Review: Hydrotropy as Prominent Approach for Enhancement of Aqueous Solubility of Drugs
Abstract
Solubility is crucial element to achieve the desired drug absorption in the total pharmacological response. Low water solubility can considerably limit the medication efficacy, and to improve aqueous solubility, a variety of approaches are employed. The capacity which increases water solubility for particular drug can thus be a useful tool for enhancing efficiency and/or decreasing negative effects. This is true for parental administered, topically applied and orally consumed solutions. It is a difficult work for researchers and pharmaceutical scientist to use solubility features in bioavailability, pharmacological effect and solubility enhancement of diverse weakly soluble substance. Hydrotropy is one of the strategies for increasing solubility. The purpose of this paper is to examine the hydrotropy Solubilization technique and to highlight the mechanism and different prospective of this method.
Keywords: Hydrotropy, mechanism, formation of hydrotropes, Solubility
Keywords:
Hydrotropy, mechanism, formation of hydrotropes, SolubilityDOI
https://doi.org/10.22270/jddt.v12i4.5461References
Tuitou E,Godin B, Weiss C. Enhanced delivery into and across the skin by ethosomal carriers. Drug Dev Res 2000; 50:406-45. https://doi.org/10.1002/1098-2299(200007/08)50:3/4<406::AID-DDR23>3.0.CO;2-M
Banker GS, Rhodes CT. Modern Pharmaceutics: Basic Principles and Systems. 4th ed. New York: Marcel Dekker Inc.; 2002. p. 200
Jain S, Umamaheshwari RB, Bhadra D, Jain NK. Ethosomes: A novel vesicular carrier for enhances transdermal delivery of an Anti HIV agent. Indian J Pharm Sci 2004; 66:72-81.
Jain S, Umamaheshwari RB, Bhadra D, Jain NK. Ethosomes: A novel vesicular carrier for enhances transdermal delivery of an Anti HIV agent. Indian J Pharm Sci 2004; 66:72-81. delivery. Pharm Rev 2004; 1:41-60.
Junginger HE, Hofland HE, Bouwrtra JA. Development of a topical anti-inflammatory gel from vitex negundo extract and evaluating it. Pharm Ztg 1991; 136:9-24.
Divya L, Keerthana LP. Enhancement of solubility of raloxifene HCl by formulating immediate and controlled release solid dispersion. Asian J Pharm Technol 2015; 5:238-48. https://doi.org/10.5958/2231-5713.2015.00034.3
Kaplun-Frischoff Y, Touitou E. Testosterone skin permeation enhancement by menthol through formation of eutectic with drug and interaction with skin lipids. J Pharm Sci 1997; 86:1394-9. https://doi.org/10.1021/js9701465
Lodzki M, Godin B, Rakou L, Mechoulam R, Gallily R, Touitou E, et al. Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model. J Control Release 2003; 93:377-87. https://doi.org/10.1016/j.jconrel.2003.09.001
Ranade VV. Drug Delivery Systems. Boca Raton, Florida: LLC Publishing Group, Taylor and Francis; 2002. p. 199-205.
Jain NK. Advances in Controlled and Novel Drug Delivery. New Delhi: CBS Publication; 2001. p. 428-51.
Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 2000; 50:47-60. https://doi.org/10.1016/S0939-6411(00)00076-X
Sonawale P, Patil A, Kamble A, Bhutkar M. Solubility enhancement of lipophilic drugs-solid self micro emulsifying drug delivery system. Asian J Pharm Technol 2016; 6:155-8. https://doi.org/10.5958/2231-5713.2016.00022.2
Neuberg C. Hydrotropy. Biochemistry 1916; 76:107-109.
Rajawardhan Reddy M, Prasanna Kumar D. A Review on Hydrotropy. Journal of Pharmaceutical Research 2013; 2(4):5-6.
Friberg E, Brancewicz C. O/W Microemulsions and Hydrotropes: The Coupling Action of a Hydrotrope, Langmuir 1994; 10:2945-2949. https://doi.org/10.1021/la00021a016
Hatzopoulos M, Eastoe J, Peter J, Rogers S, Heenan R, Dyer are Hydrotropes Distinct from Surfactants, Langmuir. 2011; 27:12346-12353. https://doi.org/10.1021/la2025846
Vemula V.R, Lagishetty V, Lingala S. Solubility Enhancement Techniques.International Journal of Pharmaceutical Sciences Review and Research. 2010; 5(1):41-51. https://doi.org/10.1002/chin.201141266
Asmat Majeed, Syed Naiem Raza, Nisar Ahmad Khan. Hydrotropy: Novel Solubility Enhancement Technique: A Review. International Journal of Scientific progress and research 2019; 10(3):10251036.
