Therapeutic Evaluation of Super Joints Tablets (SJT): A Multi-Herbal Nutraceutical Formulation for Managing Joint Degeneration and Inflammation
Abstract
Super Joints Tablets (SJT), developed by ManahVedaTM is a multi-nutrient and multi-herbal nutraceutical formulation designed to support joint integrity, reduce inflammatory responses, and enhance overall musculoskeletal function. It contains Glucosamine Hydrochloride, Withania somnifera (Ashwagandha) root extract, Trigonella foenum-graecum seed extract (standardized to saponins), Boswellia serrata extract (standardized to boswellic acid), Rosa canina (Rosehip) extract, Curcuma longa extract (standardized to curcumin), Alpinia galanga (Rasna) extract, and Piper nigrum extract standardized to piperine. These ingredients collectively target inflammatory pathways, oxidative damage, cartilage degeneration, and neuromuscular stress-primary contributors to osteoarthritis and chronic joint disorders. Glucosamine plays a structural role in cartilage formation, while Boswellia, Curcumin, and Rosehip exhibit potent anti-inflammatory and antioxidant effects. Ashwagandha contributes adaptogenic and stress-modulating effects, Fenugreek adds metabolic and analgesic support, and Rasna offers classical musculoskeletal benefits rooted in Ayurvedic medicine. Piperine enhances the bioavailability of co-administered phytochemicals, especially curcumin. This article evaluates the therapeutic potential of the formulation using available scientific literature, establishing a mechanistic rationale for its synergistic activity. The multi-target benefits of Super Joints Tablet position it as a promising adjunct approach for individuals experiencing osteoarthritis, inflammatory joint conditions, age-related musculoskeletal decline, and mobility limitations. The scientific foundation of the ingredients indicates that the formulation may reduce pain, improve joint lubrication, enhance flexibility, and slow degenerative processes. Further clinical investigation is warranted to validate long-term outcomes, optimal dosing strategies, and comparative efficacy with conventional therapies. Overall, Super Joints Tablet demonstrates potential as a holistic nutraceutical intervention for joint support, inflammation control, and improved quality of life.
Keywords: Joint Integrity Support; Anti-Inflammatory Nutraceuticals; Cartilage Protection; Ayurvedic Multi-Herbal Formulation; Osteoarthritis Management
Keywords:
Joint Integrity Support, Anti-Inflammatory Nutraceuticals, Cartilage Protection, Ayurvedic Multi-Herbal Formulation, Osteoarthritis ManagementDOI
https://doi.org/10.22270/jddt.v15i12.7509References
1. Arden N, Nevitt MC. Osteoarthritis: epidemiology. Best Pract Res Clin Rheumatol. 2006;20(1):3-25. https://doi.org/10.1016/j.berh.2005.09.007 PMid:16483904
2. Bjordal JM, Klovning A, Ljunggren AE, Slørdal L. Short-term efficacy of NSAIDs in osteoarthritis. BMJ. 2004;329:1317-22. https://doi.org/10.1136/bmj.38273.626655.63 PMid:15561731 PMCid:PMC534841
3. Shahidi F, Ambigaipalan P. Nutraceuticals and functional foods. J Food Bioact. 2015;1:221-35.
4. Martel-Pelletier J, et al. Osteoarthritis: pathophysiology. Nat Rev Rheumatol. 2016;12:412-20. https://doi.org/10.1038/nrrheum.2016.65 PMid:27192932 PMCid:PMC4938009
5. Hunter DJ, Bierma-Zeinstra S. Osteoarthritis management. Lancet. 2019;393:1745-59. https://doi.org/10.1016/S0140-6736(19)30417-9 PMid:31034380
6. Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis review. Lancet. 2011;377:2115-26. https://doi.org/10.1016/S0140-6736(11)60243-2 PMid:21684382
7. Felson DT. Clinical aspects of osteoarthritis. N Engl J Med. 2006;354:841-8. https://doi.org/10.1056/NEJMcp051726 PMid:16495396
8. Loeser RF. Ageing and OA. Nat Rev Rheumatol. 2010;6:412-20.
9. Litwic A, Edwards MH, Dennison EM, Cooper C. Epidemiology of OA. Br Med Bull. 2013;105:185-99. https://doi.org/10.1093/bmb/lds038 PMid:23337796 PMCid:PMC3690438
