Immunohistochemical Evaluation of APAF-1 and E-Cadherin Expression in Placentas of Smoking Women with Premature Rupture of Membranes
Abstract
Objective: This study aimed to evaluate the immunohistochemical expression of APAF-1 and E-cadherin in placental tissues of smoking women with premature rupture of membranes (PROM).
Materials and Methods: Placental samples obtained from smoking and non-smoking women diagnosed with PROM and from healthy controls were examined immunohistochemically for APAF-1 and E-cadherin expression.
Results: Increased APAF-1 expression and decreased E-cadherin expression were observed in placentas of smoking women with PROM compared to controls.
Conclusion: Smoking may contribute to PROM by enhancing apoptotic activity and disrupting placental cell–cell adhesion.
Keywords: placenta, apaf-1, prom, smoking
Keywords:
placenta, apaf-1, prom, smokingDOI
https://doi.org/10.22270/jddt.v16i2.7565References
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Copyright (c) 2026 Enis Duran , Murat Akkuş , Senem Çetin Duran, Fırat Aşır , Nilifer Dönmezdil
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