Development and In Vitro Evaluation of Gastroretentive Floating Matrix Tablets of Hydralazine
Abstract
The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing Hydralazine as a model drug by using various proportions of polymers such as Sodium CMC, Carbopol p934 and HPMC K4M. This was employed to enhance the bioavailability and therapeutic efficacy of the drug. The sustained release formulations of Hydralazine using hydrophobic and hydrophilic polymers were prepared by direct compression method. Optimization of formulation was done by studying effect of drug to polymer ratio on drug release. FT-IR studies indicated absence of any interaction between Hydralazine, polymer (Sodium CMC, Carbopol P 934 and HPMC K4M) and excipients. Nine formulations were prepared and formulation F2 possessed good floating property with total floating time between 8-12 hours. The tablets were also evaluated for its hardness, friability, and in-vitro evaluation test. All parameters complied with IP limits. Results of this study indicated that the combinations of hydrophilic polymers with hydrophobic polymers are suitable to optimize sustained release formulation of Hydralazine.
Keywords: Hydralazine, Sodium CMC, Carbopol P934 and HPMC K4M, Floating Tablets
Keywords:
Hydralazine, Sodium CMC,, Carbopol P 934 and HPMC K4M, Floating TabletsDOI
https://doi.org/10.22270/jddt.v16i4.7683References
1. Neha narang. An Updated Review On: Floating Drug Delivery System (FDDS).
2. Arora S, Ali A, Ahuja A, Khar RK, Baboota S. Floating drug delivery systems: A review. AAPS PharmSciTech 2005; 6(3): E372‐ E390. https://doi.org/10.1208/pt060347 PMid:16353995 PMCid:PMC2750381
3. Chien YW. Rate‐control drug delivery systems: controlled release vs. sustained release. Med Prog Techn 1989; 15: 21‐46.
4. Chien YW. Oral drug delivery and delivery system in novel drug delivery Systems, ed, 50, Marcel Dekker publication, New York, 1992. https://doi.org/10.1201/9780367805456
5. Patel GM. Floating drug delivery system: An innovative approach to prolong gastric retention. www.pharmainfo.net, 2007.
6. Juhi Dubey and Navneet Verma. Floating Drug Delivery System: A Review. IJPSR, 2013; Vol. 4(8): 2893-2899.
7.Chikhalikar SS and Wakade RB: Floating Drug Delivery System - An Approach To Oral Controlled Drug Delivery. International Journal of PharmTech Research 2012; 4(4) 1812-26.
8. Chandel A, Chauhan K, Parashar B, Kumar H and Arora S: Floating drug delivery systems: A better approach. International Current Pharmaceutical Journal 2012; 1(5): 110-18 https://doi.org/10.3329/icpj.v1i5.10283
9. Shah SH, Patel JK, Patel NV: Stomach specific floating drug delivery system: A review. International Journal of Pharmaceutical Technology and Research 2009; 1(3): 623-33.
10.Kharia AA, Hiremath SN, Singhai AK and Jain SK: Design and optimization of floating drug delivery system of acyclovir. Indian Journal of Pharmaceutical Sciences 2010; 72(5): 599-06. https://doi.org/10.4103/0250-474X.78527 PMid:21694992 PMCid:PMC3116305
11.Bhowmik D, Chiranjib B, Margret C, Jayakar B and Kumar KPS: Floating Drug Delivery System-A Review. Scholars Research Library 2009; 1(2): 199-18
Published
Abstract Display: 19 
PDF Downloads: 11 PDF Downloads: 3 How to Cite
Issue
Section
Copyright (c) 2026 Munija Pancheddula, U. Srilatha, Nemuri Mounika, Srujana Raparti
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.