10. Hunter DJ. OA causes and management. Clin Geriatr Med. 2010;26:355-69.
11. Goldring MB, Marcu KB. Cartilage homeostasis. Arthritis Res Ther. 2009;11:224. https://doi.org/10.1186/ar2592 PMid:19519926 PMCid:PMC2714092
12. Malemud CJ. Matrix metalloproteinases in OA. Front Biosci. 2006;11:165-7. https://doi.org/10.2741/1915 PMid:16368548
13. Kapoor M, et al. Role of cytokines in OA. Nat Rev Rheumatol. 2011;7:33-42. https://doi.org/10.1038/nrrheum.2010.196 PMid:21119608
14. Abramson SB. Inflammation and OA. Arthritis Rheum. 2008;58:105-9.
15. Berenbaum F. Inflammation as a therapeutic target. Osteoarthritis Cartilage. 2013;21:1141-9. https://doi.org/10.1016/j.joca.2012.11.012 PMid:23194896
16. Henrotin Y, Kurz B, Aigner T. Nutraceuticals in OA. Osteoarthritis Cartilage. 2005;13:853-65. https://doi.org/10.1016/j.joca.2005.04.002 PMid:15936958
17. Gupta RC, Lall R, Srivastava A, Sinha A. Nutraceuticals in joint health. J Food Nutr Disord. 2013;2:1-8.
18. Gruenwald J. Joint-support nutraceuticals. Phytomedicine. 2007;14:67-75.
19. Wang Y, et al. Natural products for joint inflammation. Molecules. 2018;23:123.
20. Vangsness CT, et al. Cartilage repair strategies. Sports Health. 2009;1:46-54.
21. Henrotin Y, Kurz B, Aigner T. Oxygen and reactive oxygen species in cartilage degradation. Osteoarthritis Cartilage. 2005;13(8):643-54. https://doi.org/10.1016/j.joca.2005.04.002 PMid:15936958
22. Christensen R, Lorenzen JK, Laursen T, et al. Rosehip powder reduces pain in osteoarthritis. Osteoarthritis Cartilage. 2008.
23. Basch E, Ulbricht C, Kuo G, et al. Therapeutic applications of fenugreek. Altern Med Rev. 2003;8(1):20-7.
24. Chandrasekhar K, Kapoor J, Anishetty S. Ashwagandha for stress and anxiety. Indian J Psychol Med. 2012;34(3):255-62. https://doi.org/10.4103/0253-7176.106022 PMid:23439798 PMCid:PMC3573577
25. Somani R, Singhai A. Analgesic and anti-inflammatory effects of Alpinia galanga. Int J Pharm Sci Rev Res. 2015;31(1):120-4.
26. Anandacoomarasamy A, March L. Nutraceuticals in osteoarthritis. Arthritis Res Ther. 2010.
27. Henrotin Y, et al. Glucosamine and chondroitin sulfate in OA. Osteoarthritis Cartilage. 2012.
28. Towheed T, et al. Glucosamine therapy for OA. BMJ. 2005.
29. Chandrasekhar K, et al. Ashwagandha trial. Indian J Psychol Med. 2012;34(3):255-62. https://doi.org/10.4103/0253-7176.106022 PMid:23439798 PMCid:PMC3573577
30. Salve J, et al. Adaptogenic effects of Withania somnifera. Ayurveda Res Pract. 2019.
31. Basch E, et al. Fenugreek applications. Altern Med Rev. 2003;8(1):20-7.
32. Neelakantan N, et al. Fenugreek and metabolic regulation. Nutr J. 2014.
33. Sengupta K, et al. Boswellia serrata for knee OA. Arthritis Res Ther. 2008;10(4):R85.
34. Ammon HP. Boswellic acids review. Planta Med. 2006;72:1100-16. https://doi.org/10.1055/s-2006-947227 PMid:17024588
35. Winther K, et al. Rosehip powder for OA. Scand J Rheumatol. 2005;34(4):302-8. https://doi.org/10.1080/03009740510018624 PMid:16195164
36. Rein E, et al. Rosa canina evidence. Phytother Res. 2008.
37. Aggarwal BB, Harikumar KB. Curcumin and inflammation. Int J Biochem Cell Biol. 2009;41(1):40-59. https://doi.org/10.1016/j.biocel.2008.06.010 PMid:18662800 PMCid:PMC2637808
38. Hewlings S, Kalman D. Curcumin: human health review. Foods. 2017;6(10):92. https://doi.org/10.3390/foods6100092 PMid:29065496 PMCid:PMC5664031
