LIQUISOLID TECHNIQUE: AN APPROACH FOR ENHANCEMENT OF SOLUBILITY

Abstract

Liquisolid technique is also known as powder solution technology. It is the technique which deals with the solubility enhancement of poorly soluble drugs. As these days there are many drugs in the market with poor solubility which leads to poor dissolution and bioavailability, so solubility is becoming rate limiting factor in the development of new drugs. To overcome this problem there are many techniques but liquisolid technique is most promising technique which is discussed in this article. Liquisolid is mainly composed of drug, non volatile solvent, carrier material, coating material, and disintegrant. In liquisolid technique carrier and coating material which should be in the ratio of 20:1 is mixed into the non volatile solvent and then disintegrant is added and final material is compressed into tablets. Hence, the liquisolid technology allows the transformation of liquid systems into solid drug delivery systems. Both immediate and sustained release of drug can also be achieved with the help of liquisolid technique. For sustained release of drug hydrophilic polymer like Hydroxy Propyl Methyl Cellulose can be the best option. The purpose of this article is to describe about the liquisolid technique like basics, classification, preformulation studies, characterisation, precompression studies, formulation of tablet, postcompression studies, advantages, disadvantages, applications.