Review on Atherogenic Index of Plasma Lipids and Dyslipidemia

Authors

Abstract

Dyslipidemia is defined as abnormally levels of lipids in the blood. Different types of lipids and lipoproteins have been identified. Dyslipidemia is a single strong risk factor for the development of cardiovascular events and atherosclerosis is the most common. It has been described as a disease of the economically advanced societies, but recently, it has found its way into the semi-urban societies and among its dwellers, who are at the increasing risk of developing cardiovascular accidents. Hence, early identification and diagnosis of dyslipidemia at its earliest stage among this populace is a worthwhile cardiovascular preventive measure. The study of hyperlipidaemia is of considerable importance, mainly because of the involvement of lipids in cardiovascular diseases. The classification system of hyperlipidaemia is based on which plasma lipoprotein concentrations were increased. Fredrickson classification helped to put lipidology on the clinical map, though it was not a diagnostic classification. It gives little clue as to the aetiology of the disorder. Currently, a more descriptive classification is used for the primary hyperlipidaemia although they can be genetic or secondary factors. This review presents the overview of plasma lipids. This article illustrates the theoretical background and details about dyslipidemias.

Keywords: Dyslipidemia, Atherogenic index, Hyperlipidaemia, Atherosclerosis, Lipoproteins

Keywords:

Dyslipidemia, Atherogenic index, Hyperlipidaemia, Atherosclerosis, Lipoproteins

DOI

https://doi.org/10.22270/jddt.v12i4-S.5477

Author Biographies

Ifunanyachukwu Confidence Onuchukwu, Department of Medical Laboratory Science, Abia State University, Uturu, Abia State, Nigeria.

Department of Medical Laboratory Science, Abia State University, Uturu, Abia State, Nigeria.

Echu Ukam Etim, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria

Omejua Godswill Chimdike, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Blessing Chinyere Oguzie, Department of Medical Laboratory Science, Abia State University, Uturu, Abia State, Nigeria

Department of Medical Laboratory Science, Abia State University, Uturu, Abia State, Nigeria

Hilary Emuebie, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Kelvin Nkemakonam Orji, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Livia Chinaza Egoh, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Ebubechukwu Lovelyn Ofojama, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Gift Ifechukwu Okonkwo, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Amokeoja Olayinka Timothy, Department of Health Information Management, Obafemi Awolowo University Teaching Hospital, Ife, Osun State, Nigeria.

Department of Health Information Management, Obafemi Awolowo University Teaching Hospital, Ife, Osun State, Nigeria.

Comfort Chinwendu Igwe, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Favour Chizaram Sunday, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Chisimdindu Frances Nnaji, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Chiagoziem Henry Ekemezie, Department of Medical Laboratory Science, Nnamdi Azikikwe University, Awka, Anambra State, Nigeria.

Department of Medical Laboratory Science, Nnamdi Azikikwe University, Awka, Anambra State, Nigeria.

Unoaku Judith Ikwueze, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Chibuike Emmanuel Maduekwe, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Sheriffdeen Adedolapo Adebisi, Department of Pharmacy, Olabisi Onabanjo University. Ogun State, Nigeria.

Department of Pharmacy, Olabisi Onabanjo University. Ogun State, Nigeria.

Vivian Onyinyechi Nnanyereugo, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria

Kelechi Victor Ihedi, Department of Medical Laboratory Science, River State University, Port-Hartcourt, Rivers State, Nigeria.

Department of Medical Laboratory Science, River State University, Port-Hartcourt, Rivers State, Nigeria.

Onyinyechukwu Vivian Ifionu, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Sharon Obianuju Eze, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Chisom Nwabundo Okafor, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Victor Chisom Makata, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Samuel Edwin Inalegwu, Department of Medical Laboratory Science, University of Jos, Plateau State, Nigeria.

Department of Medical Laboratory Science, University of Jos, Plateau State, Nigeria.

Juliet Uzorchi Joboson, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Carmilla Ijeoma Udensi, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Olatunji Omokungbe, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Prince Ikechukwu Onuoha, Department of Medical Laboratory Science, University of Lagos, Lagos State, Nigeria.

Department of Medical Laboratory Science, University of Lagos, Lagos State, Nigeria.

Chikwube Collins Ajibo, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Moses Ejiofor Agbo, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Goodluck Oghenerukevwe Okoro, Department of Medical Laboratory Science, University of Lagos, Lagos State, Nigeria.

