Green Polymers for Human Welfare: Exploring Plant-Derived Natural Gums as Safe Polysaccharides in Sustainable Drug Delivery Systems

Authors

Abstract

Natural gums derived from plants are gaining traction as valuable biopolymers in the creation of safe, sustainable, and effective pharmaceutical products. These polysaccharides such as guar gum, xanthan gum, locust bean gum, and gum karaya possess favorable physicochemical attributes, including high viscosity, swelling properties, and the ability to form films, which allow them to function as matrix formers, binders, and release retardants in both oral and innovative drug delivery systems. In contrast to synthetic polymers, natural gums demonstrate biocompatibility, biodegradability, renewability, and cost efficiency. This review focuses on the structural features, formulation benefits, and limitations of plant-based gums, highlighting their utility in both traditional and advanced drug delivery methods. It also examines strategies for chemical modifications, smart polymer characteristics for targeted release, and recent studies that underscore their significance in sustained and targeted drug delivery. The paper concludes by discussing future research avenues and the promise of these eco-friendly polymers to enhance human well-being and drive sustainable innovations in pharmaceuticals.

Keywords: Natural gums, Green polymers, Biopolymers, Drug delivery systems, Controlled release, Pharmaceutical applications

Keywords:

Natural polymer, Drug delivery system, sustained release systems, Biopolymers, Green polymer

DOI

https://doi.org/10.22270/jddt.v16i3.7602

Author Biographies

Tusara Kanta Behera , Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Santosh Kumar Dash , Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Ram Shankar Naik , Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Roshan Kumar Pradhan , Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Pujarani Kalsai , Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Reshma Ranbir , Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Kshireswari Sahu , Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Priyanka Sharma , Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, 768029

References

1. Kumar S, Gupta SK. Natural polymers, gums and mucilages as excipients in drug delivery. Polim Med. 2012;42(3-4):191-197.

2. Thakur VK, Thakur MK. Processing and characterization of natural cellulose fibers/thermoset polymer composites. Carbohydr Polym. 2014;109:102-117. https://doi.org/10.1016/j.carbpol.2014.03.039 PMid:24815407

3. Prajapati VD et al. Pharmaceutical applications of various natural gums, mucilages and their modified forms. Carbohydr Polym. 2013;92(2):1685-1699. https://doi.org/10.1016/j.carbpol.2012.11.021 PMid:23399207

4. Patel VR, Amiji MM. Pharmaceutical excipients derived from natural sources. Pharm Technol. 2015;39:42-50.

5. Singh B, Sharma N. Modification of natural gums: methods, properties and applications. Carbohydr Polym. 2017;177:37-48. https://doi.org/10.1016/j.carbpol.2017.08.060 PMid:28927630

6. Sinha VR, Kumria R. Polysaccharides in colon-specific drug delivery. Int J Pharm. 2001;224(1-2):19-38.https://doi.org/10.1016/S0378-5173(01)00720-7 PMid:11472812

7. Reddy KR et al. Once-daily sustained-release matrix tablets of nicorandil. AAPS PharmSciTech. 2003;4(4):E61. https://doi.org/10.1208/pt040461 PMid:15198556 PMCid:PMC2750654

8. Rowe RC et al. Handbook of Pharmaceutical Excipients. 6th ed. 2009.

9. Kulkarni GT et al. Binding properties of mucilages. Indian J Pharm Sci. 2002;64(5):482-486.

10. Nokhodchi A et al. Oral controlled-release matrix tablets. Biomed Res Int. 2014;2014:1-16.

11. Andrews GP et al. Mucoadhesive polymeric platforms. Eur J Pharm Biopharm. 2009;71(3):505-518. https://doi.org/10.1016/j.ejpb.2008.09.004 PMid:18835441

12. Builders PF, Anwunobi PA. Mucilage in drug delivery. J Pharm Allied Sci. 2012;9(1):1-17.

13. Colombo P et al. Swelling and release mechanisms. J Control Release. 1996;39(2-3):231-237. https://doi.org/10.1016/0168-3659(95)00158-1

14. Smart JD. Mechanisms of mucoadhesion. Adv Drug Deliv Rev. 2005;57(11):1556-1568. https://doi.org/10.1016/j.addr.2005.07.001 PMid:16198441

15. Deshpande AA et al. Gastric retention system. Pharm Res. 1997;14(6):815-819. https://doi.org/10.1023/A:1012171010492 PMid:9210203

16. Chourasia MK, Jain SK. Colon targeted systems. J Pharm Pharm Sci. 2003;6(1):33-66.

17. George M, Abraham TE. Alginate & chitosan. J Control Release. 2006;114(1):1-14. https://doi.org/10.1016/j.jconrel.2006.04.017 PMid:16828914

