Anti-Inflammatory Potential of Medicinal Plants in the Management of Inflammatory Diseases: A Review of Mechanisms and Bioactive Compounds
Abstract
Inflammatory diseases, such as arthritis, asthma, and inflammatory bowel disease, present ongoing health challenges due to their chronic nature and the complexity of immune responses involved. While synthetic anti-inflammatory drugs are commonly used, they are often associated with adverse effects that drive a growing interest in natural therapeutic alternatives. Medicinal plants, recognized for their anti-inflammatory potential, offer promising avenues for safer treatment options. This review explores the current status and systematic strategies for discovering anti-inflammatory drugs from phytoconstituents found in medicinal plants. Bioactive compounds such as flavonoids, alkaloids, terpenoids, and polyphenols exhibit significant anti-inflammatory activity by interacting with key molecular pathways. These include the inhibition of pro-inflammatory cytokines, downregulation of COX and LOX enzymes, and reduction of oxidative stress. Despite their potential, challenges like bioavailability, lack of standardization pose obstacles to widespread clinical adoption. Recent advances in high-throughput screening, computational biology, and formulation technologies are paving the way for more targeted and efficient phytoconstituent-based drug discovery. This review highlights not only the therapeutic promise of phytochemicals but also emphasizes integrated research strategies necessary for their successful development into clinically approved anti-inflammatory agents.
Keywords: Natural therapeutics, Bioactive compounds, Inflammation management, Oxidative stress reduction.
Keywords:
Natural therapeutics, Bioactive compounds, Inflammation management, Oxidative stress reductionDOI
https://doi.org/10.22270/jddt.v15i6.7203References
1. Denko CW. A role for neuropeptides in inflammation. In Biochemistry of inflammation 1992 Feb 29 (pp. 177-181). Dordrecht: Springer Netherlands. https://doi.org/10.1007/978-94-011-2996-1_9
2. Singh A, Malhotra S, Subban R. Anti-inflammatory and analgesic agents from Indian medicinal plants. International journal of integrative biology. 2008;3(1):57-72.
3. Beg S, Swain S, Hasan H, Barkat MA, Hussain MS. Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives. Pharmacognosy reviews. 2011 Jul;5(10):120. https://doi.org/10.4103/0973-7847.91102 PMid:22279370 PMCid:PMC3263046
4. Bauri RK, Tigga MN, Kullu SS. A review on use of medicinal plants to control parasites. Indian Journal of Natural Products and Resources (IJNPR)[Formerly Natural Product Radiance (NPR)]. 2015 Dec 18;6(4):268-77.
5. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nature immunology. 2005 Dec 1;6(12):1191-7. https://doi.org/10.1038/ni1276 PMid:16369558
6. Gilroy DW, Lawrence T, Perretti M, Rossi AG. Inflammatory resolution: new opportunities for drug discovery. Nature reviews Drug discovery. 2004 May 1;3(5):401-16. https://doi.org/10.1038/nrd1383 PMid:15136788
7. Bottazzi B, Doni A, Garlanda C, Mantovani A. An integrated view of humoral innate immunity: pentraxins as a paradigm. Annual review of immunology. 2009 Apr 23;28: 157-83. https://doi.org/10.1146/annurev-immunol-030409-101305 PMid:19968561
8. Lanas A. Nonsteroidal anti-inflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract: a trip from peptic ulcer to colon cancer. The American journal of the medical sciences. 2009 Aug 1;338(2):96-106. https://doi.org/10.1097/MAJ.0b013e3181ad8cd3 PMid:19680014
