Formulation and Evaluation of Doxofylline-Loaded Polymeric Micelles for Pulmonary Administration
Abstract
The pulmonary administration of drugs offers advantages over administration by intravenous injection. The present research work was to prepare polymeric micelles nanomicelles containing Doxofylline as dry powder for inhalation. In order to bypass the drawbacks of predictable preparations, nanotechnology-based drug delivery systems for pulmonary administration and pulmonary targeting have been oppressed. The work was aimed towards formulating the Doxofylline loaded Soluplus nanomicelles with polymer Soluplus by film hydration technique in different ratios. The nanomicelles so prepared were characterized for its particle size, ζ-potential, XRD, SEM, drug content and drug release rate. Soluplus Doxofylline Polymeric Micelles showed mean size of 70.73nm and Zeta Potential is - 8.71. The Drug Entrapment Efficiency is 87.7% and The Drug Loading Capacity is 10%. In-Vitro study reveals the drug release is 44%. Conclusion: The Doxofylline-Soluplus Polymeric Nanomicelles could have the significant value in the treatment of Asthama and COPD.
Keywords: Polymeric Nanomicelles, Asthama, COPD, Doxofylline, Film Hydration Technique, Lyophilisation, Dry powder for Inhalation.
Keywords:
Polymeric Nanomicelles, Asthama, COPD, Doxofylline, Film Hydration Technique, Lyophilisation, Dry powder for InhalationDOI
https://doi.org/10.22270/jddt.v12i3.5472References
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