Department of Medical Laboratory Science, University of Lagos, Lagos State, Nigeria.

Amarachi Cynthia Uba, Department of Biomedical Technology, University of Port Hacourt, Rivers State, Nigeria.

Department of Biomedical Technology, University of Port Hacourt, Rivers State, Nigeria.

Chioma Mascillina Offor, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Ikenna Kingsley Uchendu, Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

Department of Medical Laboratory Science, University of Nigeria Enugu Campus, Enugu State, Nigeria.

References

Uchendu IK, Ekeigwe IB, Nnedu EB. Antidyslipidaemic and cardioprotective effects of turmeric (Curcuma longa) in rat fed a high cholesterol diet. Journal of Drug Delivery and Therapeutics, 2020; 15; 10(1-s):178-81. https://doi.org/10.22270/jddt.v10i1-s.3869

Eriksson JG, Forsen T, Tuomilehto J, Osmond C, Barker DJ. Early growth and coronary heart disease in later life: longitudinal study. British medical journal 2001, 21; 322(7292):949-53. https://doi.org/10.1136/bmj.322.7292.949

Uchendu IK, Onwukwe SO, Agu CE, Orji CO, Eluke BC, Nwosu TF. Hypolipidaemic and renoprotective effects of Glycine max (soy bean) against lipid profile and renal biochemical alterations in hypercholesterolemic rat. International Journal of Biomedical Research. 2016; 7:822-828.

Collabero B. Obesity in developing countries- Biological and ecological factors. Symposium Journal of nutrition supplement 2001; 131:866-870.

Silver I, Nyerhovwo, JT. The influence of dietary intake on the serum lipid profile, body mass and risk of cardiovascular disease in adults on the Niger Delta region. Journal of nutrition and metabolism 2010; 2(3):40-44.

Martin AC. Plasma lipids and lipoproteins: In Clinical biochemistry and metabolic medicine, 8th Edition.2012, 210-225.

Bach DW. (2010). Phospholipids/ cholesterol model membrans. Formation of cholesterol crystallates. Biochemica et biophysica Acta, 2010, 1610(2): 187-197. https://doi.org/10.1016/S0005-2736(03)00017-8

Nader R, Warnick, RG, Remaley TA. Lipids, lipoprotein, apolipoprotein and other cardiac risk factors: In Tietz fundamental of clinical chemistry and molecular diagnostics. Burtis, C. A. and Bruns (Editors), 5th Edition. 2015, 388-411.

Dinasarapu AR, Saunders B, Ozerlat I. Azam K, Subramaniam S. Signalling gateway molecules pages - a data model perspective. Bioinformatives 2011; 27(12):1736-1738. https://doi.org/10.1093/bioinformatics/btr190

Klein C, Malviya, AN. Mechanism of nuclear calcium signalling by inositol 1, 4, 5-triphosphate produced in the nucleus, nuclear located protein kinase C and cyclic AMP dependent protein kinase. Frontiers in Bioscience 2008; 13(13):1206-1226. https://doi.org/10.2741/2756

Fezza F, De simone, C, Amadio D, Maccarone. Fatty acids amide hydrolase: a gatekeeper of the endocannabinoid system. Subcellular biochemistry 2008; 49:101-132. https://doi.org/10.1007/978-1-4020-8831-5_4

Honke K, Zhang Y, Cheng X, Kotani N, Taniguchi N. Biological roles of sulfoglycolipids and pathophysiology of their deficiency. Glycoconjugate Journal 2009; 21(1-2):59-62. https://doi.org/10.1023/B:GLYC.0000043749.06556.3d

Segre D, Ben-Eli D, Deamer DW, Lancet D. The lipid world. Origins of life and evolution of the biosphere 2001; 31(1-2):119-145. https://doi.org/10.1023/A:1006746807104

Walsh CT. Polyketide and non-ribosomal peptide antibiotics. Modularity and versatility science 2009; 303(5665):1805-1810. https://doi.org/10.1126/science.1094318

Yashroy RC. 13C NMR studies of lipid fatty acyl chains of chloroplast membrane. Indian Journal of Biochemistry 2007; 24(6):177-178.

