DEVELOPMENT AND IN VITRO EVALUATION OF FAST DISSOLVING TABLETS OF TIZANIDINE HYDROCHLORIDE BY DIRECT COMPRESSION METHOD

Abstract

In the present work, fast dissolving tablets (FDTs) have been prepared by direct compression method using Tizanidine hydrochloride as a drug candidate. Tizanidine HCl is a centrally acting α-2 adrenergic agonist muscle relaxant with a slightly bitter taste having short half-life of 2.5 h. The tablets were prepared with three superdisintegrants e.g. sodium starch glycolate, crosscarmellose sodium and crospovidone. Formulations were evaluated for pre compression parameters such as bulk density, tapped density, angle of repose, Carr’s index and Hausner’s ratio. The prepared tablets were also evaluated for hardness, friability, thickness, drug content, disintegration time, wetting time and in-vitro dissolution studies. The compatibility of drug with other ingredients was checked by FTIR studies. In-vitro release is presented by zero order and first order plot. From the point of view of maximum drug release within 20 minutes, formulation TZN8 within 8 formulations is the best and hence optimized one. From this study it was concluded that fast dissolving tablets prepared by direct compression method using different superdisintegrants enhanced dissolution which will lead to improved bioavailability and effectiveness of tizanidine hydrochloride.