Advanced Drug Delivery Approaches for Antidiabetic Agents: Strategies to Enhance Bioavailability, Efficacy, and Patient Compliance
Abstract
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion, insulin action, or both. The global burden of diabetes is increasing rapidly, posing significant challenges to healthcare systems worldwide. Although several antidiabetic agents are available, their clinical effectiveness is often limited by poor bioavailability, rapid degradation, frequent dosing requirements, and low patient adherence.
Advanced drug delivery systems have emerged as a promising strategy to overcome these limitations by improving pharmacokinetics, enhancing drug stability, and enabling controlled or targeted release. Various novel systems such as nanoparticles, lipid-based carriers, polymeric systems, transdermal systems, and glucose-responsive drug delivery systems have shown significant improvements in therapeutic outcomes.
This review provides a comprehensive discussion on advanced drug delivery approaches for antidiabetic agents, focusing on strategies to enhance bioavailability, therapeutic efficacy, and patient compliance, along with challenges and future perspectives in clinical translation.
Keywords: Antidiabetic delivery, Drug delivery, Bioavailability enhancement, Controlled release, Glucose-responsive, Patient compliance
Keywords:
Antidiabetic delivery, Drug delivery, Bioavailability enhancement, Controlled release, Glucose-responsive, Patient complianceDOI
https://doi.org/10.22270/jddt.v16i5.7739References
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