Pectin as a Value-Added Biopolymer from Fruit Processing Waste: Structural Features, Extraction Methods, and Health Applications

Authors

  • Harsh Himalayan Institute of Pharmacy, Kala amb, Himachal Pradesh, India.
  • Sakshi Tomer Himalayan Institute of Pharmacy, Kala amb, Himachal Pradesh, India.
  • Rambabu Sharma Himalayan Institute of Pharmacy, Kala amb, Himachal Pradesh, India.

Abstract

Interest in valuing fruit processing by-products as sources of high-value biopolymers has increased due to growing concerns about environmental sustainability and the production of food waste. Because of its structural diversity, wide range of functional applications, and abundance in fruit wastes, pectin has emerged as one of these promising value-added polysaccharides. Higher plants the central lamella and main cell wall are largely composed of pectin, a complex heteropolysaccharide high in galacturonic acid. The fruit juice and canning industries produce large amounts of wastes that are rich in pectin, especially from apple pomace and citrus peels, which provide a cost-effective and environmentally friendly substrate for pectin extraction. An extensive summary of pectin's structural characteristics, compositional domains, and impact on functional properties is given in this review. The yield, efficiency, and environmental impact of several traditional and cutting-edge extraction methods including enzymatic, acidic, microwave-assisted, and ultrasound-assisted methods are examined critically. The review also emphasises the health benefits of pectin, which are primarily mediated through altering gut microbiota and metabolic pathways. These benefits include antihyperglycemic, antihyperlipidemic, anti-obesity, cardioprotective, immunomodulatory, and anticancer properties. Pectin's uses in industry, medicine, and nutraceuticals are also examined, with particular attention paid to its functions as a gelling agent, stabiliser, binder, controlled-release polymer, and prebiotic dietary fibre. Overall, this review highlights pectin's potential as a sustainable biopolymer made from fruit processing waste that can be used to develop functional foods, reduce waste, and improve drug delivery systems.

Keywords: Pectin; Biopolymer; Nano drug delivery; Prebiotic; Sustainable extraction

Keywords:

Pectin, Biopolymer, Nano drug delivery, Prebiotic, Sustainable extraction

DOI

https://doi.org/10.22270/jddt.v16i7.7894

Author Biographies

Harsh, Himalayan Institute of Pharmacy, Kala amb, Himachal Pradesh, India.

Himalayan Institute of Pharmacy, Kala amb, Himachal Pradesh, India.

Sakshi Tomer , Himalayan Institute of Pharmacy, Kala amb, Himachal Pradesh, India.

Himalayan Institute of Pharmacy, Kala amb, Himachal Pradesh, India.

Rambabu Sharma , Himalayan Institute of Pharmacy, Kala amb, Himachal Pradesh, India.

Himalayan Institute of Pharmacy, Kala amb, Himachal Pradesh, India.

References

1. Freitas CMP, Coimbra JSR, Souza VGL, et al. Structure and applications of pectin in food, biomedical, and pharmaceutical industry: A review. Coatings. 2021;11:922. doi:10.3390/coatings11080922

2. Zdunek A, Pieczywek PM, Cybulska J. The primary, secondary, and structures of higher levels of pectin polysaccharides. Compr Rev Food Sci Food Saf. 2021;20:1101–1117. doi:10.1111/1541-4337.12689

3. Picot-Allain MCN, Ramasawmy B, Emmambux MN. Extraction, characterisation, and application of pectin from tropical and sub-tropical fruits: A review. Food Rev Int. 2022;38:282–312. doi:10.1080/87559129.2020.1733008

4. Dominiak M, Søndergaard KM, Wichmann J, et al. Application of enzymes for efficient extraction, modification, and development of functional properties of lime pectin. Food Hydrocoll. 2014;40:273–282. doi:10.1016/j.foodhyd.2014.03.012