39. Somani R, Singhai A. Alpinia galanga review. Int J Pharm Sci Rev Res. 2015;31(1):120-4.
40. Shoba G, et al. Piperine enhances curcumin bioavailability. Planta Med. 1998;64(4):353-6. https://doi.org/10.1055/s-2006-957450 PMid:9619120
41. Largo R, et al. Glucosamine inhibits NF-κB activation. Osteoarthritis Cartilage. 2003;11(4):290-8. https://doi.org/10.1016/S1063-4584(03)00028-1 PMid:12681956
42. Hua J, et al. Glucosamine suppresses ADAM-TS and MMP. Inflamm Res. 2005;54(4):127-32. https://doi.org/10.1007/s00011-004-1333-6 PMid:15883746
43. Poeckel D, Werz O. Boswellic acids actions. Curr Med Chem. 2006;13(28):3359-69. https://doi.org/10.2174/092986706779010333 PMid:17168710
44. Aggarwal BB, Harikumar KB. Curcumin therapeutic effects. Biochem Pharmacol. 2009;78(11):1340-51. 45. Henrotin Y, Priem F, Mobasheri A. Curcumin for OA. SpringerPlus. 2013;2:56. https://doi.org/10.1186/2193-1801-2-56 PMid:23487030 PMCid:PMC3591524
46. Winther K, Apel K, Thamsborg G. Rosehip powder results. Scand J Rheumatol. 2005;34(4):302-8. https://doi.org/10.1080/03009740510018624 PMid:16195164
47. Rein E, Kharazmi A, Winther K. Standardized rosehip powder. Osteoarthritis Cartilage. 2004;12(8):L63.
48. Basch E, Ulbricht C, Kuo G, Szapary P. Fenugreek review. Altern Med Rev. 2003;8(1):20-7.
49. Chandrasekhar K, Kapoor J, Anishetty S. Ashwagandha stress study. Indian J Psychol Med. 2012;34(3):255-62. https://doi.org/10.4103/0253-7176.106022 PMid:23439798 PMCid:PMC3573577
50. Lopresti AL, Smith SJ, Malvi H, Kodgule R. Ashwagandha stress trial. Medicine (Baltimore). 2019;98(37):e17186. https://doi.org/10.1097/MD.0000000000017186 PMid:31517876 PMCid:PMC6750292
51. Sutar NG, Pal SC. Anti-arthritic activity of Alpinia galanga. Indian J Nat Prod Resour. 2012;3(3):417-22.
52. Kapoor M, et al. Alpinia galanga analgesic activity. Phytother Res. 2014;28(8):1210-6.
53. Somani R, Singhai A. Alpinia galanga anti-inflammatory effects. Int J Pharm Sci Rev Res. 2015;31(1):120-4.
54. Shoba G, et al. Piperine-curcumin pharmacokinetics. Planta Med. 1998;64(4):353-6. https://doi.org/10.1055/s-2006-957450 PMid:9619120
55. Atal CK, Dubey RK, Singh J. Piperine inhibits metabolism. J Pharmacol Exp Ther. 1985;232(1):258-62. https://doi.org/10.1016/S0022-3565(25)20081-7 PMid:3917507
56. Srinivasan K. Black pepper and piperine. Crit Rev Food Sci Nutr. 2007;47(8):735-48. https://doi.org/10.1080/10408390601062054 PMid:17987447
57. Vyas AR, Singh SV. Dietary agents in cancer prevention. Nutr Cancer. 2011;63(3):329-41.
58. Migliore A, Procopio S. Joint-protective supplements. Clin Interv Aging. 2015;10:1951-62.
59. Martel-Pelletier J, Barr AJ, Cicuttini FM, et al. Osteoarthritis. Nat Rev Dis Primers. 2016;2:16072. https://doi.org/10.1038/nrdp.2016.72 PMid:27734845
60. Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for OA. Br J Sports Med. 2018;52(3):167-75. https://doi.org/10.1136/bjsports-2016-097333 PMid:29018060
61. Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393(10182):1745-59. https://doi.org/10.1016/S0140-6736(19)30417-9 PMid:31034380
62. Safiri S, Kolahi AA, Smith E, et al. Global burden of OA. Ann Rheum Dis. 2020;79(6):819-28. https://doi.org/10.1136/annrheumdis-2019-216515
PMid:32398285 63. Ong CK, Lirk P, Tan CH, Seymour RA. NSAIDs update. Clin Med Res. 2007;5(1):19-34. https://doi.org/10.3121/cmr.2007.698 PMid:17456832 PMCid:PMC1855338
64. Gupta RC, Lall R, Srivastava A, Sinha A. Nutraceuticals in arthritis. In: Nutraceuticals. Academic Press; 2016. p. 717-33. https://doi.org/10.1016/B978-0-12-802147-7.00013-9