9. Rossi S: Australian medicines handbook, 2006: 143-145
10. Kandulski A, Venerito M, Malfertheiner P. Non-steroidal anti-inflammatory drugs (NSAIDs)-balancing gastrointestinal complications and the cardiovascular risk. Deutsche Medizinische Wochenschrift (1946). 2009 Jul 31;134(33):1635-40. https://doi.org/10.1055/s-0029-1233993 PMid:19650027
11. Patil KR, Mahajan UB, Unger BS, Goyal SN, Belemkar S, Surana SJ, Ojha S, Patil CR. Animal models of inflammation for screening of anti-inflammatory drugs: implications for the discovery and development of phytopharmaceuticals. International journal of molecular sciences. 2019 Sep 5;20(18):4367. https://doi.org/10.3390/ijms20184367 PMid:31491986 PMCid:PMC6770891
12. Stables MJ, Gilroy DW. Old and new generation lipid mediators in acute inflammation and resolution. Progress in lipid research. 2011 Jan 1;50(1):35-51. https://doi.org/10.1016/j.plipres.2010.07.005 PMid:20655950
13. Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nature Reviews Immunology. 2015 Aug;15(8):511-23. https://doi.org/10.1038/nri3859 PMid:26139350 PMCid:PMC4606863
14. Benito PB, Lanza AM, Sen AM, Galindez JD, Matellano LF, Gómez AS, Martínez MJ. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Medica. 2000 May;66(04):324-8. https://doi.org/10.1055/s-2000-8549 PMid:10865447
15. Safayhi H, Sailer ER. Anti-inflammatory actions of pentacyclic triterpenes. Planta medica. 1997 Dec;63(06):487-93. https://doi.org/10.1055/s-2006-957748 PMid:9434597
16. Busse WW. Leukotrienes and inflammation. American journal of respiratory and critical care medicine. 1998 Jun 1;157(6): S210-3. https://doi.org/10.1164/ajrccm.157.6.mar-1 PMid:9445302
17. Prieto JM, Giner RM, Recio MC, Schinella G, Máñez S, Ríos JL. Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum. Planta medica. 2002 Apr;68(04): 359-60. https://doi.org/10.1055/s-2002-26747 PMid:11988863
18. Cho JY, Yoo ES, Baik KU, Park MH, Han BH. In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-α production and its modulation by known TNF-α antagonists. Planta Medica. 2001;67(03):213-18. https://doi.org/10.1055/s-2001-12005 PMid:11345690
19. Kulkarni RG, Achaiah G, Narahari Sastry G. Novel targets for anti-inflammatory and antiarthritic agents. Current pharmaceutical design. 2006 Jul 1;12(19):2437-54. https://doi.org/10.2174/138161206777698945 PMid:16842190
20. Lawrence T, Willoughby DA, Gilroy DW. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nature Reviews Immunology. 2002 Oct 1;2(10):787-95. https://doi.org/10.1038/nri915 PMid:12360216
21. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2014 Jun 1;69(Suppl_1): S4-9. https://doi.org/10.1093/gerona/glu057 PMid:24833586
22. Larsen GL, Henson PM. Mediators of inflammation. Annual review of immunology. 1983 Apr;1(1):335-59. https://doi.org/10.1146/annurev.iy.01.040183.002003 PMid:6399978
23. Hersh EM, Bodey GP. Leukocytic mechanisms in inflammation. Annual Review of Medicine. 1970 Feb;21(1):105-32. https://doi.org/10.1146/annurev.me.21.020170.000541 PMid:4913944
24. Biswas SK. Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox? Oxidative medicine and cellular longevity. 2016 Oct;2016. https://doi.org/10.1155/2016/5698931 PMid:26881031 PMCid:PMC4736408
25. Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran pathologic basis of disease, professional edition e-book. Elsevier health sciences; 2014 Aug 27.
