Topical Emulgels: A Hybrid System for Improved Dermal and Transdermal Drug Delivery
Abstract
The goal of this study was to formulate an emulgel formulation for topical administration that would prevent hepatic first-pass metabolism, increase emulsion stability, lower dosage requirements, and increase residence time. An emulgel is a hybrid dosage form that combines the properties of both emulsions and gels, which are particularly significant for the delivery of hydrophobic substances; it enhances drug penetration through the epidermal barrier and promotes effective skin diffusion (especially for medications with low water solubility). This article looks at the advantages, choice of components, preparation methods, development, and characterization of emulgel in drug delivery, all of which are based on the latest research. The pH, viscosity, particle size, zeta potential, drug content, stability study, skin irritation test, and other properties of the prepared formulation are evaluated.
Keywords: Emulgel, hybrid dosage form, hydrophobic substances, future aspect
Keywords:
Emulgel, Hybrid dosage form, Hydrophobic substanceDOI
https://doi.org/10.22270/jddt.v16i3.7591References
1. Nagaraja S, Basavarajappa GM, Attimarad M, Pund S. Topical nanoemulgel for the treatment of skin cancer: Proof-of-technology. Pharmaceutics. 2021 Jun 18; 13(6):902. https://doi.org/10.3390/pharmaceutics13060902 PMid:34207014 PMCid:PMC8234434
2. de Golian E, Kwong BY, Swetter SM, Pugliese SB. Cutaneous complications of targeted melanoma therapy. Current treatment options in oncology. 2016 Nov; 17(11):57. https://doi.org/10.1007/s11864-016-0434-0 PMid:27645330
3. Sabu KR, Basarkar GD. Formulation, development and in-vitro evaluation of terbinafine hydrochloride emulgel for topical fungal infection. Int J Pharm Sci Rev Res. 2013; 21(2):13.
4. Jadhav KR. Design of novel nanogel formulation of naproxen sodium for enhanced anti-inflammatory effect. Asian Journal of Pharmaceutics (AJP). 2022 Jun 15; 16(2).
5. Gaber DA, Alsubaiyel AM, Alabdulrahim AK, Alharbi HZ, Aldubaikhy RM, Alharbi RS, Albishr WK, Mohamed HA. Nano-emulsion based gel for topical delivery of an anti-inflammatory drug: in vitro and in vivo evaluation. Drug design, development and therapy. 2023 Dec 31;1435-51. https://doi.org/10.2147/DDDT.S407475 PMid:37216175 PMCid:PMC10198277
6. Lilhare KT, Borkar SS, Baheti JR. Recent Update on Topical Drug Delivery Systems: Emulgel. Asian Journal of Pharmaceutical Research and Development. 2023 Aug 13; 11(4):133-8. https://doi.org/10.22270/ajprd.v11i4.1299
7. Talat M, Zaman M, Khan R, Jamshaid M, Akhtar M, Mirza AZ. Emulgel: An effective drug delivery system. Drug Development and Industrial Pharmacy. 2021 Aug 3; 47(8):1193-9. https://doi.org/10.1080/03639045.2021.1993889 PMid:34647512
8. Priya S, Shridhar P, Shekhara K, Shenthar S, Kudva SK. Tolnaftate-loaded ethosomal gel for topical delivery: Formulation and in vitro evaluation. Journal of Health and Allied Sciences NU. 2025 Jan; 15(01):026-31. https://doi.org/10.1055/s-0044-1787293
9. Dhawas V, Dhabarde D, Patil S. Emulgel: A comprehensive review for novel topical drug delivery system. International journal of recent scientific research. 2020 Feb; 11(4):38134-8. http://dx.doi.org/10.24327/ijrsr.2020.1104.5247
10. Algahtani MS, Ahmad MZ, Ahmad J. Nanoemulgel for improved topical delivery of retinyl palmitate: formulation design and stability evaluation. Nanomaterials. 2020 Apr 28; 10(5):848. https://doi.org/10.3390/nano10050848 PMid:32353979 PMCid:PMC7711631
11. Sainy J, Atneriya U, MAHESHWARI R. Development of an Aloe vera-based Emulgel for the Topical Delivery of Desoximetasone. Turkish journal of pharmaceutical sciences. 2021 Sep 1; 18(4):465. https://doi.org/10.4274/tjps.galenos.2020.33239 PMid:34496553 PMCid:PMC8430412
12. Kumar D, Singh J, Antil M, Kumar V. Emulgel-novel topical drug delivery system-a comprehensive review. Int J Pharm Sci Res. 2016; 7(12):4733-4742. https://doi.org/10.13040/IJPSR.0975-8232
13. Awlqadr FH, Majeed KR, Altemimi AB, Hassan AM, Qadir SA, Saeed MN, Faraj AM, Salih TH, Abd Al‐Manhel AJ, Najm MA, Tsakali E. Nanotechnology-based herbal medicine: Preparation, synthesis, and applications in food and medicine. Journal of Agriculture and Food Research. 2025 Jan 31:101661. https://doi.org/10.1016/j.jafr.2025.101661
14. Patel BM, Kuchekar AB, Pawar SR. Emulgel approach to formulation development: a review. Biosciences Biotechnology Research Asia. 2021 Oct 27; 18(3):459-65. https://doi.org/10.13005/bbra/2931
15. Malavi S, Kumbhar P, Manjappa A, Chopade S, Patil O, Kataria U, Dwivedi J, Disouza J. Topical Emulgel: Basic Considerations in Development and Advanced Research. Indian Journal of Pharmaceutical Sciences. 2022 Sep 1; 84(5). https://doi.org/10.36468/pharmaceutical-sciences.1005
16. Bhoi AU, Pise SD, Bhoi UA. An overview: Emulgel as a novel topical drug delivery. Indian J Novel Drug Deliv. 2023; 15(2):52-58.