5. Basak S, Annapure US. Trends in “green” and novel methods of pectin modification: A review. Carbohydr Polym. 2022;278:118967. doi:10.1016/j.carbpol.2021.118967

6. Chandel V, Biswas D, Roy S, et al. Current advancements in pectin: Extraction, properties and multifunctional applications. Foods. 2022;11:2683. doi:10.3390/foods11172683

7. Salima B, Seloua D, Djamel F, et al. Structure of pumpkin pectin and its effect on its technological properties. Appl Rheol. 2022;32:34–55. doi:10.1515/arh-2022-0124

8. Gawkowska D, Cybulska J, Zdunek A. Structure-related gelling of pectins and linking with other natural compounds: A review. Polymers. 2018;10:762. doi:10.3390/polym10070762

9. Humerez-Flores JN, Verkempinck SH, De Bie M, et al. Understanding the impact of diverse structural properties of homogalacturonan-rich citrus pectin-derived compounds on their emulsifying and emulsion stabilizing potential. Food Hydrocoll. 2022;125:107343. doi:10.1016/j.foodhyd.2021.107343

10. Mao Y, Lei R, Ryan J, et al. Understanding the influence of processing conditions on the extraction of rhamnogalacturonan-I “hairy” pectin from sugar beet pulp. Food Chem X. 2019;1:100026. doi:10.1016/j.fochx.2019.100026

11. Yapo BM. Pectin rhamnogalacturonan II: On the “small stem with four branches” in the primary cell walls of plants. Int J Carbohydr Chem. 2011;2011:964521. doi:10.1155/2011/964521

12. Begum RA, Fry SC. Arabinogalactan-proteins as boron-acting enzymes, cross-linking the rhamnogalacturonan-II domains of pectin. Plants (Basel). 2023;12:3921. doi:10.3390/plants12233921

13. Jensen JK, Sørensen SO, Harholt J, et al. Identification of a xylogalacturonan xylosyltransferase involved in pectin biosynthesis in Arabidopsis. Plant Cell. 2008;20:1289–1302. doi:10.1105/tpc.107.050906

14. Thakur BR, Singh RK, Handa AK, Rao MA. Chemistry and uses of pectin—A review. Crit Rev Food Sci Nutr. 1997;37:47–73. doi:10.1080/10408399709527767

15. Sandarani M. A review: Different extraction techniques of pectin. J Pharmacogn Nat Prod. 2017;3:143. doi:10.4172/2472-0992.1000143

16. Mollea C, Chiampo F, Conti R. Extraction and characterization of pectins from cocoa husks: A preliminary study. Food Chem. 2008;107:1353–1356. doi:10.1016/j.foodchem.2007.09.006

17. Shi X, Chang K, Schwarz J, Wiesenborn D, Shih M. Optimizing pectin extraction from sunflower heads by alkaline washing. Bioresour Technol. 1996;58:291–297. doi:10.1016/S0960-8524(96)00120-4

18. Funami T, Nakauma M, Ishihara S, Tanaka R, Inoue T, Phillips GO. Structural modifications of sugar beet pectin and the relationship of structure to functionality. Food Hydrocoll. 2011;25:221–229. doi:10.1016/j.foodhyd.2009.11.017

19. Cui SW, Chang YH. Emulsifying and structural properties of pectin enzymatically extracted from pumpkin. LWT Food Sci Technol. 2014;58:396–403. doi:10.1016/j.lwt.2014.03.015

20. Petkowicz CL, Vriesmann LC, Williams PA. Pectins from food waste: Extraction, characterization and properties of watermelon rind pectin. Food Hydrocoll. 2017;65:57–67. doi:10.1016/j.foodhyd.2016.10.040

21. Franchi ML, Marzialetti MB, Pose GN, Cavalitto SF. Evaluation of enzymatic pectin extraction by a recombinant polygalacturonase (PGI) from apples and pears pomace of Argentinean production and characterization of the extracted pectin. J Food Process Technol. 2014;5:352. doi:10.4172/2157-7110.1000352