65. Srivastava S, Lal VK, Pant KK. Polyherbal formulations. Indian J Tradit Knowl. 2021;20(3):551-9.
66. Shahid M, Rafiq M, Khan AA, et al. Multi-herbal formulations review. J Ethnopharmacol. 2022;285:114905.
67. Sophia Fox AJ, Bedi A, Rodeo SA. Articular cartilage science. Sports Health. 2009;1(6):461-8. https://doi.org/10.1177/1941738109350438 PMid:23015907 PMCid:PMC3445147
68. Martel-Pelletier J, et al. Osteoarthritis. Nat Rev Dis Primers. 2016;2:16072. https://doi.org/10.1038/nrdp.2016.72 PMid:27734845
69. Reginster JY, et al. Glucosamine long-term effects. Lancet. 2001;357(9252):251-6. https://doi.org/10.1016/S0140-6736(00)03610-2 PMid:11214126
70. Herrero-Beaumont G, et al. Glucosamine sulfate trial. Arthritis Rheum. 2007;56(2):555-67. https://doi.org/10.1002/art.22371 PMid:17265490
71. Chrubasik C, Roufogalis BD, Müller-Ladner U, Chrubasik S. Rosehip review. Phytother Res. 2008;22(6):725-33. https://doi.org/10.1002/ptr.2400 PMid:18384191
72. Henrotin Y, Kurz B, Aigner T. Oxygen and ROS in OA. Osteoarthritis Cartilage. 2005;13(8):643-54. https://doi.org/10.1016/j.joca.2005.04.002 PMid:15936958
73. Jang EJ, Kim JS, Lee SY, et al. Rosehip antioxidant effects. J Med Food. 2018;21(7):690-8.
74. Goldring MB, Otero M. Inflammation in OA. Curr Opin Rheumatol. 2011;23(5):471-8. https://doi.org/10.1097/BOR.0b013e328349c2b1 PMid:21788902 PMCid:PMC3937875
75. Kapoor M, et al. Proinflammatory cytokines in OA. Nat Rev Rheumatol. 2011;7(1):33-42. https://doi.org/10.1038/nrrheum.2010.196 PMid:21119608
76. Sengupta K, et al. 5-Loxin® study. Arthritis Res Ther. 2008;10(4):R85. https://doi.org/10.1186/ar2461 PMid:18667054 PMCid:PMC2575633
77. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin. Int J Biochem Cell Biol. 2009;41(1):40-59. https://doi.org/10.1016/j.biocel.2008.06.010 PMid:18662800 PMCid:PMC2637808
78. Shoba G, et al. Piperine-curcumin pharmacokinetics. Planta Med. 1998;64(4):353-6. https://doi.org/10.1055/s-2006-957450 PMid:9619120
79. Henrotin Y, Priem F, Mobasheri A. Curcumin for OA. J Int Med Res. 2019;47(3):97-116.
80. Basch E, Ulbricht C, Kuo G, Szapary P, Smith M. Fenugreek review. Altern Med Rev. 2003;8(1):20-7.
81. Reddy AM, Reddy CM, et al. Anti-inflammatory activity of fenugreek. Indian J Pharm Sci. 2012;74(2):171-5.
82. Winther K, Apel K, Thamsborg G. Rosehip for OA. Osteoarthritis Cartilage. 2005;13(1):92-8.
83. Ghosh P, Cheras PA. Vascular mechanisms in OA. Best Pract Res Clin Rheumatol. 2001;15(5):693-709. https://doi.org/10.1053/berh.2001.0188 PMid:11812016
84. Bolduc JA, Collins JA, Loeser RF. ROS and OA. J Orthop Res. 2019;37(10):1505-15.
85. Willich SN, Erlendson B, Winther K. Rosehip herbal remedy. Phytother Res. 2010;24(1):1-3.
86. Škottová N, Krecman V. Saponins and atherosclerosis. Curr Pharm Des. 2005;11(2):233-43.
87. Henrotin Y. Nutraceuticals: do they work? Joint Bone Spine. 2011;78(2):154-60.
88. Fillingim RB. Stress-pain interactions. Pain. 2017;158 Suppl 1:S119-27. https://doi.org/10.1097/j.pain.0000000000000775 PMid:27902569 PMCid:PMC5350021
89. Lopresti AL, Smith SJ, Malvi H, Kodgule R. Ashwagandha stress trial. Medicine (Baltimore). 2019;98(37):e17186. https://doi.org/10.1097/MD.0000000000017186 PMid:31517876 PMCid:PMC6750292
90. Sandhu JS, Shah B, Shenoy S, Chauhan S. Withania somnifera and muscle strength. J Ayurveda Integr Med. 2012;3(4):209-14. https://doi.org/10.4103/0975-9476.104444 PMid:23326093 PMCid:PMC3545242
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