Formulation and evaluation of Lamivudine transferosomal gel
Abstract
Aim and objective: The aim of the study was to formulate and evaluate Transferosomal gel of lamivudine.
Method:Lamivudine transferosomes was prepared using thin film hydration method taking span 80, Polyoxyethylene lauryl ether in different proportion. the formulation was characterised by UV spectroscopy, FTIR, in-vitro drug release, gel evaluations.
Results: Total nine formulations were formulated and optimised formulation F3 showed entrapment efficiency EE (91.17), %CDR (96.12) and small particle size (98.19 nm). SEM of optimized lamivudine Transferosomes appeared as spherical, well identified, unilamellar vesicles. The optimized formulation of Transferosomes was further formulated to gel with Poloxamer 407 gel 0.5%, 1% and 2% w/w ,HPMC k15, Propylene glycol, DMSO. Among these F3 formulation with Poloxamer 407 2%w/w transferosomal gel is the optimised transferosmal gel and showed Spreadability value 6.01±0.12 cm, pH value 5.01 ±0.47. The actual drug content of the Transferosomal gel was found to be 97.29 ±0.66%, which represents good content uniformity. The viscosity of lamivudine Transferosomal gel is found to 5960 ±0.75cps. The percentage drug release for lamivudine Transferosomal gel is 97.31 %. stability studies showed that Transferosomal gel is more stable at 4˚C when compared to other temperatures. The future scope of the study is to perform the In Vivo studies to evaluate the potency of the prepared formulation.
Keywords: Lamivudine Transferosomal gel, Transferosomes, Topical, Anti-viral drug, Thin Film Hydration Technique.
Keywords:
Lamivudine Transferosomal gel, Transferosomes, Topical, Anti-viral drug, Thin Film Hydration TechniqueDOI
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