The HepG2 cells growth inhibitory capacity from the leaves of Peristrophe bivalvis (L.) Merr. a natural dye in food culture
Abstract
There is increasing interest in medicinal use of Peristrophe bivalvis (L.) Merr (PM) in traditional medicine practical applications. The in vitro HepG2 cells growth inhibitory capacity from ethanol 70% extract (E70) of the leaves of Peristrophe bivalvis (L.) Merr was firstly investigated. The results indicated that E70 extract inhibited the proliferation of HepG2 cells. When the effect of E70 on intracellular signaling was measured, E70 stimulated the apoptotic factors bax, caspase-3 and caspase-9 in HepG2 cells. The results demonstrated that E70 induces programmed cell death (apoptosis) in HepG2 cells. The further research to determine pharmacokinetics of the main components, the definitve mechanism and clinical trial should be caried out more to firm evidence.
Keywords: Peristrophe bivalvis (L.) Merr, natural dyes, food coloring, HepG2.
Keywords:
Peristrophe bivalvis (L.) Merr, natural dyes, food coloring, HepG2DOI
https://doi.org/10.22270/jddt.v15i5.7153References
1. Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochemical pharmacology 2006; 71(10): 1397-1421. https://doi.org/10.1016/j.bcp.2006.02.009 PMid:16563357
2. Aluko EO, David UE, Ojetola AA, Fasanmade AA. Aqueous extract of Peristrophe bivalvis (L.) Merr. leaf reversed the detrimental effects of nitric oxide synthase inhibitor on blood lipid profile and glucose level. Plos one 2024; 19(9): e0308338. https://doi.org/10.1371/journal.pone.0308338 PMid:39240961 PMCid:PMC11379291
3. Anantharaman A, Subramanian B, Chandrasekaran R, Seenivasan R, Siva R. Colorants and cancer: a review. Industrial Crops and Products 2014; 53: 167-186. https://doi.org/10.1016/j.indcrop.2013.12.025
4. Kumar JK, Sinha AK. Resurgence of natural colourants: A holistic view. Natural Product Letters 2004; 18: 59-84. https://doi.org/10.1080/1057563031000122112 PMid:14974619
5. Le PH, Dao DN, Huynh TQ, Tran TT, Nguyen V. Extraction and purification of anthocyanins from Peristrophe bivalvis (L.) Merr. leaf (Acanthaceae) using aqueous two-phase systems. Natural Product Research 2023, 37(1): 154-158. https://doi.org/10.1080/14786419.2021.1952203 PMid:34254860
6. Le QU, Lay HL, Wu MC. The isolation, structural characterization, and anticancer activity from the aerial parts of Cymbopogon flexuosus. Journal of food biochemistry 2019; 43(2): e12718. https://doi.org/10.1111/jfbc.12718 PMid:31353668
7. Le QU, Lay HL, Wu MC, Nguyen THH. Natural plant colorants widely used in Vietnam traditional food culture. Journal of Food, Nutrition and Agriculture 2018; 1(1): 40-46. https://doi.org/10.21839/jfna.2018.v1i1.220
8. Le, QU, Lay HL, Wu MC. Antioxidant activities and HepG2 cells growth inhibitory capacity of whole plant ethanol extracts (Eclipta alba Hassk and Mesona procumbens Hemsl). Journal of Food Biochemistry 2018; 42(2): e12454. https://doi.org/10.1111/jfbc.12454
9. Pawlowski J, Kraft AS. Bax-induced apoptotic cell death. Proceedings of the National Academy of Sciences 2000; 97(2): 529-531. https://doi.org/10.1073/pnas.97.2.529 PMid:10639111 PMCid:PMC33959
10. Phaopongthai J, Noiphrom J, Phaopongthai S, Pakmanee N, Sichaem J. Biological activities of Peristrophe bivalvis extracts: promising potential for anti-snake venoms against Naja kaouthia and Trimeresurus albolabris venoms. Natural Product Research 2016; 30(6): 697-699. https://doi.org/10.1080/14786419.2015.1038810 PMid:25942501
11. Trinh TT, Tran HL, Tran HL, Nguyen TTH, Le THN, Pham TN, Nguyen THA, Tran TPT, Tran VS. Natural phenoxazine alkaloids from Peristrophe bivalvis (L.) Merr. Biochemical Systematics and Ecology 2012; 44: 205. https://doi.org/10.1016/j.bse.2012.05.009
12. Wood DE, Newcomb EW (2000). Cleavage of Bax enhances its cell death function. Experimental cell research 2000; 256(2): 375-382. https://doi.org/10.1006/excr.2000.4859 PMid:10772810
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