A Systematic Review on Comparison of Deep Brain Stimulation (DBS) and Transcranial Magnetic Stimulation (TMS) in the Treatment of Refractory Obsessive Compulsive Disorder (OCD)

Authors

  • K Dhivya Assistant Professor, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, 600097, India https://orcid.org/0009-0002-7789-990X
  • Bibila Samuel Pharm D Student, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, 600097, India

Abstract

The Diagnostic and Statistical Manual of mental disorders (DSM 4) defines obsessive compulsive disorder (OCD) as compulsive or repetitive behaviors of obsessions that a person feels driven to perform. These acts and behaviors are aimed at preventing or reducing distress but are not connected in a realistic way. OCD is a pathological hypothesis of dysfunctions occurring within the cortico-striato-thalamo-cortical loops. It is one of the most prevalent and disabling psychiatric disorder associated with decreased life quality (American Psychiatric Association). This article will provide a brief study on the comparison of deep brain stimulation and transcranial magnetic stimulation in the treatment of refractory obsessive compulsive disorder besides other pharmacological and non-pharmacological treatments.

Keywords: OCD, Deep brain stimulation, Transcranial magnetic stimulation

Keywords:

Obsessive compulsive disorder (OCD), Treatment of OCD, Deep brain stimulation, Transcranial mag stimulation

DOI

https://doi.org/10.22270/jddt.v13i7.6126

Author Biographies

K Dhivya, Assistant Professor, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, 600097, India

Assistant Professor, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, 600097, India

Bibila Samuel, Pharm D Student, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, 600097, India

Pharm D Student, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai, 600097, India

References

Sannekede HS, Rietveld E, Stokhof M, Denys D. The phenomenology of deep brain stimulation induced changes in obsessive-compulsive disorder: an enactive affordance-based model. Frontiers in human neuroscience 2013; 7:1-14. https://doi.org/10.3389/fnhum.2013.00653

Schleyken S, Baldermann J, Huys D, Franklin J, Vandewalle V, Kuhn J, et al. Deep brain stimulation and sensorimotor gating in tourette syndrome and obsessive-compulsive disorder. Journal of psychiatric research 2020; 129:272-280. https://doi.org/10.1016/j.jpsychires.2020.07.016

Mohammad H, Shayganfard M, Jahangard L, Ahmadpanah M, Bajoghli H, Pirdehghan A, et al. Repetitive transcranial magnetic stimulation improves symptoms and reduces clinical illness in patients suffering from obsessive-compulsive disorder results from a single-blind, randomized clinical trial with sham cross-over condition. Journal of psychiatric research 2015: 238-244. https://doi.org/10.1016/j.jpsychires.2015.06.020

Sarah MF, Guzick AG, Reid AM, Mason DM, Bertone A, Foote KD, et al. Six-Nine follow up of deep brain stimulation for obsessive-compulsive disorder. Public library of science one 2016; 1-11. https://doi.org/10.1371/journal.pone.0167875

Ihtsham UH, Foote KD, Goodman WG, Wu SS, Sudhyadhom A, Ricciuti N, et al. Smile and laughter induction and intraoperative predictors of response to deep brain stimulation for obsessive-compulsive disorder. Neuroimage 2011; 54:S247-S255. https://doi.org/10.1016/j.neuroimage.2010.03.009

James LA, Curtis GC, Sagher O, Albucher RC, Harrigan M, Taylor SF, et al. Deep brain stimulation for refractory obsessive-compulsive disorder. Bliolpsychiatry 2005; 57:510-516.6. https://doi.org/10.1016/j.biopsych.2004.11.042

Kohl S, Gruendler TO, Huys D, Sildatke E, Dembek TA, Hellmich M, et al. Effect of deep brain stimulation on prepulse inhibition in obsessive-compulsive disorder. Translational psychiatry 2015; 5:1-6. https://doi.org/10.1038/tp.2015.171