22. Yang J-S, Mu T-H, Ma M-M. Extraction, structure, and emulsifying properties of pectin from potato pulp. Food Chem. 2018;244:197–205. doi:10.1016/j.foodchem.2017.10.059

23. Gawkowska D, Cybulska J, Zdunek A. Structure-related gelling of pectins and linking with other natural compounds: A review. Polymers (Basel). 2018;10:762. doi:10.3390/polym10070762

24. Lara-Espinoza C, Carvajal-Millán E, Balandrán-Quintana R, López-Franco Y, Rascón-Chu A. Pectin and pectin-based composite materials: Beyond food texture. Molecules. 2018;23:942. doi:10.3390/molecules23040942

25. Ishii T. Feruloyl oligosaccharides from cell walls of suspension-cultured spinach cells and sugar beet pulp. Plant Cell Physiol. 1994;35:701–704. doi:10.1093/oxfordjournals.pcp.a078658

26. Bunzel M, Ralph J, Lu F, Hatfield RD, Steinhart H. Lignins and ferulate–coniferyl alcohol cross-coupling products in cereal grains. J Agric Food Chem. 2004;52:6496–6502. doi:10.1021/jf048690z

27. Yoo SH, Lee BH, Lee H, et al. Structural characteristics of pumpkin pectin extracted by microwave heating. J Food Sci. 2012;77:C1169–C1173. doi:10.1111/j.1750-3841.2012.02953.x

28. Li D-Q, Du G-M, Jing W-W, Li J-F, Yan J-Y, Liu Z-Y. Combined effects of independent variables on yield and protein content of pectin extracted from sugar beet pulp by citric acid. Carbohydr Polym. 2015;129:108–114. doi:10.1016/j.carbpol.2015.04.051

29. Rambabu S, Ranawat MS, Bhandari A, Dinesh P. The study of Guar gum and starch on disintegration time and drug release of fast dissolving tablet in rabbit using single dose randomized parallel design method. Jordan Journal of Pharmaceutical Sciences. 2013 Oct 8;6(3):280-91.

30. Drusch S. Sugar beet pectin: A novel emulsifying wall component for microencapsulation of lipophilic food ingredients by spray-drying. Food Hydrocoll. 2007;21:1223–1228. doi:10.1016/j.foodhyd.2006.10.006

31. Iglesias MT, Lozano JE. Extraction and characterization of sunflower pectin. J Food Eng. 2004;62:215–223. doi:10.1016/S0260-8774(03)00234-8

32. Zouambia Y, Ettoumi KY, Krea M, Moulai-Mostefa N. A new approach for pectin extraction: Electromagnetic induction heating. Arab J Chem. 2017;10:S480–S487. doi:10.1016/j.arabjc.2012.07.018

33. Rodsamran P, Sothornvit R. Microwave heating extraction of pectin from lime peel: Characterization and properties compared with the conventional heating method. Food Chem. 2019;278:364–372. doi:10.1016/j.foodchem.2018.11.067

34. Xu Y, Zhang L, Bailina Y, et al. Effects of ultrasound and/or heating on the extraction of pectin from grapefruit peel. J Food Eng. 2014;126:72–81. doi:10.1016/j.jfoodeng.2013.11.004

35. Abou-Elseoud WS, Hassan EA, Hassan ML. Extraction of pectin from sugar beet pulp by enzymatic and ultrasound-assisted treatments. Carbohydr Polym Technol Appl. 2021;2:100042. doi:10.1016/j.carpta.2021.100042

36. Pacheco MT, Villamiel M, Moreno R, Moreno FJ. Structural and rheological properties of pectins extracted from industrial sugar beet by-products. Molecules. 2019;24:392. doi:10.3390/molecules24020392

37. Méndez D, Fabra MJ, Gómez-Mascaraque LG, López-Rubio A, Martinez-Abad A. Modelling the extraction of pectin towards the valorisation of watermelon rind waste. Foods. 2021;10:738. doi:10.3390/foods10040738