Vividha Dhapte, Piyush Mehta. Advances in Hydrotropic Solutions: an Updated Review. St.PetersburgPolytechnical University. Journal Physics and Mathematics 2015; 1:424-435. https://doi.org/10.1016/j.spjpm.2015.12.006
Dhapte V and Mehta P: Advances in hydrotropic solutions:An updated review. St. Petersburg Polytechnical University Journal: Physics & Mathematics 2015; 1:424-435. https://doi.org/10.1016/j.spjpm.2015.12.006
Verma G, Aswal VK, Fritz-Popovski G, Shah CP, Kumar M and Hassan PA: Dilution induced thickening in hydrotrope-rich rod-like micelles. Journal of Colloid and Interface Science 2011; 359:163-170. https://doi.org/10.1016/j.jcis.2011.03.061
Neumann MG, Schmitt CC, Prieto KR and Goi BE: The photophysical determination of the minimum hydrotrope concentration of aromatic hydrotropes. Journal of Colloid and Interface Science 2007; 315:810-813. https://doi.org/10.1016/j.jcis.2007.07.020
De Paula WX, Denadai AML, Santoro MM, Braga ANG, Santos RAS and Sinisterra RD: Supramolecular interactions between losartan and hydroxyl propyl-β-CD: ESI mass- spectrometry, NMR techniques, Phase solubility, Isothermal titration calorimetry and antihypertensive studies. Inter Jour of Pharmaceutics 2011; 404:116-123. https://doi.org/10.1016/j.ijpharm.2010.11.008
Szabo K, Wang P, Peles-Lemli B, Fang Y, Kollar L and Kunsagi-Mate S: Structure of aggregate of hydrotropic p toluene sulfonate and hydroxyacetophenoneisomers.Colloids and Surfaces A: Physicochemical and Engineering Aspects 2013; 422:143-147. https://doi.org/10.1016/j.colsurfa.2013.01.034
Gaikar VG and Pathak PPV: Selective solubilization of isomers in hydrotrope solution o-p-chlorobenzoic acids and o-p-nitro anilines. Separation Science and Technology 1999; 34:439-459. https://doi.org/10.1081/SS-100100660
Shimizu S and Matubayasi N: Hydrotrophy: monomermicelle equilibrium and minimum hydrotrope concentration. J of Phyical Chemistry B 2014; 118:10515-10524 https://doi.org/10.1021/jp505869m
Cui Y: Hydrotropic solubilization by urea derivatives:A Molecular dynamics simulation study. Journal of Pharmaceutics 2013; 1-15. https://doi.org/10.1155/2013/791370
Khanam A, Sheikh M, Khan I and Khabir-ud-din: Aggregational behavior of alkane dinyl-α-w-bis (tetradecyl dimethyl ammonium) dibromide series with ionic and nonionic hydrotropes at different temperatures. of Industrial and Engineering Chemistry 2014; 20: 3453-3460. https://doi.org/10.1016/j.jiec.2013.12.034
Rub MA, Azum N, Kuman D, Khan F and AisiriAM:Clouding phenomenon of amphiphilic drug Promazine hydrochloride solutions: Influence of pharmaceutical excipients. Jour of Industrial and Engineering Chemistry 2015; 21:1119-1126. https://doi.org/10.1016/j.jiec.2014.05.023
Lee SC, Huh KM, Lee J, Cho YE, Galinsky RE and Park K: Hydrotrophy polymeric micelles for enhanced paclitaxel solubility: In-vitro and in-vivo characterization.Biomacromolecules 2007; 8:202-208. https://doi.org/10.1021/bm060307b
Rub MA, Asiri AM, Azum N and Kabir-ud-Din: Investigation of micellar and phase separation phenomenon of phenothiazine drug promazine hydrochloride with anionic hydrotropes. Journal of Industrial and Engineering Chemistry 2014; 20:2023-2034. https://doi.org/10.1016/j.jiec.2013.09.027
Niazi, S.K. Handbook of Pharmaceutical Manufacturing Formulations: Liquid Products. America: CRC Press 2004. https://doi.org/10.1201/9781420048452
Maheshwari R.K, Indurkhya.A. Formulation and Evaluation of Aceclofenac Injection Made by Mixed Hydrotropic Solubilization Technique. Iranian Journal of Pharmaceutical Research 2010; 9(3): 233-242.
Kwon.G.S, Okano.T. Polymeric micelles as new drug carriers. Advances of Drug Delivery Revised 1996; 21:107-116. https://doi.org/10.1016/S0169-409X(96)00401-2
Rosler.A, Vandermeulen G.M, KlokHA. Advanced drug delivery devices via selfassembly of amphiphilic block copolymers, Advanced Drug Delivery Revised 2001; 53:95-108. https://doi.org/10.1016/S0169-409X(01)00222-8
Trubetskoy V.S. Polymeric micelles as carriers of diagnostic agents. Advanced Drug Delivery Revised 1999; 37:81-88. https://doi.org/10.1016/S0169-409X(98)00100-8
Kataoka.K, Harada.A, Nagasaki.Y. Block copolymer micelles for drug delivery:design, characterization and biological significance. Advanced Drug Delivery Revised 2001; 47:113131. https://doi.org/10.1016/S0169-409X(00)00124-1
Yokoyama.M, Okano.T, Sakurai.Y, Suwa.S, KataokaK.Introduction of cisplatin into polymeric micelle. Journal of Controlled Release 1996; 39:351-356. https://doi.org/10.1016/0168-3659(95)00165-4
Nishiyama.N, Kato.Y, Sugiyama.Y, KataokaK. Cisplatin loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system. Pharmaceutical Research 2001; 18:1035-1041. https://doi.org/10.1023/A:1010908916184
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