Imidazole Phenanthroline Derivatives: A Promising Application in Modern Medicine
Abstract
Purpose: The primary objective of this study is to create a new class of imidazole phenanthroline compounds that target the 1,10-phenanthroline core for its antifungal and antibacterial properties.
Methods: Commercially available 1,10-phenanthroline (phen) was nitrated with potassium bromide in the presence of sulfuric and nitric acids to get 1,10-phenanthroline-5,6-dione (phendione), an intermediate molecule, which served as the starting compound for the synthesis of 1H-imidazo [4,5-f] [1,10] phenanthroline compounds. This intermediate product was dissolved in glacial acetic acid and then reacted with different benzaldehydes while ammonium acetate acted as a catalyst. Thin Layer Chromatography (TLC) was used to track the reaction's progress and the purity of the product. Their biological efficacy against in vitro bacterial and fungal growth was also investigated. The antimicrobial potential of the investigated compounds when compared to the standards Clotrimazole and Streptomycin, respectively, revealed impressive antifungal and antibacterial properties.
Results: A series of compounds were synthesized successfully and characterized by various analytical techniques such as NMR, IR and ESI-mass spectroscopy. The compounds possess remarkable antibacterial and antifungal potential.
Conclusion: A series of imidazole phenanthrolines were synthesized and found to have antimicrobial activities.
Keywords: phenanthrene, imidazole phenanthroline, 1,10-phenanthroline, potassium bromide, 1,10-phenanthroline-5,6-dione, 1H-imidazo [4,5-f] [1,10] phenanthroline
Keywords:
phenanthrene, imidazole phenanthroline, 1,10-phenanthroline, potassium bromide, 1,10-phenanthroline-5,6-dione, 1H-imidazo [4,5-f] [1,10]DOI
https://doi.org/10.22270/jddt.v15i6.7230References
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