Antifungal Activity of the Ethanol Extract of Terminalia laxiflora Engl. (Combretaceae) from the Eastern Logone Province of Chad
Abstract
Introduction: Infections caused by pathogenic filamentous fungi are a real public health problem. These germs develop resistance to standard antifungals. Medicinal plants are an important source of secondary metabolites. To address these issues, this study was carried out to evaluate the antifungal activity of the ethanolic extract of Terminalia laxiflora Engl (Combretaceae) from the Eastern Logone province in Chad. Materials and methods: For this study, we used the bark and roots of Terminalia laxiflora Engl. The extract was obtained by maceration from these different parts of the plant. The antifungal activity was evaluated using the agar incorporation method to determine the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC). Additionally, a phytochemical analysis was carried out to establish a correlation between the chemical structure of the compounds and their biological activities. Results: the extraction yield ranged from 9.89 to 18.37%. Phytochemical screening of the bark and roots of Terminalia laxiflora Engl. revealed the presence of flavonoids, gallic tannins, saponins, alkaloids, heterosides, free quinones, anthraquinones, sterols, terpenoids, and anthocyanins. These extracts inhibited the growth of Aspergillus flavus, Aspergillus niger, Trichophyton rubrum, Trichophyton soudanense, and Microsporum canis, with minimum inhibitory concentrations (MIC) ranging from 1 mg/mL to 3 mg/mL. Conclusion: The extract from Terminalia laxiflora Engl. will be a potential source of secondary metabolites with antifungal activity.
Keywords: activity, antifungal, Terminalia laxiflora Engl., Eastern Logone, Chad
Keywords:
antifungal activity, Terminalia laxiflora Engl., Eastern Logone, ChadDOI
https://doi.org/10.22270/jddt.v16i8.7949References
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Copyright (c) 2026 Bégoto Mbailassem, Issakou Bakarnga-Via, Roberto Alladoum, Mahamat Hadja Ibrahim , Nadlaou Bessimbaye
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