Formulation and Evaluation of Sustained release tablet of Trazodone hydrochloride by using Synthetic Polymer RS100 and RL 100
Abstract
Sustained release tablet was prepared by wet granulation method using synthetic polymer RS 100 and RL 100. The prepared tablet was also evaluated for their diameter, thickness, drug content, Hardness, friability, weight variation. The thickness and diameter of tablet ranges from 5.43 ±0.288 to 5.76 ±0.05 and 09.68±0.577 to 10.04 ±0.04 respectively. Drug content was studied and its ranges from 92.03 to 98.60 %. Hardness was studied its ranges 5.5 to 6.5 kg/cm2, Friability ranges 0.71 to 0.95%, Weight variation ranges between 434±1.49 to 460±1.23. FTIR and DSC analysis does not show any interaction of drug with Excipients. Formulation was optimized on the basis of acceptable pre and post compressional parameters. The results of dissolution studies indicated that Batch F4 exhibited drug release of 88.06% at the end of 12 hr. to provide sufficient concentration for achieving satisfactory therapeutic value for extended period of time. The drug release from Batch F4 formulation was sustained 12hr. Fitting in-vitro drug release data from optimized matrix formulation to zero order followed by Higuchi model indicated that diffusion could be mechanism of drug release. The n value indicates a non – fiction or anomalous diffusion pattern. This means that both the diffusion and erosion mechanism were prevalent.
Keywords: Trazodone hydrochloride, Wet granulation, RS100, RL100, sustained release.
Keywords:
Trazodone Hydrochoride, Wet granulation, Sustained released, RS100, RL100DOI
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