Evaluation of Ayurvedic formulation for Pharmacognostic parameters, Phytochemical screening, and acute toxicity
Abstract
In this age, there is an urgent need to meticulously examine the present indisputable conclusion on traditional herbal medicines, which are used for a favourable outcome for various maladies. Therefore the current investigation aimed to formulate traditional Ayurvedic medicine Amrtabhallataka Ghrta. (ABG) and evaluate it for pharmacognostic, phytochemistry and acute toxicity on Wistar rats. The organoleptic and microscopical features of Semecarpus anacardium were studied. Further, Bhallantaka nut was evaluated for phytochemical constituents. After the Shodhana process, Amrtabhallataka Ghrita was prepared. Further Ghrita was analysed for its organoleptic, physicochemical features and screened its acute toxicity in Wistar rats. The progress in analytical methodologies could serve as a specific basis for examination in herbal drug technology, thereby, aid the Ayurvedic industry to lay down quality standards and parameters, for the establishment of therapeutic efficacy, safety and purity of herbal drugs.
Keywords: Semecarpus anacardium, Ghrita Standardization, Herbal ghee, Ayurvedic medicine Acute Toxicity
DOI
https://doi.org/10.22270/jddt.v9i2-s.2566References
Archana SK, and Satpute K, “A review on vajikarana: the special branch in Ayurveda,” Int. J. Res. Ayurveda Pharm, 2017; (8)3:60-62.
Sandberg F, Corrigan D. Natural Remedies. Their Origins and Uses. Abingdon: Taylor & Francis; 2001.
Mary NK, Babu BH, Padikkala J, “Antiatherogenic effect of Caps HT2, A herbal Ayurvedic medicine formulation,” Phytomedicine, 2003; 10(6):474-482.
Nair PKR, Steven J, Melnick Stanislaw F, Wnuk, Magdalena Rapp, Enrique Escalon, et al. Isolation and characterization of an anticancer catechol compound from Semecarpus anacardium. J Ethnopharmacol 2009; 122:450–6.
Ramprasath VR, Shanthi P, Sachdanandam P, “Immunomodulatory and anti-inflammatory effects of Semecarpus anacardium Linn. Nut milk extract in experimental inflammatory conditions,” Biol Pharm Bull, 2006; 29:693-700.
Verma N; Vinayak M, “Semecarpus anacardium nut extract promotes the antioxidant defense system and inhibits anaerobic metabolism during development of lymphoma,” Biosci Rep, 2009; 29(3):151-64
Mohanta TK, Patra JK, Rath SK, Pal DK, Thatoi HN , “Evaluation of antimicrobial activity and phytochemical screening of oils and nuts of Semecarpus anacardium,” Sci Res Essay, 2007; 2:486-90.
Arul B, Kothai R, Christina A J , “Hypoglycaemic and antihyperglycemic effect of Semecarpus anacardium Linn in normal and streptozotocin-induced diabetic rats,” Methods Find Exp Clin Pharmacol. 2004 26:759-762. .
Kothai R, Arul B, Kumar KS, Christina A J, “Hypoglycaemic and antihyperglycemic effects of Semecarpus anacardium Linn in normal and alloxan - induced diabetic rats,” J Herb Pharmacother. 2005; 5 (2):49-56.
Smith F, Woerdenbag HJ, Singh R H, Meulenbeld GJ, Labadie RP, Zwaving J H. Ayurvedic herbal drugs with possible cytostatic activity. J Ethnopharmacol. 1995; 47(2):75-84.
Mohapatra S, Reddy KR, Jha CB. Historical review of Svarna Mãksika. Bull Indian Inst Hist Med Hyderabad. 2007; 37(2):153-66.
Premalatha B. Semecarpus anacardium Linn. nuts— a boon in alternative medicine. Indian J Exp Biol. 2000; 38(12):1177-82.
Rasheed A, Reddy B S, Roja C A REVIEW ON STANDARDISATION OF HERBAL FORMULATION Inter. J. of Phytotherapy 2012; 2(2):74-88.
Panchawat S , Rathore K S, Sisodia N R K, “Standardization and evaluation of herbal drug formulations,” 2010
Kirtikar KR, Basu BD. Indian Medicinal Plants: (2nd Ed). Vol. II, M/S Bishen Singh Mahendra Pal Singh; 1935. 1294-1295
Khandelwal KR. Practical Pharmacognosy Techniques and Experiments Nirali Prakashan Pune. 2008; 38:9-15.
Sumanlatha G. Laboratory Manual for Pharmacognosy: Pharmacognosy Characters. Create space Independent Publishing Platform, New York, 2017, 28-35
Wallis TE. Text Book of Pharmacognosy. 5 th ed. New Delhi: CBS Publishers; 1985. 571
Harborne JB. Phytochemical methods, London. Chapman and Hall, Ltd, 1973, 49-188.
Nutan, Kumar N, Saxena G Cytotoxic effect of Hemidesmus indicus R. Br. on HCT 116 human colon cell lines, The Pharma Innovation Journal 2019; 8(1):86-89
Anonymous. Ayurvedic Pharmacopoeia of India, Part-1, Vol-2. New Delhi: Govt. of India, Ministry of Health of Family Welfare; Department of Indian Systems of Medicine and Homeopathy, NEW DELHI: The Controller of Publication 2004.
Anonymous-The Ayurvedic Formulary of India, second revised English edition, Govt. Of INDIA Ministry of Health and Family Welfare, Department of Indian Systems of Medicine and Homeopathy, NEW DELHI: Published by The Controller of Publications Civil Lines Delhi; 2003.Part-1, 6 thSection , 80pp
OECD Guidelines for the testing of chemicals: 423; 2001. Acute oral toxicity- Acute Toxic Class Method
Rufino, M. S., Alves, R. E., Brito, E. S., Pérez-Jiménez, J., Saura-Calixto, F., Mancini-Filho, J. Bioactive compounds and antioxidant capacities of 18 non-traditional tropical fruits from Brazil. Food Chemistry, 2010, 121, 996–1002.
Murty GK. Clinical toxicity study of Semecarpus anacardium Linn. f. Indian J Exp Biol; 1974; 12(5):444-6.
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