26. Anderson MT, Staal FJ, Gitler C, Herzenberg LA, Herzenberg LA. Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway. Proceedings of the National Academy of Sciences. 1994 Nov 22;91(24):11527-31. https://doi.org/10.1073/pnas.91.24.11527 PMid:7526398 PMCid:PMC45264
27. Flohé L, Brigelius-Flohé R, Saliou C, Traber MG, Packer L. Redox regulation of NF-kappa B activation. Free Radical Biology and Medicine. 1997 Jan 1;22(6):1115-26. https://doi.org/10.1016/S0891-5849(96)00501-1 PMid:9034250
28. Hortelano S. Molecular basis of the anti-inflammatory effects of terpenoids. Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets-Inflammation & Allergy) (Discontinued). 2009 Mar 1;8(1):28-39. https://doi.org/10.2174/187152809787582534 PMid:19275691
29. Lee JH, Choi JK, Noh MS, Hwang BY, Hong YS, Lee JJ. Anti-inflammatory effect of kamebakaurin in in vivo animal models. Planta medica. 2004 Jun;70(06):526-30. https://doi.org/10.1055/s-2004-827152 PMid:15241890
30. Guo RF, Ward PA. Role of C5a in inflammatory responses. Annu. Rev. Immunol. 2005 Apr 23;23: 821-52. https://doi.org/10.1146/annurev.immunol.23.021704.115835 PMid:15771587
31. Okoli CO, Akah PA. Mechanisms of the anti-inflammatory activity of the leaf extracts of Culcasia scandens P. Beauv (Araceae). Pharmacology Biochemistry and Behavior. 2004 Nov 1;79(3):473-81. https://doi.org/10.1016/j.pbb.2004.08.012 PMid:15582018
32. Calixto JB, Otuki MF, Santos AR. Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor κ B (NF-κB). Planta medica. 2003 Nov;69(11):973-83. https://doi.org/10.1055/s-2003-45141 PMid:14735432
33. Dahanukar SA, Kulkarni RA, Rege NN. Pharmacology of medicinal plants and natural products. Indian journal of pharmacology. 2000 Jul 1;32(4):81-118.
34. Lahlou M. The success of natural products in drug discovery. 2013, 4, 17-31. https://doi.org/10.4236/pp.2013.43A003
35. Katiyar C, Gupta A, Kanjilal S, Katiyar S. Drug discovery from plant sources: An integrated approach. AYU (An international quarterly journal of research in Ayurveda). 2012 Jan 1;33(1):10-9. https://doi.org/10.4103/0974-8520.100295 PMid:23049178 PMCid:PMC3456845
36. Gautam R, Jachak SM. Recent developments in anti‐inflammatory natural products. Medicinal research reviews. 2009 Sep;29(5):767-820. https://doi.org/10.1002/med.20156 PMid:19378317
37. Mitra S, Kar S, Surajlata K, Banerjee ER. Screening of novel natural product derived compounds for drug discovery in inflammation. J. Plant Biochem. Physiol. 2016;3: 159. https://doi.org/10.4172/2329-9029.1000159
38. Durmowicz AG, Stenmark KR. Mechanisms of structural remodeling in chronic pulmonary hypertension. Pediatrics in Review. 1999 Nov 1;20(11): 91-102. https://doi.org/10.1542/pir.20.11.e91
39. Tiwari S. Plants: A rich source of herbal medicine. Journal of natural products. 2008;1(0):27-35.
40. Pynam H, Dharmesh SM. Antioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF-α mediated inflammatory/tumor markers. Biomedicine & Pharmacotherapy. 2018 Oct 1;106: 98-108. https://doi.org/10.1016/j.biopha.2018.06.053 PMid:29957472
41. Neetu Rajput NR, Srivastava DN, Sahni YP, Nigam JM. Role of mediators in anti-inflammatory activity of Adhatoda vasica on carrageenin induced paw oedema in rats.2006;5:32-6.
42. Jayanthi MK, Dhar M, Jayanthi M. Anti-inflammatory effects of Allium sativum (garlic) in experimental rats. Biomedicine. 2011;31(1):84-9.
