Development and Evaluation of Repaglinide Solid Dispersion Tablets using Natural Superdisintegrants
Abstract
The present study was undertaken to enhance the dissolution characteristics of Repaglinide, a poorly water-soluble antidiabetic drug, by employing the solid dispersion technique combined with natural superdisintegrants. The λmax of Repaglinide in phosphate buffer pH 6.8 was found to be 243 nm. Fourier Transform Infrared (FTIR) spectroscopy was carried out for the pure drug and optimized formulations, confirming the absence of any significant drug–excipient interactions.
Solid dispersions were prepared using PEG 4000 as a hydrophilic carrier and further formulated into tablets incorporating natural superdisintegrants such as Ocimum mucilage and Gellan gum. Pre-compression evaluation of the solid dispersion blends indicated good to fair flow properties, with angle of repose below 26.20°, Carr’s index ranging from 11.08 to 18.40, and Hausner’s ratio less than 1.22.
Post-compression evaluation revealed that all tablet formulations complied with pharmacopeial limits for weight variation, hardness, friability, thickness, and drug content uniformity. In vitro dissolution studies conducted in phosphate buffer pH 6.8 demonstrated a significant enhancement in drug release from the solid dispersion tablets when compared among formulations. Among all batches, formulation F6 exhibited rapid disintegration and the highest drug release of 99.16% within 45 minutes.
The study concludes that the combined approach of solid dispersion and natural superdisintegrants effectively improves the dissolution performance of Repaglinide tablets. Natural superdisintegrants such as Ocimum mucilage and Gellan gum may serve as promising, economical, and biocompatible alternatives to synthetic disintegrants in solid oral dosage forms.
Keywords: Repaglinide, Solid dispersion tablets, Natural superdisintegrants, In vitro dissolution, Dissolution enhancement.
Keywords:
Repaglinide, Solid dispersion tablets, Natural superdisintegrants, In vitro dissolutionDOI
https://doi.org/10.22270/jddt.v16i4.7618References
1. Hoerter, D., and Dressman, J.B., Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract (review). Adv. Drug Delivery Rev., 1997;25-14. https://doi.org/10.1016/S0169-409X(96)00487-5
2. Sengodan guruswamy, V., and Mishra, D.N., Preparation and evaluation of solid dispersion of meloxicam with skimmed milk. The Pharmaceutic. Soc. Jap., 2006;126(2):93-97. https://doi.org/10.1248/yakushi.126.93 PMid:16462098
3. Van Drooge, D.J. et al. Characterization of the molecular distribution of drugs in glassy solid dispersions at the nano-meter scale, using differential scanning calorimetry and gravimetric water vapour sorption techniques. Int. J. Pharm,. 2006;310:220-229. https://doi.org/10.1016/j.ijpharm.2005.12.007 PMid:16427226
4. Hancock, B.C., and Zogra, G., Characteristics and significance of the amorphous state in pharmaceutical systems (review). J. Pharm. Sci., 1997;86:1-12. https://doi.org/10.1021/js9601896 PMid:9002452
5. Sekiguchi, K., and Obi, N., Studies on absorption of eutectic mixtures. I. A comparison of the behavior of eutectic mixtures of sulphathiazole and that of ordinary sulphathiazole in man. Chem. Pharm. Bull., 1961;9:866-872. https://doi.org/10.1248/cpb.9.866
6. Goldberg, A.H., Gibaldi, M., and Kanig, J.L., Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures II ± experimental evaluation of a eutectic mixture: urea±acetaminophen system. J. Pharm. Sci., 1966;55:482-487. https://doi.org/10.1002/jps.2600550507
7. Goldberg, A.H., Gibaldi, M., and Kanig, J.L., Increasing dissolution rates andgastrointestinal absorption of drugs via solidsolutions and eutectic mixtures I theoretical considerations and discussion of the literature. J. Pharm. Sci., 1965;54:1145-1148. https://doi.org/10.1002/jps.2600540810 PMid:5882218
8. 1. Sameer Singh, Raviraj Singh Baghe and Lalit Yadav. A review on solid dispersion. Int. J. of Pharm. & Life Sci. (IJPLS), 2011;2(9):1078-1095.
9. Noyes, A.A., and Whitney W.R., The rate of solution of solid substances in their own solutions, J. Am. Chem. Soc., 1897;19:930-934. https://doi.org/10.1021/ja02086a003
10. Loftsson, T., and Brewster, M.E., Pharmaceutical application of cyclodextrins. Drug solubilisation and stabilization (review). J. Pharm. Sci., 1996;85:1010-1025. https://doi.org/10.1021/js950534b PMid:8897265
11. Goldberg, A.H., Gibaldi, M., and Kanig, J.L., Increasing dissolution rates andgastrointestinal absorption of drugs via solidsolutions and eutectic mixtures I theoretical considerations and discussion of the literature. J. Pharm. Sci., 1965;54:1145-1148 https://doi.org/10.1002/jps.2600540810 PMid:5882218
12. Kreuter, J., Kreuter, J., and Herzfeldt, C.D., Grundlagen der Arznei-formenlehre Galenik, 2, Springer, Frankfurt am Main. 1999;262-274.
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