Chemotherapeutic Agents in Periodontics: A Review
CHEMOTHERAPEUTIC AGENTS IN PERIODONTICS
Abstract
"Selman Waksman" first used the term "antibiotic" in 1942 to refer to any material produced by a bacterium that inhibits the growth of other micro-organisms in high dilution. The pathogenic bacteria, the patient, and the medication are the three main components of the antibiotic periodontal therapy idea. Patients with attachment loss or with aggressive types of periodontitis or those with periodontitis linked with underlying medical conditions are the best candidates for systemic antimicrobial therapy. The three main objectives of Periodontal Therapy are disrupting biofilms, suppressing potential periodontal pathogens throughout the entire oral cavity, and halting the illness. The microbial etiology of inflammatory periodontal disease provides the rationale for the use of antibiotic medication in periodontal therapy. This idea is predicated on the idea that a certain bacterium causes destructive periodontal disease and that antibiotic agents can be present in humans in doses greater than those required to kill or inhibit infections.
Keywords: Antibiotics, Systemic drug delivery, Local drug delivery, Periodontal therapy.
Keywords:
Antibiotics, Systemic drug delivery, Local drug delivery, Periodontal therapyDOI
https://doi.org/10.22270/jddt.v14i5.6610References
Kaur L, Kaushik M, Singh S, Arora G. Evaluation of healing and anti-plaque efficacy of antioxidant mouthrinse in patients with gingival inflammation. Int J Oral Health Dent 2021;7:14-19. https://doi.org/10.18231/j.ijohd.2021.004
Gould K. Antibiotics: from prehistory to the present day. J Antimicrob Chemother 2016;71:572-575. https://doi.org/10.1093/jac/dkv484 PMid:26851273
Slots J, Ting M. Systemic antibiotics in the treatment of periodontal disease. Periodontol 2000 2002;28:106-116. https://doi.org/10.1034/j.1600-0757.2002.280106.x PMid:12013339
Kapoor A, Malhotra R, Grover V, Grover D. Systemic antibiotic therapy in periodontics. Dent Res J 2012;9:505-515. https://doi.org/10.4103/1735-3327.104866 PMid:23559912 PMCid:PMC3612184
Caton JG, Ciancio SG, Blieden TM, Bradshaw M, Crout RJ, Hefti AF, et al. Sub antimicrobial dose doxycycline as an adjunct to scaling and root planing: post-treatment effects. J Clin Periodontol 2001;28:782-789. https://doi.org/10.1034/j.1600-051X.2001.280810.x PMid:11442739
Paterson L, David J, Stuart K. Looking for risk factors for the acquisition of antibiotic resistance: a 21st century approach. Clinical infectious diseases 2002;34:1564-1567. https://doi.org/10.1086/340532 PMid:12032890
Heitz-Mayfield LJ. Systemic antibiotics in periodontal therapy. Aust Dent J, 2009;54:96-101. https://doi.org/10.1111/j.1834-7819.2009.01147.x PMid:19737272
Newman, Takei, Klokkevold, Carranza. Carranza's Clinical Periodontology. 10th edition. 2006.
Dannewitz B, Lippert K, Lang NP, Tonetti MS, Eickholz P. Supportive periodontal therapy of furcation sites: non-surgical instrumentation with or without topical doxycycline. J Clin Periodontol 2009;36:514-522. https://doi.org/10.1111/j.1600-051X.2009.01414.x PMid:19508250
Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis. J Periodontol 2009;80:364-371. https://doi.org/10.1902/jop.2009.080540 PMid:19254119
Yashima A, Gomi K, Maeda N, Arai T. One stage full-mouth versus partial-mouth scaling and root planning during the effective half-life of systemically administered azithromycin. J Periodontol 2009;80:1406-1413. https://doi.org/10.1902/jop.2009.090067 PMid:19722790
Dannewitz B, Pohl S, Eickholz P, Kim TS. Clinical and microbiological effects of a combined mechanic-antibiotic therapy in subjects with Actinobacillus actinomycetemcomitans-associated periodontitis Am J Dent 2007;20:153-156.
Goodson JM, Cugini MA, Kent RL, Armitage GC, Cobb CM, Fine D, et al. Multicenter evaluation of tetracycline fibre therapy: II. Clinical response. J Periodontal Res 1991;26:371-379. https://doi.org/10.1111/j.1600-0765.1991.tb02076.x PMid:1831505
Singh P, Rana N, Kaushik M, Singh S. Role of antioxidants in Periodontal therapy. Int J Sci Res 2022;11:1-3.
Awartani FA, Zulqarnain BJ. Comparison of the clinical effects of subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis. Quintessence Int 1998;29:41-48.
Manini, Agarwal M, Kaushik M, Tomar N. Root Biomodification. J App Sci Comp 2020;7:230-238
Published
Abstract Display: 355 
PDF Downloads: 720 PDF Downloads: 31 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.