED FLOATING MULTIPARTICULATE SYSTEM OF CIPROFLOXACIN USING SODIUM ALGINATE BY EMULSION GELATION TECHNIQUE
Abstract
The objective of this present work is to develop gastroretentive multiunit emulsion beads based on the oil for the sustaining effect of the Ciprofloxacin (CPX). By the technique which is based on emulsion gelation technique different oil was taken and incorporated in the mixture of CPX and sodium alginate (SA) as a hydrophilic polymer and this is extruded with the help of syringe in 4 % calcium chloride cross linking solution having curing time of 10 min.
Prepared emulsion beads show a better portfolio in terms of drug release. The conventional emulsion beads (F4) shows a burst effect due to no incorporation of oil in it. Use of oil in the formulation acts as a barrier with SA and prolongs the effect of drug in the upper GI tract for a longer period of time and may be used in the treatment of upper GI tract infection.
Other formulations in which oil used (F1, F2. F3) proves a better sustaining effect as compared to formulation (F4) and it was found that sodium alginate not only effective for the sustaining effect of drug alone. With use of oil and sodium alginates it proves a better polymer for this drug.
Data obtained from our present investigation we find out that retardation of the drug from the matrixes of drug in following order mentha oil > light liquid paraffin > castor oil and also explains the better encapsulation efficiency, % buoyancy and release profile.
Key words: Ciprofloxacin, Sodium alginate, emulsion gelation technique, curing time, upper GI tract, encapsulation efficiency, % buoyancy, release profile
DOI
https://doi.org/10.22270/jddt.v2i5.258
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