43. Karimi E, Oskoueian E, Karimi A, Noura R, Ebrahimi M. Borago officinalis L. flower: A comprehensive study on bioactive compounds and its health-promoting properties. Journal of Food Measurement and Characterization. 2018 Jun;12: 826-38. https://doi.org/10.1007/s11694-017-9697-9
44. Chibli LA, Rodrigues KC, Gasparetto CM, Pinto NC, Fabri RL, Scio E, Alves MS, Del-Vechio-Vieira G, Sousa OV. Anti-inflammatory effects of Bryophyllum pinnatum (Lam.) Oken ethanol extract in acute and chronic cutaneous inflammation. Journal of ethnopharmacology. 2014 Jun 11;154(2):330-8. https://doi.org/10.1016/j.jep.2014.03.035 PMid:24727190
45. Alluri VK, Kundimi S, Sengupta K, Golakoti T, Kilari EK. An anti-inflammatory composition of Boswellia serrata resin extracts alleviates pain and protects cartilage in monoiodoacetate-induced osteoarthritis in rats. Evidence-Based Complementary and Alternative Medicine. 2020 May 22;2020. https://doi.org/10.1155/2020/7381625 PMid:32565872 PMCid:PMC7261341
46. Vishnoi H, Bodla RB, Kant R, Bodla RB. Green Tea (Camellia sinensis) and its antioxidant property: A review. International Journal of Pharmaceutical Sciences and Research. 2018 May 1;9(5): 1723-36.
47. Sanati S, Razavi BM, Hosseinzadeh H. A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome. Iranian journal of basic medical sciences. 2018 May;21(5):439.
48. Lee HJ, Hyun EA, Yoon WJ, Kim BH, Rhee MH, Kang HK, Cho JY, Yoo ES. In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts. Journal of ethnopharmacology. 2006 Jan 16;103(2):208-16. https://doi.org/10.1016/j.jep.2005.08.009 PMid:16182479
49. Antonisamy P, Agastian P, Kang CW, Kim NS, Kim JH. Anti-inflammatory activity of rhein isolated from the flowers of Cassia fistula L. and possible underlying mechanisms. Saudi journal of biological sciences. 2019 Jan 1;26(1):96-104. https://doi.org/10.1016/j.sjbs.2017.04.011 PMid:30622412 PMCid:PMC6319193
50. Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer research. 1991 Feb 1;51(3):813-9.
51. Francis JA, Raja SN, Nair MG. Bioactive terpenoids and guggulusteroids from Commiphora mukul gum resin of potential anti‐inflammatory interest. Chemistry & biodiversity. 2004 Nov;1(11):1842-53. https://doi.org/10.1002/cbdv.200490138 PMid:17191820
52. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M, Sohraby M, Shahlari N, Hamidpour R. Russian olive (Elaeagnus angustifolia L.): From a variety of traditional medicinal applications to its novel roles as active antioxidant, anti-inflammatory, anti-mutagenic and analgesic agent. Journal of traditional and complementary medicine. 2017 Jan 1;7(1):24-9. https://doi.org/10.1016/j.jtcme.2015.09.004 PMid:28053884 PMCid:PMC5198788
53. Silva J, Abebe W, Sousa SM, Duarte VG, Machado MI, Matos FJ. Analgesic and anti-inflammatory effects of essential oils of Eucalyptus. Journal of ethnopharmacology. 2003 Dec 1;89(2-3):277-83. https://doi.org/10.1016/j.jep.2003.09.007 PMid:14611892
54. Michel P, Dobrowolska A, Kicel A, Owczarek A, Bazylko A, Granica S, Piwowarski JP, Olszewska MA. Polyphenolic profile, antioxidant and anti-inflammatory activity of eastern teaberry (Gaultheria procumbens L.) leaf extracts. Molecules. 2014 Dec 8;19(12):20498-520. https://doi.org/10.3390/molecules191220498 PMid:25493634 PMCid:PMC6271927
55. Sripradha R, Magadi SG. Efficacy of garcinia cambogia on body weight, inflammation and glucose tolerance in high fat fed male wistar rats. Journal of Clinical and Diagnostic Research: JCDR. 2015 Feb;9(2):BF01. https://doi.org/10.7860/JCDR/2015/12045.5577 PMid:25859449 PMCid:PMC4378731
