Analytical evaluation of C. pictus for its therapeutic properties and antioxidant activity in relation to anticancer potential against selected cancer cell lines
Abstract
Medicinal plants play an important role in medical care throughout history, including the modern period. Costus pictus, also known as the 'insulin plant,' exhibits numerous bioactivities, including anti-diabetic, antioxidant, anticancer, anti-inflammatory, and hepatoprotective properties. In the present investigation, C. pictus leaves were extracted using ethanol and petroleum ether, and GC-MS analysis revealed 26 and 24 chemical components, respectively. These compounds are used significantly in pharmacology. The antioxidant capabilities of medicinal plants have been studied since they may be in possession of a number of bioactive molecules. It has been demonstrated that antioxidants revert the development of cancer through micromanagement of tumours, and medicinal plants are a rich source of new and powerful antioxidants and anticancer bioactive molecules. In the present study, the anticancer potential of C. pictus leaf extracts in water, ethanol, and petroleum ether against MCF-7 cancer cell lines was evaluated. The MCF-7 cell line was inhibited by all three extracts in a dose-dependent manner.
Key words: anti-cancer, anti-inflammatory, pharmacology, GC-MS, MCF-7 cancer cell lines,
Keywords:
anti-cancer, anti-inflammatory, pharmacology, GC-MS, MCF-7 cancer cell linesDOI
https://doi.org/10.22270/jddt.v15i8.7338References
1. Rohit KB, Preliminary test of phytochemical screening of crude ethanolic and aqueous extract of Moringa pterygosperma Gaertn, Journal of Pharmacognosy and Phytochemistry, 2015; 4(1): 7-9.
2. Farhat MB, Landoulsi A, Hamada RC, Sotomayor JA, and María JJ, Characterization and quantification of phenolic compounds and antioxidant properties of Salvia species growing in different habitats, Indus. Crops Prod, 2013;(49):904-914. https://doi.org/10.1016/j.indcrop.2013.06.047
3. Iqbal E, Salim KA, Lim LB, Phytochemical screening, total phenolics and antioxidant activities of bark and leaf extracts of Goniothalamus velutinus (Airy Shaw) from Brunei Darussalam. J. King Saud Univ. Sci, 2015; (27): 224-232. https://doi.org/10.1016/j.jksus.2015.02.003
4. Jain R, Jain SK, (2011). Screening of in-vitro cytotoxic activity of some medicinal plants used traditionally to treat cancer in Chhattisgarh state, India. Asian Pac. J. Trop. Biomed, 2011; (1): 147-150. https://doi.org/10.1016/S2221-1691(11)60144-5
5. Huang WY, Cai YZ, and Zhang Y, Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutrition and Cancer, 2010; (62): 1-20. https://doi.org/10.1080/01635580903191585 PMid:20043255
6. Milaeva ER, Metal- based antioxidants- potential therapeutic candidates for prevention the oxidative stree- related carcinogenesis: mini- review. Current Topics in Medicinal Chemistry, 2011; (11): 2703-2713. https://doi.org/10.2174/156802611798040741 PMid:22039870
7. Yesiloglu Y, Aydin H, and Kilic I, In vitro antioxidant activity of various extracts of ginger (Zinger officinale L.) seed. Asian Journal of Chemistry, 2013; 25(7): 3573-3578. https://doi.org/10.14233/ajchem.2013.13657
8. Firdaus M, Prihanto AA, Nurdiani R, Antioxidant and cytotoxic activity of Acanthus ilicifolius flower. Asian Pac. J. Trop. Biomed, 2013;(3): 17-21. https://doi.org/10.1016/S2221-1691(13)60017-9 PMid:23570011
9. AryaV, Kashyap CP, Bandana T, Shiksha S, Sweta K, Verma P, Human cancer cell lines, A brief communication, J Chem. Pharm. Res, 2011;3(6): 514-520.
10. Sivaprabha J, Dharani B, Padma PR, Sumathi S, Induction of DNA damage by the leaves and rhizomes of Curcuma amada Roxb in breast cancer cell lines. Journal of Acute Disease, 2015; 12-17. https://doi.org/10.1016/S2221-6189(14)60075-5
Published
Abstract Display: 203 
PDF Downloads: 311 PDF Downloads: 28 How to Cite
Issue
Section
Copyright (c) 2025 Ashwini, Ramachandra Y. L. , Pawar Sagar Namdeo , Prerana Pramod Dange , Padmalatha S. Rai
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.