PREPARATION AND CHARACTERIZATION OF SOLID DISPERSION OF MODAFINIL USING PEG6000 AS HYDROPHILIC CARRIER FOR IMPROVEMENT OF DISSOLUTION PROFILE
Abstract
Solid dispersions of modafinil were prepared using polyethyleneglycols, in various proportions by melting, solvent evaporation and kneading method. Based on the solubility, PEG6000 was selected and solid dispersion batch F6 containing drug:PEG6000 in 1:3 ration was formulated as tablet (batch TF6) and evaluated for in-vitro drug dissolution and six month stability; and the results were compared with that of tablet containing physical mixture of drug:PEG6000 in 1:3 ratio (batch TF24) and convention tablet (batch CT) containing pure drug. Tablet batch TF24 had shown significant improvement of dissolution profile of modafinil when compared with that of tablet batch TF6 and CT. Present study conclusively demonstrated that PEG6000 enhanced water solubility of modafinil by amorphisation, which was confirmed XRD and DSC; and also the melting method was found better than solvent evaporation.
DOI
https://doi.org/10.22270/jddt.v4i3.845Published
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