Exploring the Versatile Applications of Almond Gum Through Crosslinking Reactions: A Comprehensive Review

Authors

Abstract

Almond gum, a natural polysaccharide obtained from the exudate of Prunus dulcis, is drawing considerable interest due to its inherent biodegradability, biocompatibility, and multifunctional characteristics. As a plant-derived polymer, it offers a sustainable and eco-friendly alternative to synthetic materials in a variety of applications. This review highlights the growing utility of almond gum, particularly focusing on its crosslinking behavior using different agents such as glutaraldehyde, carbodiimides, gelatin, sodium caseinate, polyacrylic acid, and periodate-oxidized sugars. These crosslinking agents significantly enhance the mechanical strength, thermal stability, and water resistance of almond gum-based materials, making them more durable and suitable for practical uses. Such chemically modified forms of almond gum are increasingly used in the pharmaceutical and biomedical sectors, as well as in food processing and environmental applications. Furthermore, the development of polyelectrolyte complexes involving almond gum has opened up promising avenues in advanced drug delivery systems, tissue engineering frameworks, and water purification technologies. These complexes improve the functional versatility of almond gum, allowing it to serve as a carrier, stabilizer, or scaffold in various formulations. Modern research supports the wide-ranging potential of almond gum across disciplines including medicine, agriculture, environmental management, and food science. Its natural origin, combined with its functional adaptability, positions it as a smart and sustainable choice. This review consolidates current advancements and industrial prospects, emphasizing almond gum’s role as a valuable, eco-conscious material for next-generation polymer applications.

Keywords: Natural polysaccharide, Crosslinking agents, Drug delivery, Biocompatibility, Sustainable polymer, Environmental applications, Biomedical applications

Keywords:

Natural polysaccharide, Crosslinking agents, Drug delivery, Biocompatibility, Sustainable polymer, Environmental applications, Biomedical applications

DOI

https://doi.org/10.22270/jddt.v15i6.7170

Author Biographies

Siddhesh Paresh Deshpande , Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur. Maharashtra. India 425405

Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur. Maharashtra. India 425405

Vedant Sunil Chopade , Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur. Maharashtra. India 425405

Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur. Maharashtra. India 425405

Santosh Rajendra Todkar , Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur. Maharashtra. India 425405

Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur. Maharashtra. India 425405

Raju Onkar Sonawane , Associate Professor, Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur. Maharashtra. India 425405

Associate Professor, Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur. Maharashtra. India 425405

References

1. Anand GT, Renuka D, Ramesh R, Anandaraj L, John Sundaram S, Ramalingam G, et al. Green synthesis of ZnO nanoparticle using Prunus dulcis (almond gum) for antimicrobial and supercapacitor applications. Surf Interfaces. 2019;17:100376. https://doi.org/10.1016/j.surfin.2019.100376

2. Bashir M, Haripriya S. Assessment of physical and structural characteristics of almond gum. Int J Biol Macromol. 2016;93:476-82. https://doi.org/10.1016/j.ijbiomac.2016.09.009 PMid:27608543

3. Bostar M, Hosseini E. Improving the functional properties of fish gelatin by conjugation with the water-soluble fraction of bitter almond gum. Korean Soc Food Sci Technol. 2020;2(1):1-9. https://doi.org/10.1007/s10068-020-00847-y PMid:33552617 PMCid:PMC7847419

4. Bouaziz F, Koubaa M, Chaabene M, Barba FJ, Ghorbel RE, Chaabouni SE. High throughput screening for bioactive volatile compounds and polyphenols from almond (Prunus amygdalus) gum: assessment of their antioxidant and antibacterial activities. J Food Process Preserv. 2017;41(4):230-45. https://doi.org/10.1111/jfpp.12996

5. Bouaziz F, Koubaa M, Helbert CB, Kallel F, Driss D, Kacem I, et al. Purification, structural data and biological properties of polysaccharide from Prunus amygdalus gum. Int J Food Sci Technol. 2015;50:578-84. https://doi.org/10.1111/ijfs.12687

6. Bouaziz F, Koubaa M, Jeddou KB, Kallel F, Helbert CB, Khelfa A, et al. Water-soluble polysaccharides and hemicelluloses from almond gum: functional and prebiotic properties. Int J Biol Macromol. 2016;93(Pt A):359-68. https://doi.org/10.1016/j.ijbiomac.2016.08.032 PMid:27527693

7. Chahibakhsh N, Hosseini E, Islam MS, Rahbar AR. Bitter almond gum reduces body mass index, serum triglyceride, hyperinsulinemia and insulin resistance in overweight subjects with hyperlipidemia. J Funct Foods. 2019;55:343-51. https://doi.org/10.1016/j.jff.2019.02.040

