Comparative study of synthetic and natural superdisintegrants to enhance the disintegration of mouth dissolving tablets
Abstract
Mouth dissolving tablets have received ever-increasing demand during the last decade, particularly the Mouth dissolving tablets drug delivery systems formulated with natural polymers have more demand because natural materials are easily available, easy to administer, non-toxic and non-irritant nature etc. The main aim of the present study was to formulate the Mouth dissolving tablets of Aceclofenac using mango pectin powder, Guar Gum and Aloe Vera mucilage. The results obtained from the natural polymer were compared with the synthetic superdisintegrants such as Sodium Starch Glycolate, Crosspovidone and Croscarmellose Sodium. The Mouth dissolving tablets different superdisintegrants with varying concentrations were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, drug content, disintegration time and drug release. The mouth dissolving tablets made from natural disintegrants was found superior over a mouth dissolving tablets made from a synthetic polymer.
Keywords: Mouth dissolving tablets, synthetic disintegrants, and natural disintegrants.
Keywords:
Mouth dissolving tablets, synthetic disintegrants, natural disintegrantsDOI
https://doi.org/10.22270/jddt.v15i12.7496References
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Copyright (c) 2025 Yogendra Sahu , Bharti Sahu , Mohan Lal Kori
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