38. Hassan ML, Berglund L, Abou Elseoud WS, Hassan EA, Oksman K. Effect of pectin extraction method on properties of cellulose nanofibers isolated from sugar beet pulp. Cellulose. 2021;28:10905–10920. doi:10.1007/s10570-021-04189-6

39. Khamsucharit P, Laohaphatanalert K, Gavinlertvatana P, Sriroth K, Sangseethong K. Characterization of pectin extracted from banana peels of different varieties. Food Sci Biotechnol. 2018;27:623–629. doi:10.1007/s10068-017-0284-2

40. Wongkaew M, Sommano SR, Tangpao T, Rachtanapun P, Jantanasakulwong K. Mango peel pectin by microwave-assisted extraction and its use as fat replacement in dried Chinese sausage. Foods. 2020;9:450. doi:10.3390/foods9040450

41. Díaz-Rojas E, Pacheco-Aguilar R, Lizardi J, Argüelles-Monal W, Valdez M, Rinaudo M, et al. Linseed pectin: Gelling properties and performance as an encapsulation matrix for shark liver oil. Food Hydrocoll. 2004;18:293–304. doi:10.1016/S0268-005X(03)00078-4

42. Yang X, Nisar T, Hou Y, Gou X, Sun L, Guo Y. Pomegranate peel pectin can be used as an effective emulsifier. Food Hydrocoll. 2018;85:30–38. doi:10.1016/j.foodhyd.2018.06.040

43. Sylvie A, Louise W. Quality assessment of Borassus aethiopum Mart fruit pulp pectin precipitated with various solvents. Afr J Food Sci. 2020;14:222–232. DOI: Not available

44. Yapo BM, Koffi KL. Extraction and characterization of highly gelling low methoxy pectin from cashew apple pomace. Foods. 2014;3:1–12. doi:10.3390/foods3010001

45. Yuliarti O, Matia-Merino L, Goh KT, Mawson J, Brennan C. Characterisation of gold kiwifruit pectin isolated by enzymatic treatment. Int J Food Sci Technol. 2012;47:633–639. doi:10.1111/j.1365-2621.2011.02878.x

46. Kazemi M, Khodaiyan F, Labbafi M, Hosseini SS. Ultrasonic and heating extraction of pistachio by-product pectin: Physicochemical, structural characterization and functional measurement. J Food Meas Charact. 2019;14:679–693. doi:10.1007/s11694-019-00327-7

47. Wathoni N, Shan CY, Shan WY, Rostinawati T, Indradi RB, Pratiwi R, et al. Characterization and antioxidant activity of pectin from Indonesian mangosteen (Garcinia mangostana L.) rind. Heliyon. 2019;5:e02299. doi:10.1016/j.heliyon.2019.e02299

48. Sabater C, Blanco-Doval A, Montilla A, Corzo N. Optimisation of an enzymatic method to obtain modified artichoke pectin and pectic oligosaccharides using artificial neural network tools: In silico and in vitro antioxidant assessment. Food Hydrocoll. 2021;110:106161. doi:10.1016/j.foodhyd.2020.106161

49. Sharma R, Ranawat MS, Sayra B, Bhandar A, Chouhan CS. Statistical screening of starch paste and guar gum on hardness and disintegration time of fast dissolving tablet. Int. J. Pham. Pharm. Sci. 2012;1012(4):85-9.