Eyster KM. The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemistry. Advances in physiology Education 2007; 31(1):5-16. https://doi.org/10.1152/advan.00088.2006

Hunter JE. Dietary trans fatty acids: review of recent human studies and food industry responses. Lipids 2010; 41(11):967-992. https://doi.org/10.1007/s11745-006-5049-y

Parks EJ. Dietary carbohydrates effects on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentration. British Journal of Nutrition 2002; 87:5247-5453. https://doi.org/10.1079/BJN/2002544

Sembulingam K, Sembulingam P. Digestion, absorption and metabolism of lipids: In Essentials of medical physiology. JP Medical Ltd; 2012, 292-301. https://doi.org/10.5005/jp/books/11696_125

Karam I, Yang YJ, Li JY. Hyperlipidemia background and progress. SM Atherosclerosis Journal 2017; 1(1):1003.

Raman M, Almutairdi A, Mulesa L, Alberda C, Beattie C, Gramlich L. Parenteral nutrition and lipids. Nutrients. 2017; 9(4):388. https://doi.org/10.3390/nu9040388

Tomkin GH, Owens D. LDL as a cause of atherosclerosis. The Open Atherosclerosis and Thrombosis Journal, 2012; 5:13-21. https://doi.org/10.2174/1876506801205010013

Arun B, Budha R, Jones E. Relationship between anthropometric measurements, atherogenic index of plasma and lipid profile among the healthy adults from an urban area. National Journal of Basic Medical Sciences 2015; 5 (3):74-77.

Aziz M, Yadav KS. Pathogenesis of atherosclerosis: A review. Medical and Clinical Review 2016; 2(3):1-6. https://doi.org/10.21767/2471-299X.1000031

Kuo TP. Dyslipidaemia and coronary artery disease. Clinical cardiology 1994; 17:519-527. https://doi.org/10.1002/clc.4960171003

Lily L. Pathophysiology of Heart Disease; A collaborative project of medical students and faculty. 3rd Edition. Lippincott Williams and Willns, Philadelphia. 2003, 133-144.

Van Epps J, Vorp D. Mechano-pathobiology of atherosclerosis. Journal of Surgical Research 2006, 142:202-217. https://doi.org/10.1016/j.jss.2006.11.001

Glass C, Witztum J. Atherosclerosis: The road ahead. Cell 2001; 104: 503-516. https://doi.org/10.1016/S0092-8674(01)00238-0

Gonzalez MA, Selwyn AP. Endothelial function, inflammation and prognosis in cardiovascular disease. American Journal of Medicine 2003; 115:99-106. https://doi.org/10.1016/j.amjmed.2003.09.016

National Cholesterol Education Programme. Detection, evaluation and treatment of high blood cholesterol in adults (adult panel III). Journal of American Medical Association 2002; 285:2486- 2497. https://doi.org/10.1001/jama.285.19.2486

Cullen P, Rauterberg J, Lorkowski S. The pathogenesis of atherosclerosis. Handbook of Experimental Pharmacology 2005; 170:3-70. https://doi.org/10.1007/3-540-27661-0_1

Lorkowski S, Cullen P. Atherosclerosis: pathogenesis, clinical feature and treatment. Encyclopedia of life sciences 2007; 1-11. https://doi.org/10.1002/9780470015902.a0004228

Olamoyegun MA, Oluyombo R, Olabode AS. Evaluation of dyslipidaemia, lipid ratio and atherogenic index as cardiovascular risk factors among semi-urban dwellers in Nigeria. Annals of African Medicine 2016; 15 (4):194-199. https://doi.org/10.4103/1596-3519.194280

Published

2022-08-15
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Onuchukwu IC, Etim EU, Chimdike OG, Oguzie BC, Emuebie H, Orji KN, et al. Review on Atherogenic Index of Plasma Lipids and Dyslipidemia. J. Drug Delivery Ther. [Internet]. 2022 Aug. 15 [cited 2025 Nov. 14];12(4-S):214-22. Available from: https://www.jddtonline.info/index.php/jddt/article/view/5477

Issue

Vol. 12 No. 4-S (2022): Volume 12, Issue 4-S, July-August 2022

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Review

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How to Cite

1.
Onuchukwu IC, Etim EU, Chimdike OG, Oguzie BC, Emuebie H, Orji KN, et al. Review on Atherogenic Index of Plasma Lipids and Dyslipidemia. J. Drug Delivery Ther. [Internet]. 2022 Aug. 15 [cited 2025 Nov. 14];12(4-S):214-22. Available from: https://www.jddtonline.info/index.php/jddt/article/view/5477
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