Prophylactic aspects and therapeutic potential of Turbud (Operculina turpethum L) in Unani medicine: An evidence-based appraisal
Abstract
Abstract
Turbud (Operculina turpethum L.) belongs to the family Convolvulaceae, a potent and well-known medicinal herb, used in Unani system of medicine to treat several diseases. It is a large perennial twinner with milky juice. Roots are long, slender, fleshy, and much branched. In classical text it is mentioned that the Turbud which is white in colour, light weighted and having resin on both ends is of good quality. In Unani system of medicine, its main actions are expectorant and laxative and used in several diseases like arthritis, ascites, gout, hemiplegia etc. According to Ibn Sina use of Turbud along with zanjabeel is more effective. It has been used as an important component in many compound formulations such as Itrifal Ustu-khud’dus, Itrifal Zamani, Itrifal Muqil, Itrifal Mulaiyyin. The major chemical constituents present are turpethin, glucoside, jalapine, convolvulin etc. Operculina turpethum L. is validated for its different pharmacological actions like anti-inflammatory effect, and ulcer protective etc. The present review comprehensively embodied its phytochemical, pharmacological and pharmacognostic description.
Keywords:
Turbud, convolvulin, turpethin, traditional medicine, UnaniDOI
https://doi.org/10.22270/jddt.v13i2.5947References
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19. Khare AK. A preliminary study of anti-inflammatory activity of Ipomoea turpethum (Nisoth). Indian Drugs. 1982.
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21. Prabhavati NB, Kowsalya B, Kumar SR, Sravani BJ, Sri GD, Sakila A et al. Analgesic activity of different solvent extract of Operculina turpethum by using swiss albino mice. Asian Journal of Pharmaceutical and Clinical Research. 2012; 5(3):215-218.
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26. Shareef H, Rizwani GH, Mandukhail SR, Watanabe N, Gilani AH. Studies on antidiarrhoeal, antispasmodic and bronchodilator activities of Operculina turpethum Linn. BMC Complementary and Alternative Medicine. 2014; 14:479. doi: 10.1186/1472-6882-14-479
27. Kumar SVS, Sujatha C, Shymala J, Nagasudha B, Mishra SH. Protective effect of Root Extract of Operculina turpethum Linn. Against Paracetamol induced hepatotoxicity in Rats. Indian Journal of Pharmaceutical Sciences. 2006; 68(1):32-35.
28. Ahmad R. Ahmed S, Khan NU, Hasnain A. Operculina turpethum attenuates N-nitrosodimethylamine induced toxic liver injury and clastogenicity in rats. Chemico- Biological Interactions. 2009; 181(2):145-153.
29. Sharma V, Singh M. Attenuation of N-nitrosodimethylamine induced hepatotoxicity by Operculina turpethum in Swiss Albino mice. Iran Journal of Basic Medical Sciences. 2014; 17(1):73-80
30. Vijayabhaskar K, Mathukumalli SL, Prasad KC. Hepatoprotective Activity of Methanolic Extract On Operculina turpethum Rhizzoms Against Carbon tetrachloride Induced Toxicity. European Journal of Biomedical and Pharmaceutical sciences. 2017; 4(2):229-233.
31. Ahmad T, Mateen A, Waheed MA, Rasheed NMA, Ahmad SG, Alam MI et al. Antimicrobial activity of some herbal drugs used in Unani system of medicine. International Journal of Herbal Medicine. 2015; 2(5):27-30.
32. Ahmed A, Howlader MSI, Dey SK, Hira A, Hossain MH, Uddin MMN. Phytochemical screening and antibacterial activity of different fractions of Operculina turpethum root and leaf. American Journal of Scientific And Industrial Research. 2013; 4(2):167-172.
33. Anbuselvam C, Vijayavel K, Balasubramanian MP. Protective effect of Operculina turpethum against 7,12dimethylbenz (a) anthracene induced oxidative stress with reference to breast cancer in experimental rats. Chemico Biological Interactions. 2007; 168(3):229-236.
34. Umamaheswari S, Ghose S, Sangeetha KSS. Anticancer Potential of Operculina Turpethum in MCF-7 Human Breast Cancer Cell Lines. Journal of Chemical and Pharmaceutical Research. 2017; 9(9):44-48.
35. Islam MN, Nyeem MAB, Taher MA, Awal A. Analgesic and CNS Depressant Effect of the Crude Ethanolic Extract of the Operculina turpethum. Biosensors Journal. 2015; 4(2):132. doi:10.4172/2090-4967.1000132.