De Koning, Figee M, Endert E, Van Den Munckhof P, Schuurman PR, Storosum JG, et al. Rapid effects of deep brain stimulation reactivation of symptoms and neuroendocrine parameters in obsessive-compulsive disorder. Translational psychiatry 2016; 6:1-4. https://doi.org/10.1038/tp.2015.222

Isidoor OB, Mantione M, Hoogendoorn ML, Denys D. Cognitive functioning in psychiatric disorder following deep brain stimulation. Brain stimulation 2013; 6:532-537. https://doi.org/10.1016/j.brs.2013.01.003

Maarten BW, Rietveld E, Bergfeld IO, De Koning P, Vullink N, Ooms P, et al. Optimizing deep brain stimulation in obsessive-compulsive disorder. Neuromodulation: Technology at the Neural Interface. 2021; 24(2):307-15. https://doi.org/10.1111/ner.13243

Donald AM, Greenberg BD, Rezai AR. The use of deep brain stimulation in psychiatric disorders. Clinical neuroscience research 2004; 4:107-112. https://doi.org/10.1016/j.cnr.2004.06.010

Sanneke DH, Rietveld E, Stokhof M, Denys D. Effects of deep brain stimulation on the lived experience of obsessive-compulsive disorder patients: In-depth interviews with 18 patients. Public library of science one 2015: 1-29.

Marshall T, Holland, Nicholas TT, Laurie MM, Francis JJ, Mario Zanaty, Liesl NC, et al. Deep brain stimulation for obsessive-compulsive disorder: A long term naturalistic follow-up study in single institution. Frontiers in psychiatry 2020; 11:1-14. https://doi.org/10.3389/fpsyt.2020.00055

Benjamin DG, Malone DA, Friehs GM, Rezai AR, Kubu CS, Malloy PF, et al. Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder. Neuropsychopharmacology 2006; 31:2384-2393. https://doi.org/10.1038/sj.npp.1301165

Matione M, Nieman DH, Figee M, Denys D. Cognitive-behavioral therapy augments the effects of deep brain stimulation in obsessive-compulsive disorder. Psychological medicine 2014; 44:3515-3522. https://doi.org/10.1017/S0033291714000956

Pieter O, Mantione M, Martijn Figee, Richard SP, Van Den Munckhof P, Damiaan D. Deep brain stimulation for obsessive-compulsive disorder: long-term analysis of quality of life. Neuropsychiatry 2015; 0:1-6.

Damiaan D, Mantione M, Figee M, Van Den Munckhof P, Koerselman F, Westenberg H, et al. Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. Arch gen psychiatry 2010; 67:1061-1068. https://doi.org/10.1001/archgenpsychiatry.2010.122

Pieter Ooms, Blankers M, Figee M, Mantione M, van den Munckhof P, Schuurman PR, et al. Rebound of affective symptoms following acute cessation of deep brain stimulation in obsessive-compulsive disorder. Brain stimulation 2014; 7:727-731. https://doi.org/10.1016/j.brs.2014.06.009

Matione M, Nieman D, Figee M, van den Munckhof P, Schuurman R, Denys D. Cognitive effects of deep brain stimulation in patients with obsessive-compulsive disorder. Psychiatry Neurosci 2015; 40: 378-386. https://doi.org/10.1503/jpn.140210

Yiftach Roth, Barnea YN, Carmi L, Storch EA, Tendler A, Zangen A. Deep transcranial magnetic stimulation for obsessive-compulsive disorder is efficacious even in patients who failed multiple medications and cognitive behavioral therapy. Psychiatric research 2020: 01651781.

Saurabh K, Singh S, Chadda RK, Verma R, Kumar N. The effect of low frequency repetitive transcranial stimulation at orbitofrontal cortex in the treatment of patients with medicationrefractory obsessive-compulsive disorder. Journal of electroconvulsive therapy; 00.

