Formulation and Evaluation of Gas Powered Systems of Cefepime Tablets for Controlled Release
Abstract
With the use of several hydrophilic and hydrophobic polymers such HPMC, Ethyl cellulose, Xanthum gum, and guar gum as well as the gas-producing substance Sodium bicarbonate, the current work aims to create Cefepime floating tablets. The creation of a gastro-retentive dosage form allowed scientists to deliver the medication to the stomach, the site of action for Cefepime, for extended periods of time. Guar gum and Xanthum gum are utilized as binding agents, and HPMC is employed as a swelling agent. The substance utilized to create the matrix is ethyl cellulose. As a suspending agent, PVP is employed. A gas-forming agent is sodium bicarbonate. MCC is employed as a diluent and a disintegrant. A lubricant called magnesium stearate is employed. Drug content, entrapment effectiveness, post compression tests, in-vitro buoyancy studies, swelling index studies, in-vitro dissolving studies, release kinetics, and stability studies will all be assessed for the manufactured Cefepime tablets. The pharmacopoeial limits were determined to apply to each of these parameters. On the basis of relevant findings from the post compression investigation, Formulation F5 was chosen for the drug release and stability study. A regulated release pattern was revealed by an in vitro dissolution investigation.
Keywords: Gas Powered Systems, Cefepime, Controlled release, Floating drug delivery.
Keywords:
Gas Powered Systems, Cefepime, Controlled release, Floating drug deliveryDOI
https://doi.org/10.22270/jddt.v12i6-S.5883References
Kaushik A, Dwivedi A, Kothari P, Govil A. Floating drug delivery system a significant tool for stomach specific release of cardiovascular drugs. Int J Drug Dev Res. 2012; 4(4):116- 129.
Mathur P, Saroha K, Syan N, Verma S, Kumar V. Floating drug delivery system: An innovative acceptable approachin gastroretentive drug delivery. Arch Appl Sci Res. 2010; 2(2):257-270.
Desai S, Bolton SA. A floating controlled release drug delivery system: In vitro-In vivo evaluation. Pharm Res 1993; 10(9):1321-1325. https://doi.org/10.1023/A:1018921830385
Amrutkar PP, Chaudhari PD, Patil SB. Design and in vitro evaluation of multiparticulate floating drug delivery system of zolpidemtartarate. Colloid Surface B., 2012; 89:182-187. https://doi.org/10.1016/j.colsurfb.2011.09.011
Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford; ISBN 326 9780191039621, 2009, pp. 56.
Ponchel G, Irache J-M. Specific and non-specific bioadhesive participate systems for oral delivery to the gastrointestinal tract. Adv Drug Deliver Rev 1998; 34:191-219. https://doi.org/10.1016/S0169-409X(98)00040-4
Deshpande AA, Shah NH, Rhodes CT, Malick W. Development of a novel controlled release system for gastric retention. Pharm Res. 1997; 14:815-819. https://doi.org/10.1023/A:1012171010492
Davis SS, Stockwell AF, Taylor MJ et al. The effect of density on the gastric emptying of single- and multiple-unit dosage forms. Pharm Res. 1997; 3: 208-213. https://doi.org/10.1023/A:1016334629169
Klausner EA, Lavy E, Friedman M, Hoffman A. Expandable gastroretentive dosage forms. J Control Release 2003; 90:143- 162. https://doi.org/10.1016/S0168-3659(03)00203-7
Kedzierewicz F, Thouvenot P, Lemut J, Etienne A, Hoffman M, Maincent P. Evaluation of peroral silicone dosage forms in humans by gamma-scintigraphy. J Control Release. 1999; 58:195-205. https://doi.org/10.1016/S0168-3659(98)00154-0
Groning R, Heun G. Oral dosage forms with controlled gastrointestinal transit. Drug Dev Ind Pharm. 1984; 10:527- 539. https://doi.org/10.3109/03639048409041405
Chawla G, Gupta P, Koradia V, Bansal AK. Gastroretention a means to address intestinal drug absorption. Pharm Technol 2003; 27:50-68.
Singh BN and Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control. Release. 2000; 63:235-239. https://doi.org/10.1016/S0168-3659(99)00204-7
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