Why do they use bhat chew sticks? An experiment to demonstrate the antihyperglycemic activity of Clerodendrum infortunatum Linn.
Abstract
Introduction: The rise in blood glucose than the recommended level is called hyperglycemia, mainly caused by diabetes mellitus (DM). DM is in turn a consequence of decreased insulin secretion or action or both. This experiment is intended to evaluate the effect of Clerodendrum infortunatum Linn. (bhat) chew sticks in controlling diabetes in humans. Method: The fasting blood sugar was measured twice with the help of a glucometer. First, all participants were requested to measure their blood sugar on an empty stomach in the morning without using a bhat chew stick. The next morning, their fasting plasma sugar was again accessed after the use of the bhat chew sticks as a toothbrush. The fall in blood sugar value was recorded and the efficiency of the stimulus was tested using student t-test at α level of significance and n-1 degree of freedom. Result: A total of 27 individuals participated in the study and all responded to the stimulus. A fall in blood glucose was observed between 3-59 mg/dL and the response was not found to be significant at 0.05 level of significance. Conclusion: Rural people use chew sticks as toothbrushes and prefer C. infortunatum twigs to control diabetes. The present experiment shows that bhat lowers the blood sugar level in both diabetic and non-diabetic individuals. However, chronic impacts should also be monitored by conducting large-scale studies on humans to establish proper dosage, indications, and side effects of C. infortunatum.
Keywords: Clerodendrum infortunatum, diabetes, hyperglycemia, random blood sugar, chew stick.
Keywords:
Clerodendrum infortunatum, diabetes, hyperglycemia, random blood sugar, chewstickDOI
https://doi.org/10.22270/jddt.v14i12.6902References
1. Holesh JE, Aslam S, Martin A, Physiology, Carbohydrates, StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2023. [PubMed] PMID: 29083823 Bookshelf ID: NBK459280
2. Mouri MI, Badireddy M, Hyperglycemia, StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430900/
3. Hammer M, Storey S, Hershey DS, Brady VJ, Davis E, Mandolfo N, Bryant AL, Olausson J, Hyperglycemia and Cancer: A State-of-the-Science Review, Oncol Nurs Forum, 2019; 01; 46(4):459-472. [PubMed] [Reference list]
4. Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT, Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy, Lancet, 2012; 380 (9838): 219–229. doi:10.1016/S0140-6736(12)61031-9. PMC 3645500. PMID 22818936.
5. Ma RCW, Popkin BM, Intergenerational diabetes and obesity—A cycle to break? PLoS Med, 2017; 14(10): e1002415. doi:10.1371/journal.pmed.1002415. PMC 5663330. PMID 29088227.
6. American Diabetes Association, Diagnosis and Classification of Diabetes Mellitus, Diabetes Care, 2014; 37: S81–S90. doi:10.2337/dc14-s081. PMID 24357215.
7. Yari Z, Behrouz V, Zand H, Pourvali K, New Insight into Diabetes Management: From Glycemic Index to Dietary Insulin Index, Curr Diabetes Rev, 2020; 16(4): 293-300. https://doi.org/10.2174/1573399815666190614122626 [PubMed] [Reference list]
8. Simon K, Wittmann I, Can blood glucose value really be referred to as a metabolic parameter? Rev Endocr Metab Disord, 2019; 20(2): 151-160. https://doi.org/10.1007/s11154-019-09504-0 [PMC free article] [PubMed] [Reference list]
9. Duncan AE, Hyperglycemia and Perioperative Glucose Management, Current Pharmaceutical Design, 2012; 18 (38): 6195-6203. doi:10.2174/138161212803832236. PMC 3641560. PMID 22762467.
10. Antar SA, Ashour NA, Sharaky M, Khattab M, Ashour NA, Zaid RT, Roh EJ, Elkamhawy A, Al-Karmalawy AA, Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments, Biomedicine & Pharmacotherapy, 2023; 168: 115734. https://doi.org/10.1016/j.biopha.2023.115734.
11. Reddy SSK, Tan M, Chapter 1 - Diabetes mellitus and its many complications. In: Tan M, editor. Diabetes Mellitus: Impact on Bone, Dental and Musculoskeletal Health, Academic Press, 2020; (pp. 1-18). https://doi.org/10.1016/B978-0-12-820605-8.00001-2
12. Poznyak A, Grechko AV, Poggio P, Myasoedova VA, Alfieri V, Orekhov AN, The diabetes mellitus–atherosclerosis connection: The role of lipid and glucose metabolism and chronic inflammation, Int. J. Mol. Sci., 2020; 21 (5): 1835. DOI: 10.3390/ijms21051835
13. American Diabetes Association, Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes, Diabetes Care, 2019; 42 (Suppl 1): S13–S28. doi:10.2337/dc19-S002. PMID 30559228. S2CID 56176183.