8. Chokri S, Ben Younes S, Ellafi A, Mnif S, López-Maldonado EA, Masmoudi AS. Exploring Rhamnus alaternus polysaccharides: Extraction, characterization, and analysis of antioxidant and antimicrobial properties. Korean Soc Food Sci Technol. 2024;16(2):31-80. https://doi.org/10.3390/polym16223180 PMid:39599271 PMCid:PMC11598422

9. Choudhary, Mishra M, Sumit. Silica functionalized almond gum derivatives for integrated flocculation cycles for natural and synthetic water systems. J Polym Environ. 2024;32:1-21. https://doi.org/10.1007/s10924-024-03299-1

10. Cikrikci S, Mert B, Ozlop MH. Development of pH sensitive alginate/gum tragacanth based hydrogels for oral insulin delivery. J Agric Food Chem. 2018;66(44):11784-96. https://doi.org/10.1021/acs.jafc.8b02525 PMid:30346766

11. Dhaka RK, Kumar N, Pratibha, Upadhyay A. Optimization, Characterization, and Influence of Microfluidization on Almond Gum-based Composite Edible Film, Starch Journal, 2021, 73: 1 -10. https://doi.org/10.1002/star.202000101

12. Doost AS, Muhammad DR, Stevens CV, Dewettinck P, Meeren PVR. Fabrication and characterization of quercetin loaded almond gum-shellac nanoparticles prepared by antisolvent precipitation. Food Hydrocoll. 2018;83:190-201. https://doi.org/10.1016/j.foodhyd.2018.04.050

13. Farooq U, Sharma PK, Malviya R. Extraction and characterization of almond (Prunus sulcis) gum as pharmaceutical excipient. Am-Eurasian J Agric Environ Sci. 2014;14(3):269-74.

14. Ghaedi N, Hosseini E. Physical and oxidative stability of emulsions treated with bitter almond gum-soy protein isolate Maillard conjugates. Food Sci Technol. 2021;152:1-10. https://doi.org/10.1016/j.lwt.2021.112352

15. Golkar A, Nasirpour A, Keramat J. Improving the emulsifying properties of β-lactoglobulin-wild almond gum (Amygdalus scoparia Spach) exudate complexes by heat. J Sci Food Agric. 2017;97:341-9. https://doi.org/10.1002/jsfa.7741 PMid:27059005

16. Guo Y, Huang C, Pitcheri R, Shekhar B, Radhalayam D, Roy S, et al. Bio-green synthesis of bismuth oxide nanoparticles using almond gum for enhanced photocatalytic degradation of water pollutants and biocompatibility. Int J Biol Macromol. 2025;300:140222. https://doi.org/10.1016/j.ijbiomac.2025.140222 PMid:39855510

17. Hanumanthappa M, Siddalingappa J, Channabasaveshwara Y, Sundararajan S, Vishwas M, Srinivasaiah S, et al. Almond gum assisted synthesis of Mg doped Fe2O3 NPs: Structural analysis, electrochemical sensing, and optical applications. ChemPhysMater. 2022;1(4):330-7. https://doi.org/10.1016/j.chphma.2022.04.010

18. Hashemi MM, Aminlari M, Forouzan MM, Moghimi E, Tavana M, Shekarforoush S, et al. Production and application of lysozyme-gum Arabic conjugate in mayonnaise as a natural preservative and emulsifier. Pol J Food Nutr Sci. 2018;68:33-43 https://doi.org/10.1515/pjfns-2017-0011

19. Hedayati S, Ansarifar E, Tarahi M, Tahsiri Z, Baeghbali V, Niakousari M. Influence of Persian Gum and Almond Gum on the Physicochemical Properties of Wheat Starch. Gels. 2023 Jun 3;9(6):460. https://doi.org/10.3390/gels9060460 PMid:37367131 PMCid:PMC10297562

20. Hussain A, Jaisankar V. An eco-friendly synthesis, characterisation and antibacterial applications of novel almond gum-poly(acrylamide) based hydrogel silver nanocomposite. Polym Test. 2017;2(1):1-35.