56. Thiyagarajan P, Chandrasekaran CV, Deepak HB, Agarwal A. Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. Inflammopharmacology. 2011 Aug;19: 235-41. https://doi.org/10.1007/s10787-011-0080-x PMid:21328091
57. Vinh LB, Nguyet NT, Thanh CD, Huong TT, Tram LH, Van Thong N, Minh NH, Thao NP, Hwang I, Yang SY, Kim YH. Chemical constituents of Vietnamese mangrove Hibiscus tiliaceus with antioxidant and alpha-glucosidase inhibitory activity. Natural Product Research. 2021 Aug 19;35(17):2899-904. https://doi.org/10.1080/14786419.2019.1672065 PMid:31564138
58. Kaithwas G, Majumdar DK. Therapeutic effect of Linum usitatissimum (flaxseed/linseed) fixed oil on acute and chronic arthritic models in albino rats. Inflammopharmacology. 2010 Jun;18: 127-36. https://doi.org/10.1007/s10787-010-0033-9 PMid:20157785
59. Simon JP, Evan Prince S. Aqueous leaves extract of Madhuca longifolia attenuate diclofenac‐induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines. Journal of cellular biochemistry. 2018 Jul;119(7): 6125-35. https://doi.org/10.1002/jcb.26812 PMid:29574991
60. Li Y, Liu Y, Ma A, Bao Y, Wang M, Sun Z. In vitro antiviral, anti-inflammatory, and antioxidant activities of the ethanol extract of Mentha piperita L. Food science and biotechnology. 2017 Dec;26: 1675-83. https://doi.org/10.1007/s10068-017-0217-9 PMid:30263705 PMCid:PMC6049716
61. Minaiyan M, Asghari G, Taheri D, Saeidi M, Nasr-Esfahani S. Anti-inflammatory effect of Moringa oleifera Lam. seeds on acetic acid-induced acute colitis in rats. Avicenna journal of phytomedicine. 2014 Mar;4(2):127.
62. Manaharan T, Thirugnanasampandan R, Jayakumar R, Ramya G, Ramnath G, Kanthimathi MS. Antimetastatic and anti-inflammatory potentials of essential oil from edible Ocimum sanctum leaves. The Scientific World Journal. 2014 Jan 1;2014. https://doi.org/10.1155/2014/239508 PMid:25431779 PMCid:PMC4238170
63. Sahranavard S, Kamalinejad M, Faizi M. Evaluation of anti-inflammatory and anti-nociceptive effects of defatted fruit extract of Olea europaea. Iranian journal of pharmaceutical research: IJPR. 2014;13(Suppl):119.
64. Alkhalaf MI, Alansari WS, Ibrahim EA, ELhalwagy ME. Anti-oxidant, anti-inflammatory and anti-cancer activities of avocado (Persea americana) fruit and seed extract. Journal of King Saud University-Science. 2019 Oct 1;31(4):1358-62. https://doi.org/10.1016/j.jksus.2018.10.010
65. Kaushik D, Kumar A, Kaushik P, Rana AC. Analgesic and anti-inflammatory activity of Pinus roxburghii Sarg. Advances in Pharmacological and Pharmaceutical Sciences. 2012;2012. https://doi.org/10.1155/2012/245431 PMid:22761611 PMCid:PMC3384912
66. Buapool D, Mongkol N, Chantimal J, Roytrakul S, Srisook E, Srisook K. Molecular mechanism of anti-inflammatory activity of Pluchea indica leaves in macrophages RAW 264.7 and its action in animal models of inflammation. Journal of ethnopharmacology. 2013 Mar 27;146(2):495-504. https://doi.org/10.1016/j.jep.2013.01.014 PMid:23353896
67. Guerrero E, Abad A, Montenegro G, Del Olmo E, López-Pérez JL, San Feliciano A. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharmaceutical Biology. 2013 May 1;51(5):566-72. https://doi.org/10.3109/13880209.2012.749921 PMid:23363067
68. Tasleem F, Azhar I, Ali SN, Perveen S, Mahmood ZA. Analgesic and anti-inflammatory activities of Piper nigrum L. Asian Pacific journal of tropical medicine. 2014 Sep 1;7:S 461-8. https://doi.org/10.1016/S1995-7645(14)60275-3 PMid:25312168
69. Mongold JJ, Susplugas P, Taillade C, Serrano JJ. Anti-inflammatory activity of Ribes nigrum leaf extract in rats.1993,109-116.