14. The Lancets, Diabetes: a defining disease of the 21st century, EDITORIAL, June 24, 2023; Volume 401, Issue 10394, P2087 DOI: 10.1016/S0140-6736(23)01296-5
15. Kaul K, Tarr JM, Ahmad SI, Kohner EM, Chibber R, Introduction to Diabetes Mellitus. In: Ahmad, SI (eds), Diabetes. Advances in Experimental Medicine and Biology, 2013; 771:1-11. https://doi.org/10.1007/978-1-4614-5441-0_1
16. Nimesh S, Toamr R, Dhiman S, Medicinal Herbal Plants and Allopathic Drugs to Treat Diabetes Mellitus: A glance, Adv Pharmacol Clin Trials, 2019; 4(1): 000150. DOI: https://doi.org/10.23880/apct-16000151
17. Umpierrez GE, Hellman R, Korytkowski MT, et al., Management of hyperglycemia in hospitalized patients in non-critical care setting: an Endocrine Society clinical practice guideline, J Clin Endocrinol Metab, 2012; 97(1): 16-38. https://doi.org/10.1210/jc.2011-2098 PubMed Google Scholar
18. Bhattacharjee D, Das A, Das S, Chakraborthy G, Clerodendrum Infortunatum Linn. : A Review, Journal of Advances in Pharmacy and Healthcare Research, 2011; 1(3): 82-85. Researchgate
19. Gera NB, Darshani PP, Chemical composition of a volatile fraction from the leaves of Clerodendrum infortunatum L., Nat. Prod. Res., 2022; 36(3): 853–856. https://doi.org/10.1080/14786419.2020.1805602
20. Nandi S, Lyndem LM, Clerodendrum viscosum: traditional uses, pharmacological activities and phytochemical constituents, Nat. Prod. Res., 2016; 30(5): 497–506. https://doi.org/10.1080/14786419.2015.1025229
21. Ogunlakin AD, Akinwumi I.A, Ambali OA, Ethnomedicinal application, phytochemistry and therapeutic effects of genus Clerodendrum, Functional Food Science, 2023; 3(10): 228-247. DOI http://dx.doi.org/10.31989/ffs.v3i10.1151
22. Prashith TR, Shree VS, Noorain GK, Sahana BK, Raghavendra HL, Ethnobotanical uses, phytochemistry and pharmacological activities of Clerodendrum infortunatum L. (Lamiaceae): A review, Journal of Drug Delivery and Therapeutics, 2019; 9(2): 547-559. http://dx.doi.org/10.22270/jddt.v9i2.2433
23. Sharma HK., Chhangte L, Dolui AK, Traditional medicinal plants in Mizoram, India, Fitoterapia, 2001; 72 (2): 146–161. doi:10.1016/S0367-326X(00)00278-1. PMID 11223224.
24. Rahman AU, Zaman K, Medicinal plants with hypoglycemic activity, J Ethnopharmacol, 1989; 26 (1): 1–55. doi:10.1016/0378-8741(89)90112-8. PMID 2664356.
25. Das S, Bhattacharya S, Prasanna A, Suresh Kumar RB., Pramanik G, Haldar PK, Preclinical evaluation of antihyperglycemic activity of Clerodendron infortunatum leaf against streptozotocin-induced diabetic rats, Diabetes Ther, 2011; 2(2): 92-100. https://doi.org/10.1007%2Fs13300-010-0019-z
26. Baid SS, Evaluation of Antihyperglycemic and Hypolipidemic Activities of Clerodendrumn infortunatum Linn. Leaf Extracts, Asian Journal of Complementary and Alternative Medicine, 2013; 01 (01): 01-08. Source: Asian Journal of Complementary and Alternative Medicine
27. Yasmeen AM, Roopa CR, Janaki Devi CH, (2015). Evaluation of antihyperglycemic and hypolipidemic activity of ethanolic extract of Clerodendrum infortunatum Linn. in experimental animals, International Journal of Basic and Clinical Pharmacology, 2015; 4(3): 469-473. http://dx.doi.org/10.18203/2319-2003.ijbcp20150019
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