17. Dev A, Chodankar R, Shelke O. Emulgels: A novel topical drug delivery system. Pharm. Biol. Eval. 2015 Aug 26; 2(4):64-75.
18. Singh BP, Kumar B, Jain SK, Shafaat K. Development and characterization of a nanoemulsion gel formulation for transdermal delivery of carvedilol. Int J Drug Dev Res. 2012; 4(1):151-61.
19. Bachhav YG, Patravale VB. Microemulsion-based vaginal gel of clotrimazole: formulation, in vitro evaluation, and stability studies. Aaps Pharmscitech. 2009 Jun; 10(2):476-81. https://doi.org/10.1208/s12249-009-9233-2 PMid:19381825 PMCid:PMC2690796
20. Khamkat P, Singh S, Chatterjee B, Banerjee S, Maiti S, Mandal S, Chowdhury B, Hasan MM. Advancement and future window of emulgel for intensifying transdermal delivery in the treatment of skin diseases. J Young Pharm. 2025; 17(4):816-823. https://doi.org/10.5530/jyp.20250008
21. Khullar R, Kumar D, Seth N, Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi pharmaceutical journal. 2012 Jan 1; 20(1):63-7. https://doi.org/10.1016/j.jsps.2011.08.001 PMid:23960777 PMCid:PMC3745000
22. Ganju E, Deshmukh S, Gupta BK. Emulgel towards novel formulation development: a comprehensive review. International Journal of Medical & Pharmaceutical Sciences. 2024 Jan; 14(1):1. https://doi.org/10.31782/IJMPS.2024.14101
23. Bisht B, Dutta D, Bisht M. Emulgels: A promising topical drug delivery system. Afr J Biomed Res. 2024; 27(4S):14439-14447. https://doi.org/10.53555/AJBR.v27i4S.7280
24. Charyulu NR, Joshi P, Dubey A, Shetty A. Emulgel: A boon for enhanced topical drug delivery. Journal of Young Pharmacists. 2021; 13(1):76. https://doi.org/10.5530/jyp.2021.13.17
25. Donthi MR, Munnangi SR, Krishna KV, Saha RN, Singhvi G, Dubey SK. Nanoemulgel: a novel nano carrier as a tool for topical drug delivery. Pharmaceutics. 2023 Jan 3; 15(1):164. https://doi.org/10.3390/pharmaceutics15010164 PMid:36678794 PMCid:PMC9863395
26. Singh S, Singh I. Evolving implementation of emulgel as a topical drug delivery system: A systematic review. Current Research in Pharmaceutical Sciences. 2022 Nov 23:121-31. https://doi.org/10.24092/CRPS.2022.120301
27. Devi S, Kumari B. Emugel for topical drug delivery: A novel approach. GSC Biol. Pharm. Sci.. 2020; 11:104-14. https://doi.org/10.30574/gscbps.2020.11.3.0165
28. Sreevidya VS. An overview on emulgel. International Journal of Pharmaceutical and Phytopharmacological Research. 2019; 9(1):92-7.
29. Supriya U, Seema CB, Preeti K. Emulgel: A Boon for Dermatological Diseases. International Journal of Pharmaceutical Research & Allied Sciences. 2014 Oct 1; 3(4).
