Structural Establishment and Biological Evaluation of Newly Synthesized Nitrogen Containing Hetrocyclic Compound of Pyridazinone and its Derivatives
Abstract
Some new 6-phenyl–pyridazine-3-one were synthesized by hydrazinolysis of appropriate β-(substituted aryl) propionic acid and were converted into corresponding bis-pyridazinone (M-1 to M-6). All these synthesized compounds were characterized on the basis of spectral data and evaluated for their anticonvulsant activity.
Keywords: Pyridazine-3-One, anticonvulsant activity, synthesis
Keywords:
Pyridazine-3-One, anticonvulsant activity, synthesisDOI
https://doi.org/10.22270/jddt.v13i8.5940References
1. Pieretti S, Pia V.D, Matucci.R, Giovannoni.M. Synthesis of 3-(2H)- Pyridazinone derivative and their antinociceptive activity. J. Of life sciences. 1999; 65:1381-1394, https://doi.org/10.1016/S0024-3205(99)00377-X
2. Xup, Wang S.Y, Liu W.Q. Synthesis and anticancer activity of 6-(substituted phenyl) - 3 (2H) pyridazinones. J.Of Agric food Chem. 2002; 50:357-3760.
3. Rubat C, Coudert P, Refouvelet B, Tronche P, Bastide P. Synthesis and anticonvulsant activity of 3-oxo-5-substituted Benzylidene-6-methyl-(4H)-2-Pyridazinylacetamides and 2-Pyridazinylacetylhydrazides. Chem. Pharm. Bull. 38(11), 3009-3013 (1990). Mikashima H, Nakao T, Kazuhiro G. Synthesis of new Pyridazinone derivatives and their antithrombotic activity. J. Of Thrombosis Research. 1984; 35:589-609. https://doi.org/10.1248/cpb.38.3009
4. Siddiqui A.A, Kushnoor A, Wani S.M. Synthesis and antiinflammatory activity of 6-(Substituted aryl)-2,3,4,5-tetrahydro-3-thiopyridazinones. Indian J. Of Hetrocyclic Chem. 2004; 13:257-260. https://doi.org/10.1002/chin.200445172
5. Khan M.S.Y, Siddiqui A.A. Synthesis and antiinflammatory activity of some 6-aryl-2,3,4,5-tetrahydro-3-Pyridazinones. Indian J.Of Hetrocyclic Chem. 2000; 39B:614-619. https://doi.org/10.1002/chin.200104167
6. Mogilaiah K, Kankaiah G. Synthesis of 6-aryl-2-(2-phenyl-1,8-naphthyridine-3-carbonyl)-4,5-dihydro-pyridazin-3(2H)-ones. Indian J. Chem. 2003; 42B:658-660. https://doi.org/10.1002/chin.200324120
7. Sumakanth M, Malla R.V, Krishnan V.S.H, Sastry B.S. Synthesis and pharmacological evaluation of new 2,6-disubstituted-2H-Pyridazin-3-ones. J.Of Pharmaceutical Research. 2007; 6:166-169.
8. Siddiqui A.A, Khusnoor A, Ahmad S.R. synthesis and pharmacological activity of 4-substituted benzoyl methyl Pyrazolidin-3-ones. Indian drug. 2005; 2:127-132.
9. Siddiqui A.A, Khusnoor A, Ahmad S.R. synthesis and pharmacological activity of 4-substituted benzoyl methyl Pyrazolidin-3-ones. Indian drug. 2005; 2:127-132.
Published
Abstract Display: 25
PDF Downloads: 57
PDF Downloads: 12 How to Cite
Issue
Section
Copyright (c) 2023 Shailendra Kumar Verma, Anshika Choudhary, Yashpal Singla

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

.