70. Larsen E, Kharazmi A, Christensen LP, Christensen SB. An anti-inflammatory galactolipid from Rose hip (rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro. Journal of Natural Products. 2003 Jul 25;66(7):994-5. https://doi.org/10.1021/np0300636 PMid:12880322
71. Rahbardar MG, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. Biomedicine & Pharmacotherapy. 2017 Feb 1;86: 441-9. https://doi.org/10.1016/j.biopha.2016.12.049 PMid:28012923
72. Maistro EL, Terrazzas PM, Perazzo FF, Gaivão IO, Sawaya AC, Rosa PC. Salix alba (white willow) medicinal plant presents genotoxic effects in human cultured leukocytes. Journal of Toxicology and Environmental Health, Part A. 2019 Dec 17;82(23-24):1223-34. https://doi.org/10.1080/15287394.2019.1711476 PMid:31906808
73. Ghorbani A, Esmaeilizadeh M. Pharmacological properties of Salvia officinalis and its components. Journal of traditional and complementary medicine. 2017 Oct 1;7(4):433-40. https://doi.org/10.1016/j.jtcme.2016.12.014 PMid:29034191 PMCid:PMC5634728
74. Anwikar S, Bhitre M. Study of the synergistic anti-inflammatory activity of Solanum xanthocarpum Schrad and Wendl and Cassia fistula Linn. International journal of Ayurveda research. 2010 Jul;1(3):167. https://doi.org/10.4103/0974-7788.72489 PMid:21170209 PMCid:PMC2996575
75. Seigner J, Junker-Samek M, Plaza A, D 'Urso G, Masullo M, Piacente S, Holper-Schichl YM, de Martin R. A Symphytum officinale root extract exerts anti-inflammatory properties by affecting two distinct steps of NF-κB signalling. Frontiers in pharmacology. 2019 Apr 26; 10:289. https://doi.org/10.3389/fphar.2019.00289 PMid:31105555 PMCid:PMC6498879
76. Patgiri B, Umretia BL, Vaishnav PU, Prajapati PK, Shukla VJ, Ravishankar B. Anti-inflammatory activity of Guduchi Ghana (aqueous extract of Tinospora Cordifolia Miers.). AYU (An international quarterly journal of research in Ayurveda). 2014 Jan 1;35(1):108-10. https://doi.org/10.4103/0974-8520.141958 PMid:25364210 PMCid:PMC4213960
77. Sindhu G, Ratheesh M, Shyni GL, Nambisan B, Helen A. Anti-inflammatory and antioxidative effects of mucilage of Trigonella foenum graecum (Fenugreek) on adjuvant induced arthritic rats. International immunopharmacology. 2012 Jan 1;12(1):205-11. https://doi.org/10.1016/j.intimp.2011.11.012 PMid:22155102
78. Subramani J, Damodaran A, Kanniappan M, Mathuram LN. Anti-inflammatory effect of petroleum ether extract of Vitex negundo leaves in rat models of acute and subacute inflammation. Pharmaceutical biology. 2009 Apr 1;47(4):335-9. https://doi.org/10.1080/13880200902752660
79. Khan MA, Ahmed RS, Chandra N, Arora VK, Ali A. In vivo, extract from Withania somnifera root ameliorates arthritis via regulation of key immune mediators of inflammation in experimental model of arthritis. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Inflammatory and Anti-Allergy Agents). 2019 Feb 4;18(1):55-70. https://doi.org/10.2174/1871523017666181116092934 PMid:30444203 PMCid:PMC6446523
80. Hosseini A, Alavi MS, Toos MG, Jamialahmadi T, Sahebkar A. 6-Gingerol, an ingredient of Zingiber officinale, abrogates lipopolysaccharide-induced cardiomyocyte injury by reducing oxidative stress and inflammation. Journal of Agriculture and Food Research. 2024 Mar 1;15: 101034. https://doi.org/10.1016/j.jafr.2024.101034
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