Description of Covid-19 Patients with Comorbidity
Abstract
Coronavirus Disease-19 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2). At this point, COVID-19 remains the main health issue worldwide, including in Indonesia, with existing risk factors. Comorbidities, smoking, male sex, and the elderly are some of its biggest risk factors. Current data about COVID-19 patients with comorbidities in Indonesia were limited, so this study was made to present more data about the clinical profile of COVID-19 with comorbidities. The descriptive retrospective method was used in this study with secondary data obtained from Christian University of Indonesia General Hospital medical records from January 2020 to December 2020 and aimed to describe the clinical profile of COVID-19 patients with comorbidities. Among 156 samples of COVID-19 patients that were found in this study according to inclusion and exclusion criteria, 91 patients (58,3%) had at least one comorbidity. They were distributed based on sex, age group, clinical symptoms, type of comorbidity, and the number of comorbidities in each patient. Based on sex distribution, there were 46 male patients (50,5%) and 45 female patients (49,5%). The most prevalent age group was 50 – 54 years old, with 14 patients (15,4%). Fever with 88 patients (95,9%), cough with 86 patients (93,8%), and dyspnea with 55 patients (60,8%) were the most common clinical symptoms. The most common types of comorbidity were hypertension with 66 patients (72,5%), diabetes mellitus (DM) with 20 patients (22,0%), and obesity with 14 patients (15,4%). There were 58 patients (63,8%) with only one comorbidity and 33 patients (36,3%) with ≥ 2 comorbidities. Prompt identification of comorbidities, public enlightenment about comorbidities with other risk factors of COVID-19, and complying with health protocols are recommended to decrease the proportion of COVID-19 patients with comorbidities.
Keywords: COVID-19, SARS-CoV-2, Comorbidity.
Keywords:
COVID-19, SARS-CoV-2, ComorbidityDOI
https://doi.org/10.22270/jddt.v12i4.5463References
V'kovski, Philip, Annika Kratzel, Silvio Steiner, Hanspeter Stalder, and Volker Thiel. "Coronavirus biology and replication: implications for SARS-CoV-2." Nature Reviews Microbiology 2021; 19(3):155-170. https://doi.org/10.1038/s41579-020-00468-6
Rozaliyani, Anna, Ary Indriana Savitri, Findra Setianingrum, Titania Nur Shelly, Vini Ratnasari, Romala Kuswindarti, Ngabila Salama, Dwi Oktavia, Widyastuti Widyastuti, and Diah Handayani. "Factors associated with death in COVID-19 patients in Jakarta, Indonesia: an epidemiological study." Acta Med Indones 2020; 52(3):46-254.
Del Sole, Francesco, Alessio Farcomeni, Lorenzo Loffredo, Roberto Carnevale, Danilo Menichelli, Tommasa Vicario, Pasquale Pignatelli, and Daniele Pastori. "Features of severe COVID‐19: a systematic review and meta‐analysis." European journal of clinical investigation 2020; 50(10):13378.
Karyono, Dionita Rani, and Anggi Lukman Wicaksana. "Current prevalence, characteristics, and comorbidities of patients with COVID-19 in Indonesia." Journal of Community Empowerment for Health 2020; 3(2):77. https://doi.org/10.22146/jcoemph.57325
Joseph, Tinku, M. Moslehi, K. Hogarth, A. Majid, and C. Meng. "International pulmonologist's consensus on COVID-19." International Pulmonologists Consensus on COVID 2020: 1-43.
Azwar, Muhammad Khifzhon, Siti Setiati, Aulia Rizka, Ika Fitriana, Siti Rizny F. Saldi, and Eka Dian Safitri. "Clinical profile of elderly patients with COVID-19 hospitalised in Indonesia's National General Hospital." Acta Medica Indonesiana 2020; 52(3):199.
Zhou, Fei, Ting Yu, Ronghui Du, Guohui Fan, Ying Liu, Zhibo Liu, Jie Xiang et al. "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study." The lancet 2020; 395(10229):1054-1062. https://doi.org/10.1016/S0140-6736(20)30566-3
Wu, Zunyou, and Jennifer M. McGoogan. "Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention." jama 2020; 323(13):1239-1242. https://doi.org/10.1001/jama.2020.2648
Diaz, J. V., John Appiah, Lisa Askie, April Baller, Anshu Banerjee, Shannon Barkley, Silvia Bertagnolio, Bianca Hemmingsen, Mercedes Bonet, and J. Cunningham. "COVID-19 clinical management: living guidance." World Heal Organ. Available at: https://www. who. int/publications/i/item/WHO-2019-nCoV-clinical-2021-1. Accessed 30 (2021).