50. Canteri-Schemin MH, Fertonani HC, Waszczynskyj N, Wosiacki G. Extraction of pectin from apple pomace. Braz Arch Biol Technol. 2005;48:259–266. doi:10.1590/S1516-89132005000200013

51. Chan SY, Choo WS. Effect of extraction conditions on the yield and chemical properties of pectin from cocoa husks. Food Chem. 2013;141:3752–3758. doi:10.1016/j.foodchem.2013.06.097

52. Hanssen NMJ, Kraakman MJ, Flynn MC, Nagareddy PR, Schalkwijk CG, Murphy AJ. Postprandial glucose spikes, an important contributor to cardiovascular disease in diabetes? Front Cardiovasc Med. 2020;7:570553. doi:10.3389/fcvm.2020.570553

53. Alssema M, Ruijgrok C, Blaak EE, Egli L, Dussort P, Vinoy S, et al. Effects of alpha-glucosidase inhibiting drugs on acute postprandial glucose and insulin responses: A systematic review and meta-analysis. Nutr Diabetes. 2021;11:11. doi:10.1038/s41387-021-00142-2

54. Jones M, Gu X, Stebbins N, Crandall P, Ricke S, Lee S. Effects of soybean pectin on blood glucose and insulin responses in healthy men. FASEB J. 2015;29:596.16. DOI: Not available

55. Bianchi F, Larsen N, Tieghi TDM, Adorno MAT, Kot W, Saad SMI, et al. Modulation of gut microbiota from obese individuals by in vitro fermentation of citrus pectin in combination with Bifidobacterium longum BB-46. Appl Microbiol Biotechnol. 2018;102:8827–8840. doi:10.1007/s00253-018-9258-2

56. Martínez-Martínez E, López-Ándres N, Jurado-López R, Rousseau E, Bartolomé MV, Fernández-Celis A, et al. Galectin-3 participates in cardiovascular remodeling associated with obesity. Hypertension. 2015;66:961–969. doi:10.1161/HYPERTENSIONAHA.115.06032

57. Seropian IM, Cassaglia P, Miksztowicz V, González GE. Unraveling the role of galectin-3 in cardiac pathology and physiology. Front Physiol. 2023;14:1304735. doi:10.3389/fphys.2023.1304735

58. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357:1121–1135. doi:10.1056/NEJMra071667

59. Hu X, Zhang K, Xu C, Chen Z, Jiang H. Anti-inflammatory effect of sodium butyrate preconditioning during myocardial ischemia/reperfusion. Exp Ther Med. 2014;8:229–232. doi:10.3892/etm.2014.1707

60. Hu X, Fu W, Jiang H. HMGB1: A potential therapeutic target for myocardial ischemia and reperfusion injury. Int J Cardiol. 2012;155:489. doi:10.1016/j.ijcard.2011.12.020

61. Xue H, Zhao Z, Lin Z, Geng J, Guan Y, Song C, et al. Selective effects of ginseng pectins on galectin-3-mediated T cell activation and apoptosis. Carbohydr Polym. 2019;219:121–129. doi:10.1016/j.carbpol.2019.05.020

62. Sharma RB, Kumar A, Dixit A. A Modern Approach on Mouth Dissolving Drug Technology: Film-Based Oral Delivery. Journal of Drug Delivery & Therapeutics. 2025 Aug 1;15(8).

63. Picot-Allain MCN, Neergheen VS. Pectin: A multifaceted biopolymer in the management of cancer: A review. Heliyon. 2023;9:e22236. doi:10.1016/j.heliyon.2023.e22236

64. Niu H, Dou Z, Hou K, Wang W, Chen X, Chen X, et al. A critical review of RG-I pectin: Sources, extraction methods, structure, and applications. Crit Rev Food Sci Nutr. 2024;64:8911–8931. doi:10.1080/10408398.2023.2180324

65. Jin H, Li M, Tian F, Yu F, Zhao W. An overview of antitumour activity of polysaccharides. Molecules. 2022;27:8083. doi:10.3390/molecules27228083

66. Bai Y, Gilbert RG. Mechanistic understanding of the effects of pectin on in vivo starch digestion: A review. Nutrients. 2022;14:5107. doi:10.3390/nu14235107

67. Lou J, Zhang B, Zheng Y, Liu M, Qu Y. Hawthorn pectin plays a protective role in myocardial ischaemia by regulating intestinal flora and short chain fatty acids. Curr Res Food Sci. 2024;9:100863. doi:10.1016/j.crfs.2024.100863