21. Jani GK, Shah DP, Prajapati VD, Jain VC. Gums and mucilages: Versatile excipients for pharmaceutical formulations. Asian J Pharm Sci. 2009;4(5):308-22

22. Kanteti R, Achamma M, Yadav HK, Elmarsafawy TS, Islam Q. Inclusion complexation in sulfobutyl ether beta cyclodextrin and dispersion in Gelucire for sustained release of nifedipine employing almond gum. J Drug Deliv Ther. 2019;9(6):70-8 https://doi.org/10.22270/jddt.v9i6.3681

23. Kanteti R, Sarheed O, Yadav H, Islam Q, Boateng J. Studies on almond gum and Gelucire-based pellets prepared by extrusion and spheronization for sustained release. Turk J Pharm Sci. 2022;19(5):521-9 https://doi.org/10.4274/tjps.galenos.2021.05252 PMid:36317865 PMCid:PMC9634446

24. Kassozi V. Functionality and in-vitro properties of almond gum-shellac nanoparticles fortified with quercetin, Ghent University; 2018, 2: 1 - 12.

25. Kaur N, Pal Y, Bilandi A. Formulation development, optimization, and evaluation of a sustained-release hydrogel system of empagliflozin using almond and neem gums, Cuest.fisioter.2025.54(4):6807-6825.

26. Kono H, Otaka F, Ozaki M. Preparation and characterization of guar gum hydrogels as carrier materials for controlled protein drug delivery. Carbohydr Polym. 2014;111:830-40. https://doi.org/10.1016/j.carbpol.2014.05.050 PMid:25037422

27. Kumar LS, Chitra R, Sumithra M. Investigation of novel biodegradable almond gum - polyvinyl alcohol bi-polymer blend for packaging applications. J Environ Nanotechnol. 2024;13(2):349-54 https://doi.org/10.13074/jent.2024.06.242695

28. Madanakumara H, Jayanna HS, Yelamaggad CV, Soundeswaran S, Vishwas M, Shamala KS, et al. Enhanced electrochemical sensor and photodegradation of industrial wastewater by almond gum assisted synthesis of Bi2O3/MgO/Fe2O3 nanocomposites. Sens Int. 2022;3(1):100193. https://doi.org/10.1016/j.sintl.2022.100193

29. Mahfoudhi N, Chouaibi M, Donsi F, Ferrari G, Hamdi S. Chemical composition and functional properties of gum exudates from the trunk of the almond (Prunus dulcis). Food Sci Technol Int. 2012;18:241-50. https://doi.org/10.1177/1082013211415173 PMid:22701057

30. Mahfoudhi N, Hamdi S. Kinetic degradation and storage stability of carotene encapsulated by freeze-drying using almond gum and gum arabic as wall materials. J Food Process Preserv. 2014 https://doi.org/10.1111/jfpp.12302

31. Mahfoudhi N, Hamdi S. Use of almond gum and gum arabic as novel edible coating to delay postharvest ripening and to maintain sweet cherry (Prunus avium) quality during storage. J Food Process Preserv. 2015;39(6):1499-508. https://doi.org/10.1111/jfpp.12369

32. Malabadi RB, Kolkar KP, Chalannavar RK. Natural plant gum exudates and mucilage: Pharmaceutical updates. Int J Innov Sci Res Rev. 2021;3(10):1897-912

33. Mallikarjuna Gouda M. Formulation and evaluation of colon specific delivery of ciprofloxacin and budesonide tablets using almond gum and Sterculia gum as matrix carriers [thesis]. Rajiv Gandhi University of Health Sciences; 201

34. Mandalari G, Nueno-Palop C, Bisignano G, Wickham MSJ, Narbad A. Potential prebiotic properties of almond (Amygdalus communis L.) seeds. Appl Environ Microbiol. 2008;74:4264-70. https://doi.org/10.1128/AEM.00739-08 PMid:18502914 PMCid:PMC2493170

35. Mirsharifi SM, Sami M, Jazaeri M, Rezaei A. Production, characterization, and antimicrobial activity of almond gum/polyvinyl alcohol/chitosan composite films containing thyme essential oil nanoemulsion for extending the shelf-life of chicken breast fillets. Int J Biol Macromol. 2023;227:405-15 https://doi.org/10.1016/j.ijbiomac.2022.12.183 PMid:36563800

36. Mobin M, Ahmad I, Aslam R, Basik M. Characterization and application of almond gum-silver nanocomposite as an environmentally benign corrosion inhibitor for mild steel in 1 M HCl. Mater Chem Phys. 2022;289:126491 https://doi.org/10.1016/j.matchemphys.2022.126491

37. Najafabadi AP, Pourmadadi M, Yazdian F, Rashedi H, Rahdar A, Díez-Pascual AM. pH-sensitive ameliorated quercetin delivery using graphene oxide nanocarriers coated with potential anticancer gelatin-polyvinylpyrrolidone nanoemulsion with bitter almond oil. J Drug Deliv Sci Technol. 2023;82:104339 https://doi.org/10.1016/j.jddst.2023.104339