Emily RH, Dilkov D, Kaludiev E, Simek S, Zhang F, Milev R. Transcranial magnetic stimulation of supplementary motor area in the treatment of obsessive-compulsive disorder: A multi-site study. International journal of molecular science 2016; 17:420: 1-10. https://doi.org/10.3390/ijms17030420

Lana Donse, Sack AT, Fitzgerald PB, Arns M. Sleep disturbance in obsessive-compulsive disorder: Association with non-response to repetitive transcranial magnetic stimulations. Journal of anxiety disorder 2017; 49:31-39. https://doi.org/10.1016/j.janxdis.2017.03.006

Mandana M, Meek BP, Sareen J, Enns MW. Impaired trial-by-trial adjustment of cognitive control in obsessive compulsive disorder improves after deep repetitive transcranial magnetic stimulation. Biomed central neuroscience 2015; 16:63:1-9. https://doi.org/10.1186/s12868-015-0205-z

Arumugham SS, Subhasini VS, Madhuri HN, Vinay B, Ravi M, Sharma E, et al. Augmentation effect of low-frequency repetitive transcranial magnetic stimulation over presupplementary motor area in obsessive-compulsive disorder. Journal of electroconvulsive therapy 2018; 00:15. https://doi.org/10.1097/YCT.0000000000000509

Reza R, Kazemi R, Jabbari A, Madani AS, Rostami H, Taherpour M, et al. Efficacy and clinical predictors of response to repetitive transcranial magnetic stimulation treatment in pharmacoresistant obsessive-compulsive disorder: a retrospective study. Biomed central psychiatry 2020; 20: 372:1-13. https://doi.org/10.1186/s12888-020-02769-9

Pablo Vinicius OG, Brasil Neto JP, Allam N, Rodrigues de SE. A randomized, double-blind trial of repetitive transcranial magnetic stimulation in obsessive-compulsive disorder with three month follow up. The journal of neuropsychiatry and clinical neurosciences 2012; 24:437-443. https://doi.org/10.1176/appi.neuropsych.11100242

Lior Carmi, Tendler A, Bystritsky A, Hollander E, Blumberger DM, Daskalakis J, et al. Efficacy and safety of deep transcranial magnetic stimulation for obsessive-compulsive disorder: A prospect multicenter randomized double-blind placebo-controlled trial. Journal of psychiatry in advance 2019; 1-8. https://doi.org/10.1176/appi.ajp.2019.18101180

Antonio M, Simpson HB, Fallon BA, Rossi S, Lisanby SH. Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. International journal of neuropsychopharmacology 2010; 13:217-227. https://doi.org/10.1017/S1461145709990435

Remy B, Mondino M, Le Camus F, Saoud M, Brunelin J. Transcranial direct current stimulation in patients with obsessive-compulsive disorder: A randomized controlled trial. European psychiatry 2019; 62:38-44. https://doi.org/10.1016/j.eurpsy.2019.08.011

Published

2023-07-15
Statistics
Abstract Display: 503
PDF Downloads: 531
PDF Downloads: 163

How to Cite

1.
Dhivya K, Samuel B. A Systematic Review on Comparison of Deep Brain Stimulation (DBS) and Transcranial Magnetic Stimulation (TMS) in the Treatment of Refractory Obsessive Compulsive Disorder (OCD). J. Drug Delivery Ther. [Internet]. 2023 Jul. 15 [cited 2026 Feb. 2];13(7):161-7. Available from: https://www.jddtonline.info/index.php/jddt/article/view/6126

How to Cite

1.
Dhivya K, Samuel B. A Systematic Review on Comparison of Deep Brain Stimulation (DBS) and Transcranial Magnetic Stimulation (TMS) in the Treatment of Refractory Obsessive Compulsive Disorder (OCD). J. Drug Delivery Ther. [Internet]. 2023 Jul. 15 [cited 2026 Feb. 2];13(7):161-7. Available from: https://www.jddtonline.info/index.php/jddt/article/view/6126