Ice-Cream Soda Flavoured Effervescent Granules Containing Fennel and Coriander: A Preliminary Formulation Study

Authors

Abstract

Background: Gastric discomfort is a common implication and the poor palatability of conventional antacid formulations often results in reduced compliance. Objectives: To develop dessert-inspired effervescent granules incorporating Foeniculum vulgare (fennel) and Coriandrum sativum (coriander) as mild carminatives. Materials and Methods: A balanced citric acid–tartaric acid–sodium bicarbonate system was utilized to produce controlled effervescence for enhanced patient acceptability. The formulation utilized sodium bicarbonate as a mild antacid and a taste-masking system comprising sucralose, vanillin, maltodextrin, and mannitol to impart a pleasant ice cream soda flavour. Effervescent granules were prepared using the dry blending method. The study included physicochemical characterization of the herbal powders and preliminary evaluation of the granules for flow properties, effervescence time, pH, and preliminary short-term stability. Results: The developed formulation exhibited rapid effervescence and enhanced palatability. The inclusion of natural carminatives along with a mild antacid ensures safety and suitability. The granules represent a promising, palatable, and effective alternative to conventional formulations, with potential to improve compliance. Conclusion: The present study demonstrates a proof-of-concept effervescent formulation integrating herbal carminatives with an ice-cream soda flavoured taste-masking system, highlighting its potential for improved palatability and patient acceptability.

Keywords: Dry Blending Method, Effervescent granules, Gastric discomfort, Herbal Carminatives, Taste masking

Keywords:

Dry Blending Method, Effervescent granules, Gastric discomfort, Herbal Carminatives, Taste masking

DOI

https://doi.org/10.22270/jddt.v16i9.7956

Author Biographies

Irene Nethala, Department of Pharmaceutics, Shantha College of Pharmacy, Chikkaballapur, Karnataka, India.

Assistant Professor, Department of Pharmaceutics, Shantha College of Pharmacy, Chikkaballapur, Karnataka, India.

Misba Aliya , Department of Pharmaceutics, Shantha College of Pharmacy, Chikkaballapur, Karnataka, India.

Department of Pharmaceutics, Shantha College of Pharmacy, Chikkaballapur, Karnataka, India.

Deeksha Vijay Kumar , Department of Pharmaceutics, Shantha College of Pharmacy, Chikkaballapur, Karnataka, India.

Department of Pharmaceutics, Shantha College of Pharmacy, Chikkaballapur, Karnataka, India.

Sunil Kumar Busi , HOD, Department of Pharmaceutical Chemistry, Shantha College of Pharmacy, Chikkaballapur, Karnataka

Professor and HOD, Department of Pharmaceutical Chemistry, Shantha College of Pharmacy, Chikkaballapur, Karnataka 

Gopinath Elumalai, Principal, Shantha College of Pharmacy, Chikkaballapur, Karnataka, India.

Principal, Shantha College of Pharmacy, Chikkaballapur, Karnataka, India.

References

1. Schluterman HM, Linardos CG, Drulia T, Marshall JD, Kearns GL. Evaluating palatability in young children: a mini-review of relevant physiology and assessment techniques. Front Pediatr. 2024;12:1350662. https://doi.org/10.3389/fped.2024.1350662 PMid:38390280 PMCid:PMC10881860

2. Malkawi WA, AlRafayah E, AlHazabreh M, AbuLaila S, Al-Ghananeem AM. Formulation challenges and strategies to develop pediatric dosage forms. Children (Basel). 2022;9(4):488. https://doi.org/10.3390/children9040488 PMid:35455532 PMCid:PMC9027946

3. Ogbonna JDN, Cunha E, Attama AA, Ofokansi KC, Ferreira H, Pinto S, et al. Overcoming challenges in pediatric formulation with a patient-centric design approach: a proof-of-concept study on the design of an oral solution of a bitter drug. Pharmaceuticals (Basel). 2022;15(11):1331. https://doi.org/10.3390/ph15111331 PMid:36355503 PMCid:PMC9694284

4. Aulton ME, Taylor KMG. Aulton’s Pharmaceutics: The Design and Manufacture of Medicines. 5th ed. London: Elsevier; 2018.

5. Allen LV, Ansel HC. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2014.

6. Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients. 8th ed. London: Pharmaceutical Press; 2017.

7. Sundaramoorthy A, Rajappan V, Durisamy R, Ravi R, Chandramohan V, Balakrishnan B, et al. Effervescent tablets: comprehensive review on formulation strategies, manufacturing technologies, and quality evaluation. Int J Innov Sci Res Technol. 2025;10(12):1846-1855. https://doi.org/10.38124/ijisrt/25dec989

8. Patel S, Siddaiah M. Formulation and evaluation of effervescent tablets: a review. J Drug Deliv Ther. 2018;8(6):296-303. doi:10.22270/jddt.v8i6.2021. https://doi.org/10.22270/jddt.v8i6.2021

9. Rather MA, Dar BA, Sofi SN, Bhat BA, Qurishi MA. Foeniculum vulgare: a comprehensive review of its traditional use, phytochemistry, pharmacology and safety. Arab J. Chem. 2016;9:S1574-S1583 https://doi.org/10.1016/j.arabjc.2012.04.011[1]

10. Patel MK, Jain A. Coriandrum sativum: review of its botany, medicinal uses, pharmacological activities and phytochemistry. J Drug Deliv Ther. 2025;15(8):294-302. https://doi.org/10.22270/jddt.v15i8.7340

11. Sharma P, Garg A, Pandey P. Formulation and evaluation of herbal effervescent granules incorporated with Martynia annua extract. J Drug Discov Ther. 2013;1(5):54-57.

12. Devi J, Das B. Preparation and evaluation of ibuprofen effervescent granules. Asian J Pharm Clin Res. 2019;12(18):52-55. https://doi.org/10.22159/ajpcr.2019.v12i8.33994

Published

2026-09-15
Statistics
Abstract Display: 0
PDF Downloads: 0
PDF Downloads: 0

How to Cite

1.
Nethala I, Aliya M, Vijay Kumar D, Busi SK, Elumalai G. Ice-Cream Soda Flavoured Effervescent Granules Containing Fennel and Coriander: A Preliminary Formulation Study. J. Drug Delivery Ther. [Internet]. 2026 Sep. 15 [cited 2026 Sep. 15];16(9):29-34. Available from: https://www.jddtonline.info/index.php/jddt/article/view/7956

How to Cite

1.
Nethala I, Aliya M, Vijay Kumar D, Busi SK, Elumalai G. Ice-Cream Soda Flavoured Effervescent Granules Containing Fennel and Coriander: A Preliminary Formulation Study. J. Drug Delivery Ther. [Internet]. 2026 Sep. 15 [cited 2026 Sep. 15];16(9):29-34. Available from: https://www.jddtonline.info/index.php/jddt/article/view/7956