Parasher, Anant. "COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment." Postgraduate medical journal 2021; 97(1147):312-320. https://doi.org/10.1136/postgradmedj-2020-138577
Azevedo, Thomás Cavalcanti Pires de, Pedro Vianna de Freitas, Pedro Henrique Padilha da Cunha, Eraldo Abillio Pereira Moreira, Thiago José Matos Rocha, Fabiano Timbó Barbosa, Célio Fernando de Sousa-Rodrigues, and Fernando Wagner da Silva Ramos. "Efficacy and landscape of Covid-19 vaccines: a review article." Revista da Associação Médica Brasileira 2021; 67:474-478. https://doi.org/10.1590/1806-9282.20210073
Ejaz, Hasan, Abdullah Alsrhani, Aizza Zafar, Humera Javed, Kashaf Junaid, Abualgasim E. Abdalla, Khalid OA Abosalif, Zeeshan Ahmed, and Sonia Younas. "COVID-19 and comorbidities: Deleterious impact on infected patients." Journal of infection and public health 2021; 13(12):1833-1839. https://doi.org/10.1016/j.jiph.2020.07.014
Sanyaolu, Adekunle, Chuku Okorie, Aleksandra Marinkovic, Risha Patidar, Kokab Younis, Priyank Desai, Zaheeda Hosein, Inderbir Padda, Jasmine Mangat, and Mohsin Altaf. "Comorbidity and its impact on patients with COVID-19." SN comprehensive clinical medicine 2020; 2(8):1069-1076. https://doi.org/10.1007/s42399-020-00363-4
World Health Organization (WHO). "Coronavirus. Geneva: WHO; 2020." Accessed 2020; 28:278.
Gorbalenya, Alexander E., Susan C. Baker, Ralph S. Baric, Raoul J. de Groot, Christian Drosten, Anastasia A. Gulyaeva, Bart L. Haagmans et al. "Severe acute respiratory syndrome-related coronavirus: The species and its viruses-a statement of the Coronavirus Study Group." BioRxiv (2020).
Denis, Martine, Valerie Vandeweerd, Rein Verbeeke, Anne Laudisoit, Tristan Reid, Emma Hobbs, Laure Wynants, and Diane Van der Vliet. "Covipendium: Information available to support the development of medical countermeasures and interventions against COVID-19." Transdisciplinary Insights 2020; 4(1):1-296. https://doi.org/10.11116/TDI2020.4.10.SI.Covipendium
Salian, Vrishali S., Jessica A. Wright, Peter T. Vedell, Sanjana Nair, Chenxu Li, Mahathi Kandimalla, Xiaojia Tang, Eva M. Carmona Porquera, Krishna R. Kalari, and Karunya K. Kandimalla. "COVID-19 transmission, current treatment, and future therapeutic strategies." Molecular pharmaceutics 2021; 18(3):754-771. https://doi.org/10.1021/acs.molpharmaceut.0c00608
Kirtipal, Nikhil, Shiv Bharadwaj, and Sang Gu Kang. "From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses." Infection, Genetics and Evolution 2020; 85:104502. https://doi.org/10.1016/j.meegid.2020.104502
Mousavizadeh, Leila, and Sorayya Ghasemi. "Genotype and phenotype of COVID-19: Their roles in pathogenesis." Journal of Microbiology, Immunology and Infection 2021; 54(2):159-163. https://doi.org/10.1016/j.jmii.2020.03.022
Xiao, Fei, Meiwen Tang, Xiaobin Zheng, Ye Liu, Xiaofeng Li, and Hong Shan. "Evidence for gastrointestinal infection of SARS-CoV-2." Gastroenterology 2020; 158(6):1831-1833. https://doi.org/10.1053/j.gastro.2020.02.055
MC, Raviglione. "Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J." Tuberculosis. Harrison's principles of internal medicine McGraw-Hill Education, 20th ed. New York, NY (2018).
Pathangey, Girish, Priyal P. Fadadu, Alexandra R. Hospodar, and Amr E. Abbas. "Angiotensin-converting enzyme 2 and COVID-19: patients, comorbidities, and therapies." American Journal of Physiology-Lung Cellular and Molecular Physiology 2021; 320(3):L301-L330.
Tosepu, Ramadhan, Joko Gunawan, Devi Savitri Effendy, Hariati Lestari, Hartati Bahar, and Pitrah Asfian. "Correlation between weather and Covid-19 pandemic in Jakarta, Indonesia." Science of the total environment 2020; 725:138436. https://doi.org/10.1016/j.scitotenv.2020.138436
Pagaya, Nofensi, Michael Mantiri, and Sofia E. Pangemanan. "Efektivitas Kinerja Satuan Tugas Penanganan Coronavirus Disease19 (Covid-19) Di Kabupaten Halmahera Utara." GOVERNANCE 2021; 1(2).
Wang, Dawei, Bo Hu, Chang Hu, Fangfang Zhu, Xing Liu, Jing Zhang, Binbin Wang et al. "Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China." Jama 2020; 323(11):1061-1069. https://doi.org/10.1001/jama.2020.1585
Gagliardi, Ida, Gemma Patella, Ashour Michael, Raffaele Serra, Michele Provenzano, and Michele Andreucci. "COVID-19 and the kidney: from epidemiology to clinical practice." Journal of Clinical Medicine 2020; 9(8):2506. https://doi.org/10.3390/jcm9082506
Gazzaz, Zohair Jamil. "Diabetes and COVID-19." Open Life Sciences 2021; 16(1):297-302. https://doi.org/10.1515/biol-2021-0034
Taneja, Sunil, Rohit Mehtani, and Yogesh Kumar Chawla. "Gastrointestinal and Liver Manifestations of COVID-19." Annals of the National Academy of Medical Sciences (India) 2020; 56(2):091-098. https://doi.org/10.1055/s-0040-1713837
Zhu, Jieyun, Zhimei Zhong, Pan Ji, Hongyuan Li, Bocheng Li, Jielong Pang, Jianfeng Zhang, and Chunling Zhao. "Clinicopathological characteristics of 8697 patients with COVID-19 in China: a meta-analysis." Family medicine and community health 2020; 8(2).
