Express method for particle size analysis in solid, liquid, and amorphous materials using 3D calibration curve and 2D-DLS dynamic light scattering

Authors

  • Ekaterina Kolyabina Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
  • Tatyana Maksimova Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
  • Anton Syroeshkin Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

Abstract

This study proposes a new method for particle size studying based on the use of topological descriptors for various media and types of matter. The sizes of supramolecular particles in water-lactose complexes were studied using the diffuse dynamic light scattering (DLS) method. Mist-Standart latex balls were used to generate a 3D calibration curve, followed by empirical particle size determination. In order to confirm the output, the resulting sizes were compared for a number of silver proteinate solutions, preliminary analyzed by laser light scattering (using ZetaSizer equipment by Malvern Instruments Ltd, UK). The new method uses a simplified procedure, provides a quick solution and may be used for both quality control of cloudy and opaque medicinal substances and excipients as well as in other fields of nanotechnology.

Keywords: nanoparticles, particle size, silver proteinate, latex nanoparticles, dynamic light scattering

Keywords:

nanoparticles, particle size, silver proteinate, latex nanoparticles, dynamic light scattering

DOI

https://doi.org/10.22270/jddt.v13i4.6029

Author Biographies

Ekaterina Kolyabina, Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

Tatyana Maksimova, Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

Anton Syroeshkin, Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation

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Published

2023-04-15
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How to Cite

1.
Kolyabina E, Maksimova T, Syroeshkin A. Express method for particle size analysis in solid, liquid, and amorphous materials using 3D calibration curve and 2D-DLS dynamic light scattering. J. Drug Delivery Ther. [Internet]. 2023 Apr. 15 [cited 2026 Jan. 30];13(4):9-12. Available from: https://www.jddtonline.info/index.php/jddt/article/view/6029

How to Cite

1.
Kolyabina E, Maksimova T, Syroeshkin A. Express method for particle size analysis in solid, liquid, and amorphous materials using 3D calibration curve and 2D-DLS dynamic light scattering. J. Drug Delivery Ther. [Internet]. 2023 Apr. 15 [cited 2026 Jan. 30];13(4):9-12. Available from: https://www.jddtonline.info/index.php/jddt/article/view/6029

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