18. McClements DJ. Encapsulation systems. Adv Colloid Interface Sci. 2015;219:27-53. https://doi.org/10.1016/j.cis.2015.02.002 PMid:25747522

19. Koyyada A, Orsu P. Natural gum polysaccharides. J Drug Deliv Sci Technol. 2021;63:102431. https://doi.org/10.1016/j.jddst.2021.102431

20. Badwaik HR et al. Carboxymethylation of polysaccharides. Int J Biol Macromol. 2015;79:939-950. https://doi.org/10.1016/j.ijbiomac.2015.06.017 PMid:26092169

21. Peppas NA, Khare AR. Hydrogels. Adv Drug Deliv Rev. 1993;11(1-2):1-35. https://doi.org/10.1016/0169-409X(93)90025-Y

22. Pushpamalar J et al. Biodegradable polysaccharides. ChemPlusChem. 2016;81(6):504-514. https://doi.org/10.1002/cplu.201600112 PMid:31968918

23. Kruk K, Winnicka K. Alginate platforms. Mar Drugs. 2023;21(1):11. https://doi.org/10.3390/md21010011 PMid:36662184 PMCid:PMC9861938

24. Cirillo G et al. Alginate-graphene hydrogels. Molecules. 2021;26(5):1355. https://doi.org/10.3390/molecules26051355 PMid:33802608 PMCid:PMC7961670

25. Madineh H et al. Stimuli-responsive systems. Int J Biol Macromol. 2025;142648. https://doi.org/10.1016/j.ijbiomac.2025.142648 PMid:40174846

26. Munday DL, Cox PJ. Xanthan & karaya matrices. Int J Pharm. 2000;203(1-2):179-192. https://doi.org/10.1016/S0378-5173(00)00471-3 PMid:11000537

27. Vegad U et al. pH-responsive hydrogels. Front Bioeng Biotechnol. 2023;11:1270364. https://doi.org/10.3389/fbioe.2023.1270364 PMid:37781530 PMCid:PMC10540072

28. Sinha VR, Kumria R. Microbially triggered delivery. Eur J Pharm Sci. 2003;18(1):3-18. https://doi.org/10.1016/S0928-0987(02)00242-7 PMid:12554075

29. Rajamma AJ et al. Gastroretentive system. DARU J Pharm Sci. 2012;20:58. https://doi.org/10.1186/2008-2231-20-58 PMid:23352292 PMCid:PMC3556007

30. Varshosaz J et al. Metoprolol tablets. Drug Dev Ind Pharm. 2006;32(4):461-467. https://doi.org/10.1080/03639040500405866

31. Üner M, Altinkurt T. Honey locust gum. Il Farmaco. 2004;59(7):567-573. https://doi.org/10.1016/j.farmac.2004.04.005 PMid:15231434

32. Sivakumar T, Gopi D. Tramadol SR tablets. Drug Dev Ind Pharm. 2006;32(4):461-467. https://doi.org/10.1080/03639040500405866

33. Gande S, Rao YM. Floating baclofen tablets. DARU J Pharm Sci. 2011;19(3):202-209. https://doi.org/10.1186/1560-8115-19-202

34. Hamman HH et al. Natural gums as excipients. Curr Pharm Des. 2015;21(33):4835-4848. https://doi.org/10.2174/1381612821666150820100524 PMid:26290212

35. Dash SK et al. Pulsatile delivery system. Int J Pharm Sci Res. 2020;11(7):3229-3242. https://doi.org/10.13040/IJPSR.0975-8232.11(7).3229-42

36. Malviya R et al. Gum modification. Recent Pat Drug Deliv Formul. 2020;14(3):214-222. https://doi.org/10.2174/1872211314666201204160641 PMid:33280600

Published

2026-03-15
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How to Cite

1.
Behera TK, Dash SK, Naik RS, Pradhan RK, Kalsai P, Ranbir R, et al. Green Polymers for Human Welfare: Exploring Plant-Derived Natural Gums as Safe Polysaccharides in Sustainable Drug Delivery Systems. J. Drug Delivery Ther. [Internet]. 2026 Mar. 15 [cited 2026 Apr. 18];16(3):146-51. Available from: https://www.jddtonline.info/index.php/jddt/article/view/7602

How to Cite

1.
Behera TK, Dash SK, Naik RS, Pradhan RK, Kalsai P, Ranbir R, et al. Green Polymers for Human Welfare: Exploring Plant-Derived Natural Gums as Safe Polysaccharides in Sustainable Drug Delivery Systems. J. Drug Delivery Ther. [Internet]. 2026 Mar. 15 [cited 2026 Apr. 18];16(3):146-51. Available from: https://www.jddtonline.info/index.php/jddt/article/view/7602

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