FTIR SPECTROSCOPIC METHOD FOR QUANTITATIVE ANALYSIS OF GLICLAZIDE IN TABLETS

Authors

  • P G Sunitha College of Pharmacy, Madras Medical College, Chennai-600 003,Tamil Nadu, India
  • N Deattu College of Pharmacy, Madras Medical College, Chennai-600 003,Tamil Nadu, India
  • C Balachandar College of Pharmacy, Madras Medical College, Chennai-600 003,Tamil Nadu, India
  • P Nandhini College of Pharmacy, Madras Medical College, Chennai-600 003,Tamil Nadu, India
  • R Narayane College of Pharmacy, Madras Medical College, Chennai-600 003,Tamil Nadu, India
  • M Senthamil Kavitha College of Pharmacy, Madras Medical College, Chennai-600 003,Tamil Nadu, India
  • D Sivakumar College of Pharmacy, Madras Medical College, Chennai-600 003,Tamil Nadu, India

Abstract

A rapid FTIR spectroscopic method has been proposed for the estimation of Gliclazide in bulk drug and pharmaceutical dosage form. The method involves the measurement of the area of the infrared band corresponding to the amide stretching centered at 3317cm-1. The excipients in the commercial tablet preparation did not interfere with the assay. The linearity range was found to be 4-24µg/ml. The technique is reliable and useful for quality control for monitoring the adulteration of pure drug. The proposed method is statistically validated and found to be useful for the routine determination of gliclazide in tablets.

Keywords:Gliclazide, FTIR, Tablets, Validation.

DOI

https://doi.org/10.22270/jddt.v4i3.872

Published

2014-05-15
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How to Cite

1.
Sunitha PG, Deattu N, Balachandar C, Nandhini P, Narayane R, Kavitha MS, et al. FTIR SPECTROSCOPIC METHOD FOR QUANTITATIVE ANALYSIS OF GLICLAZIDE IN TABLETS. J. Drug Delivery Ther. [Internet]. 2014 May 15 [cited 2026 Jan. 18];4(3):145-6. Available from: https://www.jddtonline.info/index.php/jddt/article/view/872

Issue

Vol. 4 No. 3 (2014): Volume 4, Issue 3, May-June 2014

Section

Research

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How to Cite

1.
Sunitha PG, Deattu N, Balachandar C, Nandhini P, Narayane R, Kavitha MS, et al. FTIR SPECTROSCOPIC METHOD FOR QUANTITATIVE ANALYSIS OF GLICLAZIDE IN TABLETS. J. Drug Delivery Ther. [Internet]. 2014 May 15 [cited 2026 Jan. 18];4(3):145-6. Available from: https://www.jddtonline.info/index.php/jddt/article/view/872
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