36. Onoja SO, Madubuike GK, Ezeja MI, Chukwu C. Investigation of the Laxative Activity of Operculina turpethum Extract in Mice. International Journal of Pharmaceutical and Clinical Research. 2015; 7(4):275-279.
37. Sudan P, Jain UK, Sharma S, Kaur R. A Critical Insight into Role of Herbal Drugs in Obesity. World Journal of Pharmacological Research and Technology. 2016; 4(2):59-69.
38. Sharma V, Singh M. In vitro antiarthritic and hemolysis preventive: Membrane stabilizing efficacy of ethanolic root extract of Operculina turpethum. World J Pharm Pharm Sci. 2013 d; 2:302-12.
2. Kohli KR, Nipanikar SU, Kadbhane KP. A Comprehensive Review on Trivrit [Operculina turpethum Syn. Ipomoea turpethum]. International Journal of Pharma and Bio Sciences. 2010; 1(4):443-452.
3. Anonymous. Standardization of single Drugs of Unani Medicine, Part1.CCRUM, Ministry of Health and Family Welfare, Department of AYUSH. New Delhi, 2006.
4. Kirtikar KR, Basu BD. Indian Medicinal Plants. International Book Distributors. Dehradun, 2005, III.
5. Hooker SJD, Kosi CB. Flora of British India, 1982, III.
6. Nadkarni KM. Indian Materia Medica. Popular Prakashan. Bombay, 2009, 3(I).
7. Gupta S, Ved A. Operculina turpethum (Linn.) Silva Manso as a Medicinal Plant Species: A Review on Bioactive Components and Pharmacological Properties. Pharmacogn Rev. 2017; 11(22):158-66.
8. Ghani N. Khazainul Advia. Idara Kitabul Shifa. New Delhi. YNM.
9. Anonymous. The Unani Pharmacopoeia of India, Part I. 1, 5. Ministry of Health and Family Welfare, Department Of AYUSH. New Delhi, 2007.
10. Rafeequddin M, Kanzul advia mufradat. Aligarh Muslim University Press, 1985.
11. Dymock W, Hooper D, Warden CJH, Pharma cographica Indica (A history of the principal drugs of vegetables origin). Thacker, Spink& Co. Calcutta, 1890, III.
12. Said HM. Al Biruni’s book on pharmacy and material medica, Hamdard National Foundations. Karachi, 1973
13. Sina I Alqanoon fit tibb (Urdu Translation by Hakeem Ghulam Husain Kantoori). Idara e Kitab us shifa. New Delhi, 2007, II.
14. Ahmad T, Husain MK, Tariq M, Siddiqui JI, Khalid M, Ahmed MW, Kazmi MHA. Review on Operculina turpethum: A Potent Herb of Unani System of Medicine. Journal of Pharmacognosy and Phytochemistry. 2017; 6(1):23-26.
15. Safiuddin HS. Unaniadvia mufrada. Ed1st.Qaumi council baraefaroghurdu zaban. New Delhi, 1979
16. Hakeem MA. Bustanul Mufradat. Idara KitabusShifa. New Delhi, 2002.
17. Hazique MM. Tuzeehuladvia. Matba Gulzar Mohammad. Meerut, 1894.
18. Sharma V, Singh M. Operculina turpethum as a panoramic herbal medicine: a review. International Journal of Pharmaceutical Sciences and Research. 2012; 3(1):21-25.
19. Khare AK. A preliminary study of anti-inflammatory activity of Ipomoea turpethum (Nisoth). Indian Drugs. 1982.
20. Bhande RM. Pharmacological Screening of Root of Operculina turpethum and its Formulations. Acta Pharmaceutica Sciencia. 2006; 48:11-7.
21. Prabhavati NB, Kowsalya B, Kumar SR, Sravani BJ, Sri GD, Sakila A et al. Analgesic activity of different solvent extract of Operculina turpethum by using swiss albino mice. Asian Journal of Pharmaceutical and Clinical Research. 2012; 5(3):215-218.
22. Ignatius V, Narayanan, M, Subramanian V, Periyasamy BM. Antiulcer activity of indigenous plant Operculina turpethum L. Evidence Based Complimentary and Alternative Medicine, 2013, 1-7. http: //dx. doi. org/ 10.1155/ 2013 / 272134.
23. Mahurkar N, Malpani AA, Inamdar SS, Hasan SMS, Madri SG. Chronopharmacological Influence of Operculina turpethum in Pylorus Ligated Albino rats. RGUHS Journal of Pharmaceutical Sciences. 2012; 2(4):74-79.