30. Milutinov J, Krstonošić V, Ćirin D, Pavlović N. Emulgels: promising carrier systems for food ingredients and drugs. Polymers. 2023 May 13; 15(10):2302. https://doi.org/10.3390/polym15102302 PMid:37242878 PMCid:PMC10223308
31. Bhaskar R, Ola M, Suroshe Y, Gaware S.. Emulgel: An emerging trend in topical drug delivery system. International Journal of Pharmaceutical Research and Applications. 2022: 7(4):447-454. doi:10.35629/7781-0704447454
32. Kar M, Chourasiya Y, Maheshwari R, Tekade R. K. Current developments in excipient science: implication of quantitative selection of each excipient in product development. In Basic fundamentals of drug delivery. 2019: (pp. 29-83). Academic Press https://doi.org/10.1016/B978-0-12-817909-3.00002-9
33. Schmitt PD, Fischer AF, Silva RM, Cruz AB. Compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant content. Brazilian Journal of Pharmaceutical Sciences. 2022 Sep 2; 58:e191088. https://doi.org/10.1590/s2175-97902022e191088
34. Gupta S, Gupta J, Anand A, Ojha S. Review on nanogel/emulgel formulations of traditional medicines. Biological Sciences. 2022 Jul 29; 2(3):269-78. https://doi.org/10.55006/biolsciences.2022.2304
35. Chellapa P, Mohamed AT, Keleb EI, Elmahgoubi A, Eid AM, Issa YS, Elmarzugi NA. Nanoemulsion and nanoemulgel as a topical formulation. IOSR J Pharm. 2015 Oct; 5(10):43-7.
36. Srivastava H, Vishwakarma A, Kumar R, Yadav S. A review on nano-emulgel as a novel carrier for topical drug delivery system. Int J Pharm Sci Rev Res. 2024; 84(2):62-69. https://doi.org/10.47583/ijpsrr.2024.v84i02.009
37. Begum SG, Chetty CM, Pavithra B, Akhila B, Gayathri C, Ruksar S, Sravani T, Voleti VK. A review on emulgels-a novel approach for topical drug delivery. Asian Journal of Pharmaceutical Research and Development. 2019 Apr 15; 7(2):70-7. https://doi.org/10.22270/ajprd.v7i2.477
38. Jadhav P, Shaikh A, Buchade R. Emulgel review - A novel topical drug delivery system. International Journal of Pharmaceutical Sciences Review and Research. 2024; 84(5):115-121. https://doi.org/10.47583/ijpsrr.2024.v84i05.020
39. Singla V, Saini S, Joshi B, Rana AC. Emulgel: A new platform for topical drug delivery. International Journal of Pharma and Bio Sciences. 2012; 3(1):485-98.
40. Vanpariya F, Shiroya M, Malaviya M. Emulgel: A review. International Journal of Science and Research. 2021:10(3), 847-852. https://doi.org/10.21275/SR21311095015
41. Yadav SK, Mishra MK, Tiwari A, Shukla A. Emulgel: A new approach for enhanced topical drug delivery. Int J Curr Pharm Res. 2016 Dec; 9(1):15-9. https://doi.org/10.22159/ijcpr.2017v9i1.16628
42. Denei AA, Reddy DM. A Review on Formulation and Evaluation of Emulgel. International Journal of All Research Education and Scientific Methods. 2022; 10(2):1378-86.
43. Hardenia A, Jayronia S, Jain S. Emulgel: An emergent tool in topical drug delivery. International journal of pharmaceutical sciences and research. 2014 May 1; 5(5):1653.
44. Shah RS. Formulation and evaluation of Turmeric emulgel. Asian Journal of Pharmacy and Technology. 2021; 11(3):213-9. https://doi.org/10.52711/2231-5713.2021.00035
45. Sheshala R, Anuar NK, Abu Samah NH, Wong TW. In vitro drug dissolution/permeation testing of nanocarriers for skin application: A comprehensive review. AAPS PharmSciTech. 2019 Apr 15; 20(5):164. https://doi.org/10.1208/s12249-019-1362-7 PMid:30993407
46. Kanfer I, Rath S, Purazi P, Mudyahoto NA. In vitro release testing of semi-solid dosage forms. Dissolut. Technol. 2017 Aug 1; 24(3):52-60. https://doi.org/10.14227/DT240317P52
47. Patel BM, Kuchekar AB, Pawar SR. Emulgel approach to formulation development: a review. Biosciences Biotechnology Research Asia. 2021 Oct 27; 18(3):459-65. https://doi.org/10.13005/bbra/2931
48. Ashara K, Soniwala M, Shah K. Emulgel: A novel drug delivery system. Journal of Pakistan Association of Dermatologists. 2016; 26(3):244-9.
49. Jones DS, Woolfson AD, Brown AF. Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers. International journal of pharmaceutics. 1997 May 26; 151(2):223-33. https://doi.org/10.1016/S0378-5173(97)04904-1
50. Gaikwad N, Aher R, Bagul M, Sharma Y, Sonawane D, Patil D. A comprehensive review on emulgel as a topical drug delivery system. International Journal in Pharmaceutical Sciences. 2024; 2(5):1398-405. 10.5281/zenodo.11317649
51. Trant E. Harnessing innovation: Exploring the applications and advancements of emulgel in pharmaceutical formulations. Der Pharmacia Lettre. 2023; 15(11): 19-21. doi: 10.37532/dpl.2023.15.19.
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