Guan, Wei-jie, Wen-hua Liang, Yi Zhao, Heng-rui Liang, Zi-sheng Chen, Yi-min Li, Xiao-qing Liu et al. "Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis." European Respiratory Journal 2020; 55(5).
Valderas, Jose M., Barbara Starfield, Bonnie Sibbald, Chris Salisbury, and Martin Roland. "Defining comorbidity: implications for understanding health and health services." The Annals of Family Medicine 2009; 7(4):357-363. https://doi.org/10.1370/afm.983
Li, Xuemei, Tao Li, and Huihui Wang. "Treatment and prognosis of COVID 19: Current scenario and prospects." Experimental and therapeutic medicine 2021; 21(1):1-1.
Surendra, Henry, Iqbal RF Elyazar, Bimandra A. Djaafara, Lenny L. Ekawati, Kartika Saraswati, Verry Adrian, Dwi Oktavia et al. "Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study." The Lancet Regional Health-Western Pacific 2021; 9:100108. https://doi.org/10.1016/j.lanwpc.2021.100108
Gupta, Nitesh, Pranav Ish, Rohit Kumar, Nishanth Dev, Siddharth Raj Yadav, Nipun Malhotra, Sumita Agrawal, Rajni Gaind, Harish Sachdeva, and Safdarjung Hospital COVID 2019 working group. "Evaluation of the clinical profile, laboratory parameters and outcome of two hundred COVID-19 patients from a tertiary centre in India." Monaldi archives for chest disease 2020; 90(4).
Marik, Paul Ellis, Sarah E. DePerrior, Qamar Ahmad, and Sunita Dodani. "Gender‐based disparities in COVID-19 patient outcomes." Journal of Investigative Medicine 2021; 69(4):814-818..
Young, Morag J., Colin D. Clyne, and Karen E. Chapman. "Endocrine aspects of ACE2 regulation: RAAS, steroid hormones and SARS-CoV-2." Journal of Endocrinology 2020; 247(2):R45-R62.
Garg, Shikha, Lindsay Kim, Michael Whitaker, Alissa O'Halloran, Charisse Cummings, Rachel Holstein, Mila Prill et al. "Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019-COVID-NET, 14 States, March 1-30, 2020." Morbidity and mortality weekly report 2020; 69(15):458. https://doi.org/10.15585/mmwr.mm6915e3
O'Hare, A. M., K. Berry, V. S. Fan, K. Crothers, M. C. Eastment, J. A. Dominitz, J. A. Shah, P. Green, E. Locke, and G. N. Ioannou. "Age differences in the association of comorbid burden with adverse outcomes in SARS-CoV-2." BMC geriatrics 2021; 21(1):1-10. https://doi.org/10.1186/s12877-021-02340-5
Song, Woo-Jung, Christopher KM Hui, James H. Hull, Surinder S. Birring, Lorcan McGarvey, Stuart B. Mazzone, and Kian Fan Chung. "Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses." The Lancet Respiratory Medicine 2021; 9(5):533-544. https://doi.org/10.1016/S2213-2600(21)00125-9
Patel, Vaibhav B., Nicola Clarke, Zuocheng Wang, Dong Fan, Nirmal Parajuli, Ratnadeep Basu, Brendan Putko, Zamaneh Kassiri, Anthony J. Turner, and Gavin Y. Oudit. "Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS." Journal of molecular and cellular cardiology 2014; 66:167-176. https://doi.org/10.1016/j.yjmcc.2013.11.017
Su, Liang, Xiang Ma, Huafeng Yu, Zhaohua Zhang, Pengfei Bian, Yuling Han, Jing Sun et al. "The different clinical characteristics of corona virus disease cases between children and their families in China-the character of children with COVID-19." Emerging microbes & infections 2020; 9(1):707-713. https://doi.org/10.1080/22221751.2020.1744483
Chen, Ganxiao, Xun Li, Zuojiong Gong, Hao Xia, Yao Wang, Xuefen Wang, Yan Huang, Hector Barajas-Martinez, and Dan Hu. "Hypertension as a sequela in patients of SARS-CoV-2 infection." PLoS One 2021; 16(4):e0250815.
Liu, Shuang, Yuxiang Zhi, and Sun Ying. "COVID-19 and asthma: reflection during the pandemic." Clinical reviews in allergy & immunology 2020; 59(1):78-88. https://doi.org/10.1007/s12016-020-08797-3
Published
Abstract Display: 549
PDF Downloads: 563
PDF Downloads: 38 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

.