38. Ogaji IJ, Nep EI, Audu-Peter JD. Advances in natural polymers as pharmaceutical excipients. Pharm Anal Acta. 2011;3(1):1-16

39. Patel M, Dave K, Patel P. A review on different extraction method of plants: Innovation from ancient to modern technology. Int J Biol Pharm Allied Sci. 2021;10(12):511-27. https://doi.org/10.31032/IJBPAS/2021/10.12.1044

40. Rahimi P, Hosseini E, Rousta E, Bostar H. Digestibility and stability of ultrasound-treated fish oil emulsions prepared by water-soluble bitter almond gum glycated with caseinate. LWT Food Sci Technol. 2021;148:111697. https://doi.org/10.1016/j.lwt.2021.111697

41. Reshma S, Balasasirekha R. Optimisation and development of Aegle marmelos incorporated Prunus amygdalus var dulcis gum capsule film. Int Web Conf Food Technol Nutr. 2021; 35: 31-40. https://doi.org/10.46947/joaasr342021127

42. Rezaei A, Nasirpour A, Tavanai H. Fractionation and some physicochemical properties of almond gum (Amygdalus communis L.) exudates. Food Hydrocoll. 2016;60:461-9 https://doi.org/10.1016/j.foodhyd.2016.04.027

43. Seck M, Diallo A, Erouel M, Saadi M, Tiss B, Wederni M, et al. Dielectric investigation and material properties of almond gum thin films deposited by spray pyrolysis. Mater Chem Phys. 2021;272:124917. https://doi.org/10.1016/j.matchemphys.2021.124917

44. Shinde M, Malik M, Kaur K, Gahlawat VK, Kumar N, Chiraang P, et al. Formulization and characterization of guar gum and almond gum based composite coating and their application for shelf-life extension of okra (Hibiscus esculentus). Int J Biol Macromol. 2024;262(1):129630 https://doi.org/10.1016/j.ijbiomac.2024.129630 PMid:38336319

45. Singh B, Mohan M, Kumar R. Synthesis of hydrocortisone containing dietary fiber almond gum-based hydrogels as sustained drug delivery carriers for use in colon inflammation. Food Hydrocoll Health. 2022;2:100057. https://doi.org/10.1016/j.fhfh.2022.100057

46. Suresh SN, Puspharaj C, Subramani R. Development of almond gum/alginate composites to enhance the shelf-life of post-harvest Solanum lycopersicum L. Food Hydrocoll Health. 2022;2:1-12. https://doi.org/10.1016/j.fhfh.2022.100087

47. Vadivel S, Anusha K, Mounika B, Deepika B. Formulation development and evaluation of olmesartan medoxamil ororetentive jellies. ResGate. 2018.

48. Venkatesan R, Sekar S, Raorane CJ, Raj V, Kim SC. Hydrophilic composites of chitosan with almond gum: Characterization and mechanical, and antimicrobial activity for compostable food packaging. Antibiotics. 2022;11:1502 https://doi.org/10.3390/antibiotics11111502 PMid:36358158 PMCid:PMC9687004

49. Yang M, Peng J, Shi C, Zi Y, Zheng Y, Wang X. Effects of gelatin type and concentration on the preparation and properties of freeze-dried fish oil powders. NPJ Sci Food. 2024;8:9. https://doi.org/10.1038/s41538-024-00251-4 PMid:38307908 PMCid:PMC10837155

50. Zare EN, Makvandi P, Borzacchiello A, Tay FR, Ashtari B, Padil VVT. Antimicrobial gum bio-based nanocomposites and their industrial and biomedical applications. Chem Commun. 2019;55:14871-85. https://doi.org/10.1039/C9CC08207G PMid:31776528

Published

2025-06-15
Statistics
Abstract Display: 645
PDF Downloads: 750
PDF Downloads: 132

How to Cite

1.
Deshpande SP, Chopade VS, Todkar SR, Sonawane RO. Exploring the Versatile Applications of Almond Gum Through Crosslinking Reactions: A Comprehensive Review. J. Drug Delivery Ther. [Internet]. 2025 Jun. 15 [cited 2026 Feb. 2];15(6):219-28. Available from: https://www.jddtonline.info/index.php/jddt/article/view/7170

How to Cite

1.
Deshpande SP, Chopade VS, Todkar SR, Sonawane RO. Exploring the Versatile Applications of Almond Gum Through Crosslinking Reactions: A Comprehensive Review. J. Drug Delivery Ther. [Internet]. 2025 Jun. 15 [cited 2026 Feb. 2];15(6):219-28. Available from: https://www.jddtonline.info/index.php/jddt/article/view/7170

Most read articles by the same author(s)