OPTIMIZATION OF THE RELEASE KINETICS OF DILTIAZEM HYDROCHLORIDE FROM TABLETED MICROSPHERES
Abstract
Formulation F5, F6, F7 and F8 were selected to make the tablets because of their high percentage release (more than 90%). 500 mg weight of tablets containing 120 mg strength of Diltiazem hydrochloride were prepared from formulations F5, F6, F7 and F8. release of Diltiazem hydrochloride at different interval of time: 1 hr, 4 hrs, 8 hrs and 12 hrs for different formulations, it can be concluded that more than 90% of Diltiazem hydrochloride was released from formulations F1, F3, F5, F6, F7, F8, F9, F11 at 12 hours. After compaction into the tableted form, the dissolution or release of the drug will reduce. Hence, these formulations may be compressed into the tablet forms so that the release should be around or more than 80%. Some analytical definitions of the Q(t) function are commonly used, such as zero order, first order, Higuchi, Korsmeyer-Peppas, Hixson-Crowell models, Weibull model, Baker – Lonsdale model, Hopfenberg model, etc. These models are used to characterize drug dissolution/release profiles.
Keywords: Optimization, Microsphere, Diltiazem hydrochloride, Higuchi, Korsmeyer-Peppas, Hixson-Crowell models.
DOI
https://doi.org/10.22270/jddt.v8i1.1551
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