24. Pulipaka S, Challa SR, Pingili RB. Comparative antidiabetic activity of methanolic extract of Operculina turpethum stem and root against healthy and streptozotocin induced diabetic rats. International Current Pharmaceutical Journal. 2012; 1(9):272-278
25. Raut NA, Kasliwal AR, Gaikwad NJ. Evaluation of Antidiabetic Potential of Ipomoea turpethum R.Br. and Ipomoea batata L. (Convolvulaceae) in Alloxan Induced Diabetes in Rats: A Comparative Study. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014; 5(6):137-41.
26. Shareef H, Rizwani GH, Mandukhail SR, Watanabe N, Gilani AH. Studies on antidiarrhoeal, antispasmodic and bronchodilator activities of Operculina turpethum Linn. BMC Complementary and Alternative Medicine. 2014; 14:479. doi: 10.1186/1472-6882-14-479
27. Kumar SVS, Sujatha C, Shymala J, Nagasudha B, Mishra SH. Protective effect of Root Extract of Operculina turpethum Linn. Against Paracetamol induced hepatotoxicity in Rats. Indian Journal of Pharmaceutical Sciences. 2006; 68(1):32-35.
28. Ahmad R. Ahmed S, Khan NU, Hasnain A. Operculina turpethum attenuates N-nitrosodimethylamine induced toxic liver injury and clastogenicity in rats. Chemico- Biological Interactions. 2009; 181(2):145-153.
29. Sharma V, Singh M. Attenuation of N-nitrosodimethylamine induced hepatotoxicity by Operculina turpethum in Swiss Albino mice. Iran Journal of Basic Medical Sciences. 2014; 17(1):73-80
30. Vijayabhaskar K, Mathukumalli SL, Prasad KC. Hepatoprotective Activity of Methanolic Extract On Operculina turpethum Rhizzoms Against Carbon tetrachloride Induced Toxicity. European Journal of Biomedical and Pharmaceutical sciences. 2017; 4(2):229-233.
31. Ahmad T, Mateen A, Waheed MA, Rasheed NMA, Ahmad SG, Alam MI et al. Antimicrobial activity of some herbal drugs used in Unani system of medicine. International Journal of Herbal Medicine. 2015; 2(5):27-30.
32. Ahmed A, Howlader MSI, Dey SK, Hira A, Hossain MH, Uddin MMN. Phytochemical screening and antibacterial activity of different fractions of Operculina turpethum root and leaf. American Journal of Scientific And Industrial Research. 2013; 4(2):167-172.
33. Anbuselvam C, Vijayavel K, Balasubramanian MP. Protective effect of Operculina turpethum against 7,12dimethylbenz (a) anthracene induced oxidative stress with reference to breast cancer in experimental rats. Chemico Biological Interactions. 2007; 168(3):229-236.
34. Umamaheswari S, Ghose S, Sangeetha KSS. Anticancer Potential of Operculina Turpethum in MCF-7 Human Breast Cancer Cell Lines. Journal of Chemical and Pharmaceutical Research. 2017; 9(9):44-48.
35. Islam MN, Nyeem MAB, Taher MA, Awal A. Analgesic and CNS Depressant Effect of the Crude Ethanolic Extract of the Operculina turpethum. Biosensors Journal. 2015; 4(2):132. doi:10.4172/2090-4967.1000132.
36. Onoja SO, Madubuike GK, Ezeja MI, Chukwu C. Investigation of the Laxative Activity of Operculina turpethum Extract in Mice. International Journal of Pharmaceutical and Clinical Research. 2015; 7(4):275-279.
37. Sudan P, Jain UK, Sharma S, Kaur R. A Critical Insight into Role of Herbal Drugs in Obesity. World Journal of Pharmacological Research and Technology. 2016; 4(2):59-69.
38. Sharma V, Singh M. In vitro antiarthritic and hemolysis preventive: Membrane stabilizing efficacy of ethanolic root extract of Operculina turpethum. World J Pharm Pharm Sci. 2013 d; 2:302-12.
Published
12-02-2023
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Bashir F. Prophylactic aspects and therapeutic potential of Turbud (Operculina turpethum L) in Unani medicine: An evidence-based appraisal. J. Drug Delivery Ther. [Internet]. 2023 Feb. 12 [cited 2025 May 23];13(2):121-5. Available from: https://www.jddtonline.info/index.php/jddt/article/view/5947
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How to Cite
1.
Bashir F. Prophylactic aspects and therapeutic potential of Turbud (Operculina turpethum L) in Unani medicine: An evidence-based appraisal. J. Drug Delivery Ther. [Internet]. 2023 Feb. 12 [cited 2025 May 23];13(2):121-5. Available from: https://www.jddtonline.info/index.php/jddt/article/view/5947
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