Anti-epileptic activity of casticin phytoconstituent from Vitex negundo on validated animal model
Abstract
This study investigates the antiepileptic potential of the methanolic extract of Vitex negundo leaves in seizure models induced in mice using lithium-pilocarpine, maximal electroshock (MES), strychnine, picrotoxin, and pentylenetetrazol. The extract demonstrated a protective effect against seizures induced by MES and enhanced the efficacy of standard anticonvulsant drugs against chemically-induced seizures. The results suggest that the flavonoids present in the methanolic extract may exert their antiepileptic effects by modulating GABAergic pathways and blocking sodium (Na⁺) channels in a dose-dependent manner. These findings highlight the potential of Vitex negundo methanolic extract as a promising therapeutic candidate for epilepsy treatment.
Keywords: Vitex negundo, methanolic extract, maximal electroshock (MES), antiepileptic, animal models, GABAergic pathway
Keywords:
Vitex negundo, methanolic extract, MES, electroclinicalDOI
https://doi.org/10.22270/jddt.v14i12.6859References
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