A Systematic Review on Hepatoprotective Medicinal Plants, Their Bioactive Compounds, and Pharmaceutical Formulations
Abstract
The liver is a vital organ responsible for metabolism, detoxification, and maintaining physiological balance, yet it is highly vulnerable to damage from alcohol, drugs, toxins, and infections. Conventional treatments for liver disorders often have limited efficacy and may cause additional hepatic stress, highlighting the need for safer alternatives. Medicinal plants have emerged as promising hepatoprotective agents due to their antioxidant, anti-inflammatory, antifibrotic, and antiviral properties. Herbs such as Silybum marianum, Phyllanthus niruri, Picrorhiza kurroa, Curcuma longa, Tinospora cordifolia, Glycyrrhiza glabra, Boerhaavia diffusa, and Ginkgo biloba have shown significant protective effects in experimental models.2 Popular herbal formulations like silymarin and Liv-52 are widely used for liver disorders and demonstrate beneficial outcomes in preclinical studies. In India, particularly in Chhattisgarh, these plants form an integral part of traditional medicine and exhibit promising local effectiveness. However, despite strong experimental evidence, clinical validation remains limited. To achieve global acceptance, further research focusing on standardized extracts, well-designed clinical trials, and modern dosage formulations is essential to confirm the therapeutic potential of these hepatoprotective medicinal plants.
Keywords: Hepatoprotective agents, Herbal medicines, Polyherbal formulations, Liver disorders
Keywords:
Hepatoprotective agents, Herbal medicines, Polyherbal formulations, Liver disordersDOI
https://doi.org/10.22270/jddt.v15i12.7500References
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