68. Freitas CM, Coimbra JS, Souza VG, Sousa RC. Structure and applications of pectin in food, biomedical, and pharmaceutical industry: A review. Coatings. 2021;11(8):922. doi:10.3390/coatings11080922

69. Voragen AG, Coenen GJ, Verhoef RP, Schols HA. Pectin, a versatile polysaccharide present in plant cell walls. Struct Chem. 2009;20(2):263–275. doi:10.1007/s11224-009-9442-z

70. Srivastava P, Malviya R. Sources of pectin, extraction and its applications in pharmaceutical industry—An overview. Indian J Nat Prod Resour. 2011;2(1):10–18.

71. Sriamornsak P. Chemistry of pectin and its pharmaceutical uses: A review. Silpakorn Univ Int J. 2003;3(1–2):206–228.

72. Kaushik K, Sharma RB, Agarwal S. Natural polymers and their applications. Int J Pharm Sci Rev Res. 2016;37(2):30–36.

73. Fegade VC, Narkhede SB, Kumar R. Formulation and evaluation of paracetamol tablet to assess binding property of Limonia acidissima pectin. Trop J Pharm Life Sci. 2023;10(5):01–11.

74. Wang SY, Meng YJ, Li J, Liu JP, Liu ZQ, Li DQ. A novel and simple oral colon-specific drug delivery system based on the pectin/modified nano-carbon sphere nanocomposite gel films. Int J Biol Macromol. 2020;157:170–176. doi:10.1016/j.ijbiomac.2020.04.150

75. Jain V, Shukla N, Mahajan S. Polysaccharides in colon specific drug delivery. J Transl Sci. 2015;1:3–11.

76. Gómez B, Gullón B, Yáñez R, Schols H, Alonso JL. Prebiotic potential of pectins and pectic oligosaccharides derived from lemon peel wastes and sugar beet pulp: A comparative evaluation. J Funct Foods. 2016;20:108–121. doi:10.1016/j.jff.2015.10.029

77. Larsen N, Bussolo de Souza C, Krych L, Barbosa Cahú T, Wiese M, Kot W, et al. Potential of pectins to beneficially modulate the gut microbiota depends on their structural properties. Front Microbiol. 2019;10:223. doi:10.3389/fmicb.2019.00223

78. Slavin J. Fiber and prebiotics: Mechanisms and health benefits. Nutrients. 2013;5(4):1417–1435. doi:10.3390/nu5041417

79. Mudgil D, Barak S. Composition, properties and health benefits of indigestible carbohydrate polymers as dietary fiber: A review. Int J Biol Macromol. 2013;61:1–6. doi:10.1016/j.ijbiomac.2013.06.044

80. Roman-Benn A, Contador CA, Li MW, Lam HM, Ah-Hen K, Ulloa PE, et al. Pectin: An overview of sources, extraction and applications in food products, biomedical, pharmaceutical and environmental issues. Food Chem Adv. 2023;2:100192. doi:10.1016/j.focha.2023.100192

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2026-07-15
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How to Cite

1.
Harsh H, Tomer S, Sharma R. Pectin as a Value-Added Biopolymer from Fruit Processing Waste: Structural Features, Extraction Methods, and Health Applications. J. Drug Delivery Ther. [Internet]. 2026 Jul. 15 [cited 2026 Jul. 16];16(7):292-9. Available from: https://www.jddtonline.info/index.php/jddt/article/view/7894

How to Cite

1.
Harsh H, Tomer S, Sharma R. Pectin as a Value-Added Biopolymer from Fruit Processing Waste: Structural Features, Extraction Methods, and Health Applications. J. Drug Delivery Ther. [Internet]. 2026 Jul. 15 [cited 2026 Jul. 16];16(7):292-9. Available from: https://www.jddtonline.info/index.php/jddt/article/view/7894