Case Report on Phenytoin-Induced Toxic Epidermal Necrolysis

Authors

  • Nishoja David Pharm. D Intern Department of Pharmacy Practice KLE College of Pharmacy, Vidyanagar Hubballi. A Constitute Unit of K.L.E Academy of Higher Education and Research, Belagavi, Karnataka, INDIA
  • Prasad N Bali Assistant Professor Pharm.D, Department of Pharmacy Practice KLE College of Pharmacy, Vidyanagar Hubballi. A Constitute Unit of K.L.E Academy of Higher Education and Research, Belagavi, Karnataka, INDIA
  • AHM Vishwanath Swamy Principal & Professor Department of Pharmacy Practice KLE College of Pharmacy , Vidyanagar, Hubballi

Abstract

Toxic epidermal necrolysis is a cutaneous drug reaction which is a severe adverse effect that predominantly involves the skin and mucous membrane. Phenytoin is an anti-epileptic medication that belongs to the hydantoin class. Here we are going to present a case of 50-year-old male patient with phenytoin induced toxic epidermal necrolysis. The outcome of this study was to determine the severity of the adverse reaction and its management to improve the patient condition.  

Keywords: Toxic epidermal necrolysis, phenytoin, erythromatous, adverse drug reaction, body surface area.

Keywords:

oxic epidermal necrolysis, phenytoin, erythromatous, adverse drug reaction, body surface area

DOI

https://doi.org/10.22270/jddt.v12i4-S.5595

Author Biographies

Nishoja David, Pharm. D Intern Department of Pharmacy Practice KLE College of Pharmacy, Vidyanagar Hubballi. A Constitute Unit of K.L.E Academy of Higher Education and Research, Belagavi, Karnataka, INDIA

Pharm. D Intern Department of Pharmacy Practice KLE College of Pharmacy, Vidyanagar Hubballi. A Constitute Unit of K.L.E Academy of Higher Education and Research, Belagavi, Karnataka, INDIA

Prasad N Bali, Assistant Professor Pharm.D, Department of Pharmacy Practice KLE College of Pharmacy, Vidyanagar Hubballi. A Constitute Unit of K.L.E Academy of Higher Education and Research, Belagavi, Karnataka, INDIA

Assistant Professor Pharm.D, Department of Pharmacy Practice KLE College of Pharmacy, Vidyanagar Hubballi. A Constitute Unit of K.L.E Academy of Higher Education and Research, Belagavi, Karnataka, INDIA

AHM Vishwanath Swamy, Principal & Professor Department of Pharmacy Practice KLE College of Pharmacy , Vidyanagar, Hubballi

Principal, KLE College of Pharmacy, Vidyanagar   Hubballi. A Constitute Unit of K.L.E Academy of Higher Education and Research, Belagavi, Karnataka, INDIA

References

Mudigubba MK, Mahantheswarapa Y, Moola K, Bathula G, Rajashekarachar Y, Raghunathnaidu BD. Toxic epidermal necrolysis induced by Phenytoin: A case study. Indian Journal of Pharmacy Practice. 2014; 7(2):37–9.

Tripathi K. Essentials of Medical Pharmacology. Jaypee Brothers, Medical Publishers Pvt. Limited; 2008

Zaki SA. Adverse drug reaction and causality assessment scales [Internet]. Lung India: official organ of Indian Chest Society. Medknow Publications; 2011 [cited 2022Jul6]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109846/

Christa Prins MD. Treatment of toxic epidermal necrolysis with high-dose intravenous immunoglobulins [Internet]. Archives of Dermatology. JAMA Network; 2003 [cited 2022Jul6]. Available from: https://jamanetwork.com/journals/jamadermatology/fullarticle/479146#:~:text=Conclusions%20Early%20infusion%20of%20high,per%20day%20for%203%20days).

Published

2022-08-15
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How to Cite

1.
David N, Bali PN, Swamy AV. Case Report on Phenytoin-Induced Toxic Epidermal Necrolysis. J. Drug Delivery Ther. [Internet]. 2022 Aug. 15 [cited 2025 Nov. 14];12(4-S):1-2. Available from: https://www.jddtonline.info/index.php/jddt/article/view/5595

How to Cite

1.
David N, Bali PN, Swamy AV. Case Report on Phenytoin-Induced Toxic Epidermal Necrolysis. J. Drug Delivery Ther. [Internet]. 2022 Aug. 15 [cited 2025 Nov. 14];12(4-S):1-2. Available from: https://www.jddtonline.info/index.php/jddt/article/view/5595

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