A Comprehensive Review on Sustained Release Matrix Drug Delivery System
Abstract
Formulations for sustained medication release are very useful in the treatment of chronic disorders. The oral route has selected matrix tablets as the most likely type of prolonged drug release. In order to generate therapeutic activity for a protracted duration, matrix tablets maintain a stable plasma drug concentration and sustain the rate of release of the drug throughout time. In preparations with a short half-life and high dosage frequency, extended-release is crucial. The matrix regulates how quickly the medication is released. Retardants such polyglycolic acid, polymethyl methacrylate, and hydroxypropyl methylcellulose (HPMC) are used. The retardant's matrix core contains the medication. The matrices employed can be mineral-based, hydrophobic, or biodegradable. Drug release is regulated in matrix tablets that can be made using wet granulation or direct compression techniques by the use of various kinds of polymers. Drug release from matrix tablets is controlled by both diffusion- and dissolution-controlled process. As a result, matrix tablets increase therapeutic efficacy while reducing the frequency of drug administration and increasing patient compliance.
Keywords: Sustained release, Matrix Tablets, HPMC, Retardants, Biodegradable
Keywords:
Sustained release, Matrix Tablets, HPMC, Retardants, BiodegradableDOI
https://doi.org/10.22270/jddt.v12i4-S.5540References
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